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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)66
The number (and %) of the onco-proteins21 (31.82 %)
The number (and %) of the tumor suppressors6 (9.09 %)
Total number of binary PPIs (saturation %)241 (11.24 %)
The number (and %) of affected PPIs65 (26.97 %)
The number of possible different fusions19
PPI diameter5
PPI radius3
The average degree of PPI6.212
Assortativity coefficient-0.2290
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients10 (15.15 %)
The number (and %) of a zero Betweenness Centrality18 (27.27 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions STAT3 (see 2 fusions); AP2M1 (see 3 fusions); EWSR1 (see 2 fusions); WDR77 (see 1 fusions); SRPK2 (see 1 fusions); G3BP1 (see 1 fusions); VCP (see 4 fusions); LUC7L (see 1 fusions); CREBZF (see 1 fusions); PRMT5 (see 2 fusions); PRPF19 (see 2 fusions); PIK3R1 (see 1 fusions); STAT1 (see 1 fusions); RACK1 (see 3 fusions); CTNNBL1 (see 1 fusions); PRPF3 (see 1 fusions); SNW1 (see 1 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CTNNBL1parental protein520.0852687.865Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DASH_Dad4 (PF08650, IPR013959): DASH complex subunit Dad4
CTNNBL (PF08216, IPR013180, SM01156): Catenin-beta-like, Arm-motif containing nuclear
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
2 IFNAR1parental protein130.115314.356Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
3 ACTA1interactor100Actin (PF00022, IPR004000, SM00268): Actin
4 AICDAinteractor60.6002.965APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
5 AP2M1protein found in more fusions4056.682Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6 BCAS2interactor90.8611.600BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2)
ZapB (PF06005, IPR009252): Cell division protein ZapB
7 BEX3interactor200BEX (PF04538, IPR021156): Brain expressed X-linked like family
8 BTRConcoprotein50.50021.636WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 BUD31interactor40.8330.200G10 (PF01125, IPR001748): G10 protein
10 CATIPinteractor200RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
11 CDC5Linteractor160.44852.161OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12 CDCA7Linteractor31.0000zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
13 CREBZFprotein found in more fusions200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
14 CWC15interactor70.7623.821Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
15 CYP1A1oncoprotein21.0000p450 (PF00067, IPR001128): Cytochrome P450
16 DDX21interactor70.42915.289CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
17 EWSR1oncoprotein80.28644.308RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FBXW11interactor60.30043.417WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 G3BP1protein found in more fusions31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
20 HECW2interactor70.4676.917C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
21 HIST4H4interactor30.33314.908CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
22 HNRNPKoncoprotein120.236184.978ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
23 HOXB5interactor100DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
24 HSPA4interactor50.7002.149Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
25 IFNAR2interactor50.6675.695Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
26 IKinteractor60.30036.628Lsm_interact (PF05391, IPR008669): Lsm interaction motif
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
RED_N (PF07808, IPR012916): RED-like protein N-terminal region
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
27 KIF3Ainteractor21.0000Bacillus_HBL (PF05791, IPR008414): Bacillus haemolytic enterotoxin (HBL)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Fez1 (PF06818): Fez1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
28 KPNA1interactor110.36455.719Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
29 KPNA2interactor110.364100.197Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
30 LDOC1oncoprotein31.0000DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
31 LUC7Lprotein found in more fusions60.5003.567LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
32 MAPK8IP2interactor40.66720.447BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
33 MED4interactor40.33341.012Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
34 MEOX2interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
35 NPM1suppressor100.222174.708Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
36 NSRP1interactor21.0000Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF2040 (PF09745, IPR018612): Coiled-coil domain-containing protein 55 (DUF2040)
Macoilin (PF09726, IPR019130): Transmembrane protein
PepSY_2 (PF13670, IPR025711): Peptidase propeptide and YPEB domain
37 PIK3R1oncoprotein50.33339.749RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
38 PLRG1interactor120.59192.757WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39 PPP1R8interactor40.5003.000FHA (PF00498, IPR000253, SM00240): FHA domain
40 PRDM4suppressor200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
41 PRKD2interactor100ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
42 PRMT1interactor70.06780.195Methyltransf_25 (PF13649): Methyltransferase domain
43 PRMT5protein found in more fusions80.23876.531PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
44 PRPF19protein found in more fusions140.55126.441Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45 PRPF3protein found in more fusions100.6948.548DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
PRP3 (PF08572, IPR013881): pre-mRNA processing factor 3 (PRP3)
PWI (PF01480, IPR002483, SM00311): PWI domain
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
46 PRPF31interactor110.26781.303Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
47 RACK1suppressor80.19097.153WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
48 RBM39oncoprotein120.51524.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
49 RBM45interactor41.0000RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
50 SF3A2interactor150.37167.356Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
51 SNW1protein found in more fusions160.34367.569SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
52 SOCS1suppressor30.6671.786SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
53 SPP1oncoprotein21.0000Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
54 SRPK2oncoprotein70.40011.410DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
55 STAMBPinteractor100USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
56 STAT1suppressor100.139414.613SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
57 STAT2oncoprotein40.50035.883SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT2_C (PF12188, IPR022756): Signal transducer and activator of transcription 2 C terminal
58 STAT3suppressor50.33339.426SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
59 STAT6oncoprotein30.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal
60 THAP2interactor100THAP (PF05485, IPR006612, SM00980): THAP domain
61 TYK2interactor70.200119.032Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
62 U2SURPinteractor40.8330.200cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
Surp (PF01805, IPR000061, SM00648): Surp module
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
FAM176 (PF14851): FAM176 family
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
63 VCPprotein found in more fusions120.255121.419AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
64 WBP11interactor40.6671.833BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
65 WDR77oncoprotein40.6671.871LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
66 ZCCHC10interactor40.6671.700Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle

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