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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DCDC1, ITGA2 (from a repository: Tue Mar 28 10:17:20 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins6 (28.57 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)34 (16.19 %)
The number (and %) of affected PPIs19 (55.88 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.762
Assortativity coefficient-0.6056
The network average Clustering coefficient0.447
The number (and %) of a zero Clustering coefficients10 (47.62 %)
The number (and %) of a zero Betweenness Centrality19 (90.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DCDC1,ITGA2 All fusions
Proteins found in more fusions COL1A1 (see 11 fusions); LGALS3 (see 2 fusions); GAN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DCDC1parental protein100DCX (PF03607, IPR003533, SM00537): Doublecortin
DUF711 (PF05167, IPR007841): Uncharacterised ACR (DUF711)
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
2 ITGA2parental protein180.065267.000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
3 ALBinteractor21.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 ATF2oncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 AUP1interactor100CUE (PF02845, IPR003892, SM00546): CUE domain
6 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
7 CD46oncoprotein21.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188)
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
8 COL1A1oncoprotein31.0000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
9 ERGIC1interactor100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
10 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
11 ITGB1suppressor80.32119.000EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
12 LAMA1interactor31.0000Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
13 LGALS3oncoprotein41.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
14 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 MMP1interactor100FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
16 PDIA3interactor31.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
17 PSMD4interactor21.0000UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
18 RABIFinteractor100Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
19 RSRP1oncoprotein100RSRP (PF17069): Arginine/Serine-Rich protein 1
20 SHARPINinteractor200DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
21 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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