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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IDH3G, UBE2Q2P2 (from a repository: Thu May 23 09:51:37 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)63 (19.38 %)
The number (and %) of affected PPIs24 (38.10 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI4.462
Assortativity coefficient-0.3528
The network average Clustering coefficient0.641
The number (and %) of a zero Clustering coefficients2 (7.69 %)
The number (and %) of a zero Betweenness Centrality9 (34.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2Q2P2,IDH3G All fusions
Proteins found in more fusions MYC (see 1 fusions); BCOR (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2Q2P2interactor000NA
2 IDH3Gparental protein240.123423.000Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
3 ACO2interactor21.0000Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ADRB2interactor60.7002.3337tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AGPSinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
6 AHSA1interactor21.0000Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
7 BCORoncoprotein31.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
8 CDV3interactor40.6672.000TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
9 EDF1interactor100MBF1 (PF08523, IPR013729): Multiprotein bridging factor 1
HTH_3 (PF01381, IPR001387, SM00530): Helix-turn-helix
10 HNRNPKoncoprotein60.4005.167ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
11 IDH1suppressor50.7003.000Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
12 IDH2oncoprotein50.9000.500Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
13 IDH3Ainteractor80.46413.333Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
14 IDH3Binteractor60.7332.333Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
15 KPNA2interactor30.6670.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
16 MYConcoprotein60.5004.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
17 POU5F1oncoprotein50.5002.667Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
18 PPP1R12Ainteractor21.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
19 PQBP1interactor30.6671.000WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
20 RAB8Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
21 SBDSoncoprotein40.5002.667SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
22 SCP2interactor50.5005.000SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
23 SPRinteractor30.6670.667adh_short (PF00106, IPR002198): short chain dehydrogenase
24 SUGP1interactor70.38112.333G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): G-patch domain
25 TIMM44interactor50.6003.333Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
26 UQCRFS1P1interactor21.0000NA

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