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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SKA2, FAU (from a repository: Wed Sep 5 17:38:23 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)70
The number (and %) of the onco-proteins17 (24.29 %)
The number (and %) of the tumor suppressors5 (7.14 %)
Total number of binary PPIs (saturation %)971 (40.21 %)
The number (and %) of affected PPIs68 (7.00 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI27.286
Assortativity coefficient0.2410
The network average Clustering coefficient0.712
The number (and %) of a zero Clustering coefficients4 (5.71 %)
The number (and %) of a zero Betweenness Centrality4 (5.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FAU,SKA2 All fusions
Proteins found in more fusions PTBP1 (see 1 fusions); RPS24/RPS23 (see 1 fusions); G3BP1 (see 1 fusions); RPS24/RPS27 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); SERBP1 (see 1 fusions); RPS4X/AHSA1 (see 1 fusions); RALYL (see 1 fusions); COPS5 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FAUparental protein570.540449.913Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
2 SKA2parental protein110.273275.967SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
3 AHSA1protein found in more fusions170.9121.365Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 BYSLinteractor110.691125.141Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
5 CAND1interactor390.81122.499Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 CD81interactor240.9292.154Tetraspannin (PF00335, IPR018499): Tetraspanin family
7 COPS5protein found in more fusions390.72495.423JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
8 COPS6interactor130.818123.369DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
9 CUL1suppressor400.74458.117Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 CUL3protein found in more fusions400.646453.606Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 DCTN1interactor90.250378.120Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
12 DSN1interactor21.0000MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
13 DYNLL1interactor90.39368.679Dynein_light (PF01221, IPR001372): Dynein light chain type 1
14 FN1oncoprotein360.79233.844fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
15 G3BP1protein found in more fusions130.54511.333NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
16 GRB2oncoprotein90.71428.834SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
17 HDLBPoncoprotein30.6670.333BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
18 HMOX2interactor2022.749Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
19 ICAM1oncoprotein220.9870.172Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
20 IGSF8oncoprotein230.9840.262V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
21 IL7Rinteractor70.6671.372fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
22 KIAA0753interactor41.0000MNR (PF15718, IPR031447): Protein moonraker
23 NPM1suppressor470.639119.468Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
24 PA2G4interactor110.58293.630Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
25 PNO1interactor190.8895.247KH_1 (PF00013, IPR004088, SM00322): KH domain
26 PPP2R2Binteractor50.300131.492WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
27 PRKD3interactor100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
28 PTBP1oncoprotein140.6928.269RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
29 PYM1interactor250.8909.385CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Mago-bind (PF09282, IPR015362): Mago binding
AAA_23 (PF13476): AAA domain
30 RALYLprotein found in more fusions3025.781RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
31 RPL11suppressor420.79041.191Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
32 RPL12interactor390.82922.728Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
33 RPL13interactor390.85014.588Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
34 RPL18interactor420.78652.997Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
35 RPL23Ainteractor410.83423.560Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
36 RPL27Ainteractor350.8965.308Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
37 RPL5suppressor410.86812.587Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
38 RPS12interactor360.8818.153Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
39 RPS13interactor450.78428.445Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
40 RPS15interactor380.84114.842Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
41 RPS15Ainteractor410.81027.779Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
42 RPS16interactor440.80223.915Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
43 RPS17interactor310.9253.965Ribosomal_S17e (PF00833, IPR001210): Ribosomal S17
44 RPS18interactor420.81820.923Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
45 RPS19interactor440.78336.811Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
46 RPS2interactor460.74761.008Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
47 RPS20interactor440.73065.324Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
48 RPS23protein found in more fusions440.77924.144Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
49 RPS24protein found in more fusions410.79635.103Fascin (PF06268, IPR022768): Fascin domain
Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
50 RPS25interactor450.78427.839Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
51 RPS26interactor370.81227.096Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
52 RPS27protein found in more fusions410.80936.033Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
53 RPS27Linteractor280.84414.311E7 (PF00527, IPR000148): E7 protein, Early protein
Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
54 RPS28interactor400.84213.623Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
55 RPS29interactor260.9172.793Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
56 RPS3interactor490.689102.773KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
57 RPS4Xprotein found in more fusions460.75162.542KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
58 RPS6interactor450.78528.260Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
59 RPS7interactor420.79726.802Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
60 RPS9interactor430.81522.273Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
61 RPSAinteractor410.77945.694Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
62 SERBP1protein found in more fusions210.64718.622HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
63 SKA1interactor70.66710.576SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
64 SKA3interactor70.66710.576RNA_pol_RpbG (PF16992, IPR031555): DNA-directed RNA polymerase, subunit G
65 SPC24interactor60.66750.023DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
66 SPICE1interactor70.429267.863SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
67 SPTAN1oncoprotein60.9330.182EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
68 TAF7interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
69 TP53suppressor290.796262.202DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
70 TSR1interactor290.805182.024AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein

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