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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)122
The number (and %) of the onco-proteins39 (31.97 %)
The number (and %) of the tumor suppressors18 (14.75 %)
Total number of binary PPIs (saturation %)400 (5.42 %)
The number (and %) of affected PPIs120 (30.00 %)
The number of possible different fusions22
PPI diameter2
PPI radiusinf
The average degree of PPI5.934
Assortativity coefficient-0.4353
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients23 (18.85 %)
The number (and %) of a zero Betweenness Centrality56 (45.90 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions NFIX (see 3 fusions); TPM2 (see 1 fusions); SART3 (see 2 fusions); APP (see 4 fusions); TPM1 (see 2 fusions); KAT2B (see 1 fusions); NR2F2 (see 1 fusions); L3MBTL3 (see 1 fusions); GSK3B (see 1 fusions); KDM1A (see 2 fusions); HSPB1 (see 4 fusions); TPM2/TPM1 (see 1 fusions); KAT5 (see 3 fusions); FNBP1 (see 7 fusions); CUL1 (see 3 fusions); MBD2 (see 1 fusions); RUNX1T1 (see 1 fusions); RANGAP1 (see 2 fusions); CHD4 (see 6 fusions); MYC (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RBPJparental protein1200.03412304.448BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
2 DIRC3oncoprotein000YrzO (PF14142, IPR025417): YrzO-like protein
3 ADARinteractor50.8000.722dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
4 ADNPinteractor60.4675.619zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
PHD_Oberon (PF07227, IPR032881): PHD - plant homeodomain finger protein
E6 (PF00518, IPR001334): Early Protein (E6)
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
5 ALX4interactor200OAR (PF03826, IPR003654): OAR domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
6 APPprotein found in more fusions190.170117.322APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARID3Binteractor21.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Phycobilisome (PF00502, IPR012128): Phycobilisome protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
8 BCL6Bsuppressor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Lar_restr_allev (PF14354): Restriction alleviation protein Lar
9 CAMK4interactor21.0000DUF1103 (PF06513, IPR009484): Repeat of unknown function (DUF1103)
Pkinase (PF00069, IPR000719): Protein kinase domain
10 CAMSAP1interactor100CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
ARGLU (PF15346): Arginine and glutamate-rich 1
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
11 CDC27oncoprotein70.4675.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
12 CFDP1interactor21.0000BCNT (PF07572, IPR011421): Bucentaur or craniofacial development
DUF789 (PF05623, IPR008507): Protein of unknown function (DUF789)
YL1 (PF05764, IPR008895): YL1 nuclear protein
DUF4048 (PF13257, IPR025122): Domain of unknown function (DUF4048)
13 CGGBP1interactor31.0000AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95)
Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
14 CHAF1Binteractor21.0000Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
CAF-1_p60_C (PF15512, IPR029129): Chromatin assembly factor complex 1 subunit p60, C-terminal
15 CHD4oncoprotein130.51514.413CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Coilin_N (PF15862, IPR031722): Coilin N-terminus
16 CIR1interactor31.0000DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
IncA (PF04156, IPR007285): IncA protein
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
YebO (PF13974, IPR025594): YebO-like protein
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
17 CLPTM1interactor100CLPTM1 (PF05602, IPR008429): Cleft lip and palate transmembrane protein 1 (CLPTM1)
PQ-loop (PF04193, IPR006603): PQ loop repeat
18 CREMsuppressor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
19 CUL1suppressor100.36118.789Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20 CUX1suppressor40.8330.400Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
CUT (PF02376, IPR003350, SM01109): CUT domain
DegS (PF05384, IPR008595): Sensor protein DegS
DivIC (PF04977, IPR007060): Septum formation initiator
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Swi5 (PF07061, IPR010760): Swi5
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
ApoO (PF09769, IPR019166): Apolipoprotein O
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
21 DCAF16interactor100DCA16 (PF15349, IPR028216): DDB1- and CUL4-associated factor 16
22 DDX24interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DEKoncoprotein60.5334.133DEK_C (PF08766, IPR014876): DEK C terminal domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
SAP (PF02037, IPR003034, SM00513): SAP domain
Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
24 DLX5interactor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
25 ELAVL1oncoprotein270.160238.789RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 FBXO42interactor21.0000Kelch_2 (PF07646, IPR011498): Kelch motif
F-box-like (PF12937, IPR001810): F-box-like
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
27 FHL1suppressor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
28 FNBP1oncoprotein31.0000FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Laminin_II (PF06009, IPR010307): Laminin Domain II
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
29 FNBP1Linteractor100FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
DEDD_Tnp_IS110 (PF01548, IPR002525): Transposase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
GTP-bdg_M (PF16360, IPR032305): GTP-binding GTPase Middle Region
30 GADD45Asuppressor31.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
31 GATAD2Ainteractor50.8000.800DUF2299 (PF10061, IPR018747): Uncharacterized conserved protein (DUF2299)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
32 GSK3Bsuppressor90.5367.433Pkinase (PF00069, IPR000719): Protein kinase domain
33 GTF3C4interactor40.8330.400TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
34 GTF3C5interactor50.5002.833Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Tau95 (PF09734, IPR019136): RNA polymerase III transcription factor (TF)IIIC subunit
35 H2AFYinteractor70.38111.233DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
36 HDAC2suppressor230.264129.640Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37 HMG20Binteractor60.5333.867IncA (PF04156, IPR007285): IncA protein
NEMP (PF10225, IPR019358): NEMP family
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
38 HOXA10interactor40.6671.667Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
39 HOXB9interactor100Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
40 HOXC13oncoprotein100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
41 HOXD13oncoprotein21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
42 HSPB1oncoprotein70.5332.806HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
43 JMJD1Cinteractor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
RbpA (PF13397, IPR025182): RNA polymerase-binding protein
44 KAT2Ainteractor50.5002.167Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
45 KAT2Bprotein found in more fusions100.30620.319Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
46 KAT5suppressor70.6003.433MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
47 KDM1Aprotein found in more fusions130.36428.325Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
48 KDM2Ainteractor30.6670.500JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
DZR (PF12773, IPR025874): Double zinc ribbon
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
49 KDM5Asuppressor30.6670.333ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
FRG1 (PF06229, IPR010414): FRG1-like domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
50 KIF2Cinteractor60.5004.067Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
51 L3MBTL3protein found in more fusions50.5002.167CDC45 (PF02724, IPR003874): CDC45-like protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain
MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
Calci_bind_CcbP (PF11535, IPR020994): Calcium binding
Apelin (PF15360, IPR026155): APJ endogenous ligand
52 LCORinteractor100DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553)
53 MAML1interactor110.32725.000MamL-1 (PF09596, IPR019082): MamL-1 domain
Kri1 (PF05178, IPR018034): KRI1-like family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
54 MAML2oncoprotein31.0000Senescence_reg (PF04520, IPR007608): Senescence regulator
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
MamL-1 (PF09596, IPR019082): MamL-1 domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
55 MAML3interactor31.0000Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
MamL-1 (PF09596, IPR019082): MamL-1 domain
DUF2459 (PF09601, IPR011727): Protein of unknown function (DUF2459)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SprA-related (PF12118, IPR021973): SprA-related family
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM70 (PF14967, IPR028014): FAM70 protein
56 MAP7D3interactor100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
ARGLU (PF15346): Arginine and glutamate-rich 1
57 MBD1interactor31.0000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
58 MBD2oncoprotein80.5715.000API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
59 MECP2interactor40.5001.500K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
60 MED23interactor90.27822.352Med23 (PF11573, IPR021629): Mediator complex subunit 23
61 MED27interactor21.0000Med27 (PF11571, IPR021627): Mediator complex subunit 27
62 MYConcoprotein230.216134.871HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
63 MYH7interactor21.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
64 NACC1interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
65 NCOR2oncoprotein80.5718.750CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
66 NFATC1oncoprotein120.27340.436RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
67 NFIAinteractor50.6002.833CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
68 NFIConcoprotein31.0000CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
69 NFIXoncoprotein200CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
70 NKX2-5oncoprotein100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
71 NKX6-1interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TSP9 (PF11493, IPR021584): Thylakoid soluble phosphoprotein TSP9
DUF4357 (PF14267, IPR025579): Domain of unknown function (DUF4357)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
72 NOTCH1suppressor230.190153.052Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
73 NOTCH2suppressor60.4675.519Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
74 NOTCH3suppressor60.6672.167Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
75 NR2F2protein found in more fusions31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
76 OGTinteractor40.5002.333TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
77 PATZ1oncoprotein200AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
78 PBX1oncoprotein50.4004.400PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
79 PHF21Ainteractor50.8000.786AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
PHD (PF00628, IPR019787, SM00249): PHD-finger
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
80 PHF8interactor60.6004.500JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
81 PITX2interactor200OAR (PF03826, IPR003654): OAR domain
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
82 POP1interactor40.6670.667POP1 (PF06978, IPR009723): Ribonucleases P/MRP protein subunit POP1
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
83 PSIP1oncoprotein21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BEX (PF04538, IPR021156): Brain expressed X-linked like family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
84 PTF1Ainteractor30.6670.667HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
85 RANGAP1protein found in more fusions60.5003.667RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
86 RCC1interactor40.6671.667RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
87 RECQLoncoprotein21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Lipoprotein_3 (PF00938, IPR001595): Lipoprotein
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
88 RITA1suppressor21.0000RITA (PF17066, IPR031418): RBPJ-interacting and tubulin associated protein
89 RND3suppressor31.0000Ras (PF00071, IPR001806, SM00173): Ras family
90 RNF20interactor40.6671.000Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
91 RPA2oncoprotein140.19857.869RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
92 RPS6KA6suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
93 RUNX1T1oncoprotein60.8001.167NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
94 RUNX3suppressor21.0000Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
95 SAMD1interactor30.6670.667CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
96 SART3protein found in more fusions200CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
97 SATB1oncoprotein70.4768.900CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
98 SATB2interactor21.0000CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
99 SEPSECSinteractor21.0000SepSecS (PF05889, IPR008829): O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
100 SFMBT1interactor100MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TIMELESS_C (PF05029, IPR007725): Timeless protein C terminal region
SLED (PF12140, IPR021987): SLED domain
101 SIN3Aoncoprotein160.28365.419Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
102 SMARCA1interactor30.6670.286ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DBINO (PF13892, IPR020838): DNA-binding domain
103 SMARCA4suppressor130.33336.988DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
104 SMARCA5interactor110.40014.477HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DBINO (PF13892, IPR020838): DNA-binding domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
105 SND1interactor40.6671.067TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
106 SNW1protein found in more fusions180.27975.619SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
107 SPENoncoprotein50.5004.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
108 TBPinteractor100.33318.717TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
109 TFAP4oncoprotein80.42913.133DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
110 TPM1protein found in more fusions40.6670.667Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
111 TPM2protein found in more fusions50.5002.667DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
112 TPX2interactor21.0000Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
113 TXNDC5interactor60.4676.067Thioredoxin (PF00085, IPR013766): Thioredoxin
114 USP47interactor21.0000Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
115 USP7oncoprotein60.5004.000MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
116 WDR70interactor21.0000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
117 XPO1interactor190.158129.833CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
118 ZBTB10interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
119 ZMIZ1oncoprotein40.6671.667zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
120 ZNF143interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
CopK (PF11525, IPR021604): Copper resistance protein K
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
121 ZNF268interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
122 ZNF589interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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