Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RB1CC1, IRF3 (from a repository: Mon Jul 29 07:59:58 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)138
The number (and %) of the onco-proteins36 (26.09 %)
The number (and %) of the tumor suppressors36 (26.09 %)
Total number of binary PPIs (saturation %)609 (6.44 %)
The number (and %) of affected PPIs140 (22.99 %)
The number of possible different fusions37
PPI diameter4
PPI radius2
The average degree of PPI7.855
Assortativity coefficient-0.3601
The network average Clustering coefficient0.348
The number (and %) of a zero Clustering coefficients32 (23.19 %)
The number (and %) of a zero Betweenness Centrality29 (21.01 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RB1CC1,IRF3 All fusions
Proteins found in more fusions RBMX (see 3 fusions); TRAF6 (see 1 fusions); SMAD4 (see 3 fusions); CTNNB1/SMAD2 (see 1 fusions); FOXO1 (see 3 fusions); HSP90AA1 (see 6 fusions); SMAD2 (see 2 fusions); TICAM1 (see 1 fusions); GABARAP (see 2 fusions); HUWE1 (see 4 fusions); CUL1 (see 3 fusions); SMARCB1 (see 12 fusions); PINK1 (see 3 fusions); MAPK9 (see 3 fusions); PTK2B (see 1 fusions); VHL (see 1 fusions); CREBBP (see 6 fusions); SYN1 (see 1 fusions); EWSR1 (see 1 fusions); RNF111 (see 1 fusions); DCTN1 (see 2 fusions); PRDX1 (see 1 fusions); FASN (see 1 fusions); ULK1 (see 2 fusions); MAVS (see 1 fusions); SKI (see 1 fusions); IRF7 (see 1 fusions); POLR2A (see 2 fusions); PTK2 (see 3 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); UBC (see 7 fusions); RPA1 (see 1 fusions); ERRFI1 (see 1 fusions); HSBP1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RB1CC1parental protein730.0347673.422Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
2 IRF3parental protein670.0775396.075IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
3 ADGRL2oncoprotein1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Latrophilin (PF02354, IPR003334): Latrophilin Cytoplasmic C-terminal region
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
zf-C2HCIx2C (PF10782, IPR019718): Zinc-finger
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
4 AKT1oncoprotein270.151734.299PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ASMTLinteractor200Maf (PF02545, IPR003697): Maf-like protein
Methyltransf_2 (PF00891, IPR001077): O-methyltransferase
Dimerisation2 (PF16864, IPR031725): Dimerisation domain
6 ATG101interactor50.7004.418ATG101 (PF07855, IPR012445): Autophagy-related protein 101
7 ATG13oncoprotein90.52824.084ATG13 (PF10033, IPR018731): Autophagy-related protein 13
8 ATG16L1interactor90.393104.979ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
9 ATG5interactor40.66712.913APG5 (PF04106, IPR007239): Autophagy protein Apg5
10 BAP1suppressor30.33320.889Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
11 BCAS3oncoprotein31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
BCAS3 (PF12490, IPR022175): Breast carcinoma amplified sequence 3
12 BLIDsuppressor100NA
13 CALCOCO2interactor150.286175.444bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
14 CCDC8interactor150.308189.639Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
15 CDK19interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
16 CREBBPsuppressor190.314178.512Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
17 CTNNB1oncoprotein150.238257.224Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
18 CUL1suppressor170.167287.434Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19 DBNLinteractor206.886RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
20 DCTN1protein found in more fusions40.6674.656Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
21 DDX58suppressor70.6008.459DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
AAA_22 (PF13401, IPR003593): AAA domain
Syntaxin_2 (PF14523): Syntaxin-like protein
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
22 DEAF1interactor30.6670.400Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
23 DLG3interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 DYRK2interactor40.5008.135Pkinase (PF00069, IPR000719): Protein kinase domain
25 EP300oncoprotein240.289264.320Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
26 EPSTI1interactor3015.401TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
27 ERCC6Linteractor208.809SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
TPR_11 (PF13414, IPR011990): TPR repeat
28 ERRFI1suppressor308.809GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
29 ESYT2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
30 EWSR1oncoprotein190.235260.691RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
31 EXOC1interactor100FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
Sec3-PIP2_bind (PF15277, IPR028258): Exocyst complex component SEC3 N-terminal PIP2 binding PH
32 FASNprotein found in more fusions70.46715.091Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
33 FOXO1suppressor90.50043.160K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
34 GABARAPsuppressor110.44475.699Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
35 GABARAPL1interactor80.42958.637Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
36 GLCEinteractor2052.754C5-epim_C (PF06662, IPR010598): D-glucuronyl C5-epimerase C-terminus
EspG (PF06872, IPR009669): EspG protein
37 GREB1interactor2010.840GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
38 HBP1suppressor60.267112.271AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
39 HDAC3suppressor140.269167.506Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
40 HERC5interactor50.33310.041Peptidase_S51 (PF03575, IPR005320): Peptidase family S51
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
41 HK2interactor30.6672.011Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
42 HSBP1protein found in more fusions200HSBP1 (PF06825, IPR009643): Heat shock factor binding protein 1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
43 HSP90AA1oncoprotein220.138495.552HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
44 HUWE1oncoprotein130.303151.108BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
45 IKBKEinteractor150.418115.953IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
46 IL13RA2interactor207.181fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
47 IL24suppressor30.33318.022IL22 (PF14565, IPR020453): Interleukin 22 IL-10-related T-cell-derived-inducible factor
48 IPO5interactor70.238117.079HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
49 IRF5suppressor80.38112.009IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
50 IRF7protein found in more fusions150.308131.584IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
51 ITIH5interactor100ITI_HC_C (PF06668, IPR010600): Inter-alpha-trypsin inhibitor heavy chain C-terminus
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
52 KIToncoprotein21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
53 LYPD3oncoprotein3056.566DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
54 MADDsuppressor208.809DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus
uDENN (PF03456, IPR005113, SM00800): uDENN domain
55 MAFBoncoprotein40.6670.400bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
56 MAP1LC3Cinteractor80.53623.273Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
57 MAP3K5oncoprotein120.255143.819Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
58 MAPK8oncoprotein90.57116.078DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
59 MAPK9suppressor70.53310.940Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
60 MAVSprotein found in more fusions140.46240.522Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
61 MOB4interactor30.33345.232Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
62 MRC2interactor207.181Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
63 NANOGinteractor70.133103.260Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
64 PEX19interactor50.30072.796Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
65 PIAS4interactor90.33363.294CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
66 PIN1suppressor110.36474.371Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
67 PINK1protein found in more fusions70.40061.890Pkinase (PF00069, IPR000719): Protein kinase domain
68 POLR2Aprotein found in more fusions130.33368.593RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
69 PPIP5K1interactor100His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
70 PRDX1oncoprotein80.19073.985AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
71 PRKAA2suppressor60.40034.525Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
72 PRKAB2interactor70.6005.245AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
73 PSMA5oncoprotein60.33323.361Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
74 PSMC3IPinteractor100Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
75 PTK2protein found in more fusions40.6675.785FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
76 PTK2Bprotein found in more fusions50.16735.502FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
77 RB1suppressor90.36153.447RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
78 RBL1suppressor40.5006.626RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
79 RBL2suppressor50.30027.594CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
80 RBMXsuppressor60.6004.348RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
81 RFWD2suppressor50.16755.532Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
82 RNF111suppressor80.33345.896zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
83 RNF20interactor41.0000Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
84 RPA1suppressor140.346162.551Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
85 RPA2oncoprotein120.348130.927RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
86 SAFBsuppressor60.53331.216RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
87 SAFB2suppressor50.60019.870LicD (PF04991, IPR007074): LicD family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
88 SALL2suppressor30.33311.482CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
89 SESN2interactor40.50018.437PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
90 SGO1interactor100DUF778 (PF05608, IPR008496): Protein of unknown function (DUF778)
Menin (PF05053, IPR007747): Menin
Shugoshin_C (PF07557, IPR011515): Shugoshin C terminus
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
91 SGTAinteractor50.50011.771TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
92 SGTBinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
93 SKIoncoprotein110.333105.628c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
94 SKILsuppressor80.47658.050c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
95 SLMAPinteractor3073.286Fez1 (PF06818): Fez1
FHA (PF00498, IPR000253, SM00240): FHA domain
Spectrin (PF00435, IPR002017): Spectrin repeat
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
96 SMAD2suppressor160.381133.411MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
97 SMAD4suppressor220.210472.190MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
98 SMARCB1suppressor70.33346.072SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
99 SMC1Aoncoprotein90.39348.460SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
100 SMC2interactor50.60016.479SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
101 SMCR8interactor100Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
102 SOCS1suppressor50.20053.789SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
103 SORT1interactor21.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
104 SYN1protein found in more fusions200Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
105 SYNGR3interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
106 TACC1oncoprotein21.0000TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
107 TANKsuppressor90.7142.892DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
108 TBK1interactor240.253792.557DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
109 TBKBP1interactor50.83316.190Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
TBD (PF12845, IPR024581): TBD domain
110 TCEAL4interactor21.0000BEX (PF04538, IPR021156): Brain expressed X-linked like family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
111 TEX36interactor100HDNR (PF15115, IPR029369): Domain of unknown function with conserved HDNR motif
112 THRSPoncoprotein40.33318.022Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
113 TICAM1protein found in more fusions100.58318.684Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
114 TLR2interactor40.33316.606LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
115 TMEM173interactor60.9000.580TMEM173 (PF15009, IPR029158): Transmembrane protein 173
116 TOMM70interactor70.57118.581PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
117 TP53suppressor300.143854.773DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
118 TRAF2interactor210.326523.274MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
119 TRAF3oncoprotein120.52727.093ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
120 TRAF3IP2interactor90.6439.487SEFIR (PF08357, IPR013568): SEFIR domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
121 TRAF6protein found in more fusions170.283132.868SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
122 TRIM21interactor120.200168.258DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
123 TRIM26interactor50.5004.480Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
124 TROinteractor203.259MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
125 TUBB8interactor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
126 UBCprotein found in more fusions300.128975.657ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
127 ULK1protein found in more fusions140.321413.443Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
128 ULK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
129 UMPSinteractor21.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
130 VAPBinteractor40.66713.524ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
131 VHLsuppressor140.218232.736Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
132 VPS45interactor100Sec1 (PF00995, IPR001619): Sec1 family
133 WHSC1L1suppressor207.181PHD (PF00628, IPR019787, SM00249): PHD-finger
Presenilin (PF01080, IPR001108): Presenilin
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
134 WIF1suppressor100EGF_2 (PF07974, IPR013111): EGF-like domain
WIF (PF02019, IPR003306, SM00469): WIF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
135 WRNIP1interactor70.40014.724AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
136 XIAPinteractor90.53651.484BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
137 XPO1interactor240.105766.761CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
138 YLPM1interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

B a c k    t o    T o p ⇑