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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins INCENP, CSMD2 (from a repository: Mon Aug 13 23:21:16 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins3 (15.00 %)
The number (and %) of the tumor suppressors2 (10.00 %)
Total number of binary PPIs (saturation %)60 (31.58 %)
The number (and %) of affected PPIs18 (30.00 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI5.200
Assortativity coefficient-0.5260
The network average Clustering coefficient0.659
The number (and %) of a zero Clustering coefficients2 (10.00 %)
The number (and %) of a zero Betweenness Centrality8 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CSMD2,INCENP All fusions
Proteins found in more fusions EWSR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CSMD2interactor000CUB (PF00431, IPR000859, SM00042): CUB domain
Hep_core_N (PF08290, IPR013195): Hepatitis core protein, putative zinc finger
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
2 INCENPparental protein180.222157.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
3 AURKAoncoprotein50.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 AURKBinteractor130.40929.000Pkinase (PF00069, IPR000719): Protein kinase domain
5 AURKCinteractor40.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
6 BIRC5interactor90.5368.333BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
7 CBX5suppressor70.6674.500Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
8 CDCA8interactor100.52812.500Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
9 EVI5interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
10 EWSR1oncoprotein40.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 FLOT1interactor31.0000CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
12 H2AFZinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
13 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
14 HIST1H2BGoncoprotein50.9000.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HIST1H3Ainteractor100.36120.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HIST2H3Cinteractor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18 PHF8interactor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
19 SGO1interactor50.9000.500DUF778 (PF05608, IPR008496): Protein of unknown function (DUF778)
Menin (PF05053, IPR007747): Menin
Shugoshin_C (PF07557, IPR011515): Shugoshin C terminus
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
20 SIRT7interactor40.5002.333DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family

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