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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)92
The number (and %) of the onco-proteins24 (26.09 %)
The number (and %) of the tumor suppressors20 (21.74 %)
Total number of binary PPIs (saturation %)436 (10.42 %)
The number (and %) of affected PPIs92 (21.10 %)
The number of possible different fusions20
PPI diameter4
PPI radius2
The average degree of PPI8.391
Assortativity coefficient-0.2521
The network average Clustering coefficient0.438
The number (and %) of a zero Clustering coefficients10 (10.87 %)
The number (and %) of a zero Betweenness Centrality14 (15.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: POLD3,IRF3 All fusions
Proteins found in more fusions REV1 (see 1 fusions); CREBBP (see 6 fusions); TRAF6 (see 1 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); SMAD4 (see 2 fusions); PRDX1 (see 1 fusions); FOXO1 (see 1 fusions); HSP90AA1 (see 3 fusions); ULK1 (see 2 fusions); TICAM1 (see 1 fusions); POLR2A (see 2 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); TRIM26 (see 1 fusions); PCNA (see 1 fusions); MAPK9 (see 3 fusions); CHD4 (see 6 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 POLD3parental protein250.173812.808CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
2 IRF3parental protein670.0774154.324IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
3 ADGRL2oncoprotein1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Latrophilin (PF02354, IPR003334): Latrophilin Cytoplasmic C-terminal region
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
zf-C2HCIx2C (PF10782, IPR019718): Zinc-finger
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
4 AHSA1interactor50.40021.051Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5 AKT1oncoprotein200.211311.351PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6 APPprotein found in more fusions110.200128.277APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ASMTLinteractor305.159Maf (PF02545, IPR003697): Maf-like protein
Methyltransf_2 (PF00891, IPR001077): O-methyltransferase
Dimerisation2 (PF16864, IPR031725): Dimerisation domain
8 BCAS3oncoprotein40.6675.728WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
BCAS3 (PF12490, IPR022175): Breast carcinoma amplified sequence 3
9 CHD4oncoprotein90.7865.068CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Coilin_N (PF15862, IPR031722): Coilin N-terminus
10 CREBBPsuppressor170.400121.326Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
11 CUL1suppressor130.197157.747Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 DCP2interactor3017.796DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
13 DCTN1interactor50.33316.523Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
14 DDX58suppressor60.7003.938DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
AAA_22 (PF13401, IPR003593): AAA domain
Syntaxin_2 (PF14523): Syntaxin-like protein
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
15 DEAF1interactor30.6670.400Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
16 DNMT1suppressor120.52739.921BAH (PF01426, IPR001025, SM00439): BAH domain
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
17 EP300oncoprotein230.303290.903Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
18 ESYT2interactor2014.751C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
19 EWSR1oncoprotein150.297146.014RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
20 FAF2interactor7079.276DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
21 FASNinteractor60.60018.187Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
22 FOXO1suppressor80.6673.401K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
23 HDAC1suppressor260.213442.684FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
24 HDAC3suppressor130.333123.995Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
25 HERC5interactor40.3332.853Peptidase_S51 (PF03575, IPR005320): Peptidase family S51
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
26 HK2interactor30.6671.499Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
27 HSP90AA1oncoprotein170.200254.532HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
28 IKBKEinteractor120.50923.007IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
29 IPO5interactor40.33317.150HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
30 IRF5suppressor90.39336.675IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
31 IRF7interactor150.30890.562IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
32 KIToncoprotein21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
33 MAD2L2interactor31.0000HORMA (PF02301, IPR003511): HORMA domain
34 MAFBoncoprotein40.6670.400bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
35 MAPK8oncoprotein100.50029.959DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
36 MAPK9suppressor70.53313.226Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
37 MAVSinteractor130.48521.210Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
38 MBD3L2interactor51.0000MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
39 MCM3interactor70.14342.127MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
40 MTA1oncoprotein90.69417.436BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
41 NR2C1interactor70.8104.735zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
42 PCNAoncoprotein180.265261.427PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
43 PEX19interactor50.30025.216Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
44 PIAS4interactor80.46461.607CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
45 PIN1suppressor100.37846.267Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
46 POLA1interactor60.33317.088DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-DNA_Pol (PF08996, IPR015088): DNA Polymerase alpha zinc finger
DNA_pol_alpha_N (PF12254, IPR024647): DNA polymerase alpha subunit p180 N terminal
47 POLD1interactor100.37888.011DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
48 POLD2interactor80.50044.882DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
49 POLD4interactor51.0000DNA_pol_delta_4 (PF04081, IPR007218): DNA polymerase delta, subunit 4
50 POLR2Aprotein found in more fusions110.35651.526RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
51 PPIP5K1interactor100His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
52 PRDX1oncoprotein31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
53 PSMA5oncoprotein50.30013.279Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
54 RB1suppressor100.44479.780RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
55 RBBP4oncoprotein130.46265.079eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
56 RBL1suppressor50.5006.853RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
57 RBL2suppressor60.33338.096CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
58 REV1protein found in more fusions70.40061.265IMS (PF00817, IPR001126): impB/mucB/samB family
Cdd1 (PF11731, IPR021725): Pathogenicity locus
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
REV1_C (PF16727, IPR031991): DNA repair protein REV1 C-terminal domain
59 SALL2suppressor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
60 SGTAinteractor50.50015.311TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
61 SIRT6suppressor80.28664.531SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
62 SLMAPinteractor100Fez1 (PF06818): Fez1
FHA (PF00498, IPR000253, SM00240): FHA domain
Spectrin (PF00435, IPR002017): Spectrin repeat
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
63 SMAD2suppressor130.50044.190MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
64 SMAD4suppressor150.39652.206MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
65 SMC1Aoncoprotein70.33353.532SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
66 SMC2interactor30.66716.997SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
67 SOCS1suppressor30.33311.073SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
68 SORT1interactor40.16789.069Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
69 SPRTNinteractor51.0000GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
70 SYNGR3interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
71 TANKsuppressor100.61113.572DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
72 TBK1interactor200.322139.079DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
73 TEX36interactor100HDNR (PF15115, IPR029369): Domain of unknown function with conserved HDNR motif
74 TICAM1protein found in more fusions100.58315.764Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
75 TLR2interactor31.0000LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
76 TMEM173interactor60.9000.500TMEM173 (PF15009, IPR029158): Transmembrane protein 173
77 TOMM70interactor60.6675.057PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
78 TP53suppressor220.243291.455DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
79 TRAF2interactor160.40059.417MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
80 TRAF3oncoprotein110.62211.425ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
81 TRAF3IP2interactor80.7143.377SEFIR (PF08357, IPR013568): SEFIR domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
82 TRAF6protein found in more fusions140.32155.675SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
83 TRIM21interactor80.23885.401DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
84 TRIM26protein found in more fusions41.0000Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
85 TROinteractor2014.751MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
86 TSEN2interactor40.33319.676tRNA_int_endo (PF01974, IPR006677): tRNA intron endonuclease, catalytic C-terminal domain
tRNA_int_endo_N (PF02778, IPR006678): tRNA intron endonuclease, N-terminal domain
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
87 TUBB8interactor30.33342.054Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
88 ULK1protein found in more fusions40.6670.939Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
89 USP8interactor40.3339.749DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
90 WRNIP1interactor80.33356.764AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
91 XIAPinteractor80.57112.845BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
92 XPO1interactor170.162333.216CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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