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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IDE, XPNPEP3 (from a repository: Fri Jul 26 02:50:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)75
The number (and %) of the onco-proteins20 (26.67 %)
The number (and %) of the tumor suppressors7 (9.33 %)
Total number of binary PPIs (saturation %)295 (10.63 %)
The number (and %) of affected PPIs77 (26.10 %)
The number of possible different fusions17
PPI diameter3
PPI radius2
The average degree of PPI6.853
Assortativity coefficient-0.3665
The network average Clustering coefficient0.435
The number (and %) of a zero Clustering coefficients14 (18.67 %)
The number (and %) of a zero Betweenness Centrality21 (28.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: IDE,XPNPEP3 All fusions
Proteins found in more fusions STAT3 (see 2 fusions); BAG3 (see 4 fusions); UBR5 (see 4 fusions); CISD3 (see 1 fusions); IDE/XPNPEP3 (see 1 fusions); NR3C1 (see 8 fusions); OPA3 (see 2 fusions); CTTN (see 1 fusions); FAM136A (see 1 fusions); CUL3 (see 1 fusions); UBC (see 7 fusions); ATP6V1C1 (see 3 fusions); ATP5A1 (see 1 fusions); PPM1K (see 1 fusions); STAT1 (see 1 fusions); VIM (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IDEparental protein590.0563420.816Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
2 XPNPEP3parental protein190.144747.781AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
3 ARoncoprotein31.0000Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4 ARFIP1interactor90.47221.028Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ATP5A1protein found in more fusions120.40038.397ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
6 ATP6V1C1protein found in more fusions110.62210.217V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
7 BAG3oncoprotein60.10027.731BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 C15orf48interactor80.53629.079B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
9 C1QBPinteractor220.169240.359MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
10 C2orf47interactor60.8003.402Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
11 CARSoncoprotein40.6672.100tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
12 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
13 CHCHD1interactor31.0000CHCH (PF06747, IPR010625): CHCH domain
UCR_hinge (PF02320, IPR023184): Ubiquinol-cytochrome C reductase hinge protein
14 CHCHD2interactor170.383109.685CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
15 CISD3protein found in more fusions80.28625.664zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
16 COQ7interactor70.6009.084COQ7 (PF03232, IPR011566): Ubiquinone biosynthesis protein COQ7
17 COQ9interactor130.36476.183COQ9 (PF08511, IPR013718): COQ9
18 CTTNoncoprotein110.55625.392FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19 CUL3protein found in more fusions160.238120.915Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
20 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
21 DOHHinteractor30.33317.290TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_2 (PF13646): HEAT repeats
22 DYRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
23 ECH1interactor190.111192.720ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
24 ECI2interactor60.40027.150ACBP (PF00887, IPR000582): Acyl CoA binding protein
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
25 FAM136Aprotein found in more fusions60.4009.084DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
26 FAM98Binteractor40.5004.864DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465)
27 GPAMinteractor301.887Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
28 GSPT1oncoprotein60.60013.485GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
29 GSPT2interactor80.67921.664GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
30 HOXC9interactor100Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 HYLS1interactor100HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
32 IFIH1interactor100ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
33 IGF1suppressor100Insulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
DUF2865 (PF11064, IPR021293): Protein of unknown function (DUF2865)
34 IGF2oncoprotein100IGF2_C (PF08365, IPR013576): Insulin-like growth factor II E-peptide
Insulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
35 LACE1interactor50.8330.400AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
36 LDHAinteractor60.50011.942Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
37 LDHBinteractor70.46712.384Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
38 LYRM1interactor302.317Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
39 LYRM4interactor50.5004.603Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
40 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
41 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
42 NAPRTinteractor31.0000NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
43 NESinteractor50.20031.160Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
44 NIT1interactor509.084CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
45 NR3C1protein found in more fusions31.0000GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
46 NSFL1Cinteractor30.6673.128SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
47 NT5DC2interactor50.2007.9265_nucleotid (PF05761, IPR008380): 5' nucleotidase family
48 NTRK1oncoprotein250.178315.050I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
49 OBSL1interactor90.17928.160BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
50 OPA3protein found in more fusions50.5004.603IL11 (PF07400, IPR020438): Interleukin 11
OPA3 (PF07047, IPR010754): Optic atrophy 3 protein (OPA3)
51 PAFAH1B2oncoprotein80.35741.846Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
52 PAK5interactor60.7006.384PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
53 PAWRsuppressor60.8001.909ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
54 PEX5interactor40.5004.278TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
55 POLDIP2interactor120.21245.920DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
56 PPCSinteractor21.0000DFP (PF04127, IPR007085): DNA / pantothenate metabolism flavoprotein
Collectrin (PF16959, IPR031588): Renal amino acid transporter
57 PPM1Kprotein found in more fusions50.5008.039PP2C (PF00481, IPR001932): Protein phosphatase 2C
58 PRMT3interactor40.6671.056PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
59 PUS1interactor100PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
60 PUS7interactor40.6672.774R3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
61 RPEinteractor31.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
62 SCLYinteractor21.0000Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
63 SHMT1interactor100.6677.944SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
64 SHMT2interactor180.294142.916SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
65 SIRT4suppressor100SIR2 (PF02146, IPR003000): Sir2 family
66 SPRYD4interactor50.5003.800SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
67 STAT1suppressor110.60013.161SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
68 STAT3suppressor120.38241.042SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
69 TBC1D15interactor70.6675.368Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
70 THOP1interactor21.0000Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
71 UBCprotein found in more fusions110.40047.439ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
72 UBR5protein found in more fusions100.22261.679CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
73 UCHL5oncoprotein41.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
74 UQCRC2oncoprotein80.46419.087Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
75 VIMsuppressor60.40014.621Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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