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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IL10RA, WSB1 (from a repository: Sun Feb 11 14:20:23 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins7 (38.89 %)
The number (and %) of the tumor suppressors3 (16.67 %)
Total number of binary PPIs (saturation %)46 (30.07 %)
The number (and %) of affected PPIs16 (34.78 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI4.111
Assortativity coefficient-0.1336
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients7 (38.89 %)
The number (and %) of a zero Betweenness Centrality4 (22.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: IL10RA,WSB1 All fusions
Proteins found in more fusions DDB1 (see 2 fusions); JAK1 (see 1 fusions); CUL4A (see 4 fusions); GSK3B (see 1 fusions); HIPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IL10RAparental protein4068.000Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
2 WSB1parental protein120.227123.517PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
SOCS_box (PF07525, IPR001496): SOCS box
3 ARHGDIBinteractor100Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4 BTRConcoprotein70.06781.050WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CSF3Roncoprotein30.33323.950EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
6 CUL4Aprotein found in more fusions60.70017.805Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 CUL5suppressor70.66710.527Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
8 DCUN1D1interactor60.7335.956Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
9 DDB1protein found in more fusions60.70017.805CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
10 DIO2oncoprotein51.0000T4_deiodinase (PF00837, IPR000643): Iodothyronine deiodinase
11 GSK3Bsuppressor40.3337.480Pkinase (PF00069, IPR000719): Protein kinase domain
12 HIPK2suppressor305.480Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
13 IL10interactor200IL10 (PF00726, IPR020443, SM00188): Interleukin 10
14 IL10RBinteractor100DUF1201 (PF06716, IPR009591): Protein of unknown function (DUF1201)
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
15 JAK1oncoprotein309.950FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 TCEB1oncoprotein50.9000.500Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
17 TCEB2interactor50.9000.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
18 UBE2D3interactor305.480UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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