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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins21 (50.00 %)
The number (and %) of the tumor suppressors11 (26.19 %)
Total number of binary PPIs (saturation %)218 (25.32 %)
The number (and %) of affected PPIs40 (18.35 %)
The number of possible different fusions17
PPI diameter4
PPI radius2
The average degree of PPI9.000
Assortativity coefficient-0.1934
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients4 (9.52 %)
The number (and %) of a zero Betweenness Centrality8 (19.05 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions KDM1A (see 2 fusions); KAT5 (see 3 fusions); FOS (see 4 fusions); STAT3 (see 2 fusions); RXRA (see 2 fusions); COPS5 (see 1 fusions); CTBP1 (see 2 fusions); MAPRE1 (see 1 fusions); EP300 (see 1 fusions); NFKB1 (see 2 fusions); NCOA1 (see 2 fusions); FYN (see 1 fusions); RCOR1 (see 2 fusions); CTBP2 (see 2 fusions); STAT1 (see 1 fusions); GSK3B (see 1 fusions); BAG2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BCL3parental protein390.198776.432Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
2 IGHparental protein100NA
3 BAG2protein found in more fusions31.0000IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
4 BARD1suppressor50.8330.250BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5 BCL10suppressor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
6 COPS5protein found in more fusions120.54513.672JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 CTBP1protein found in more fusions110.5569.5732-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
8 CTBP2protein found in more fusions50.8330.3332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
9 CTNNB1oncoprotein150.40039.932Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
10 CYLDsuppressor31.0000CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
11 EP300oncoprotein230.381102.213Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
12 ESR1suppressor200.44453.842Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13 FBXW8interactor30.6670.286WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 FOSoncoprotein80.8570.952bZIP_1 (PF00170, IPR004827): bZIP transcription factor
15 FYNoncoprotein60.6001.702Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 GSK3Bsuppressor100.5569.505Pkinase (PF00069, IPR000719): Protein kinase domain
17 GTF2A1oncoprotein21.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
18 GTF2Binteractor70.8571.528Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
19 HDAC1suppressor170.47526.847FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20 HDAC3suppressor150.47325.102Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HDAC6oncoprotein110.40016.877Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
22 HSPA4interactor130.33335.426Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
23 JUNoncoprotein140.57714.590bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
24 KAT5suppressor130.50016.540MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
25 KDM1Aprotein found in more fusions120.54512.071Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
26 MAPRE1oncoprotein80.5245.956CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
27 N4BP2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
DUF1771 (PF08590, IPR013899, SM01162): Domain of unknown function (DUF1771)
RyR (PF02026, IPR003032): RyR domain
Smr (PF01713, IPR002625, SM00463): Smr domain
AAA_22 (PF13401, IPR003593): AAA domain
AAA_33 (PF13671): AAA domain
28 NCOA1oncoprotein130.56187.095DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
29 NFKB1suppressor160.45736.380Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
30 NFKB2oncoprotein50.8330.667Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
31 NR1I3interactor30.33380.000PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
32 PIRinteractor100Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
33 PSMB1interactor100Proteasome (PF00227, IPR001353): Proteasome subunit
34 RCOR1protein found in more fusions80.6673.487DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
35 RELBoncoprotein50.7001.952RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper
RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
36 RUVBL1oncoprotein90.6433.339TIP49 (PF06068, IPR010339): TIP49 C-terminus
37 RUVBL2oncoprotein100.7782.273TIP49 (PF06068, IPR010339): TIP49 C-terminus
38 RXRAoncoprotein110.48978.129zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
39 STAT1suppressor90.7142.881SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
40 STAT3suppressor150.52726.857SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
41 TBL1XR1oncoprotein60.8000.690LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
42 TBPinteractor140.50028.621TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal

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