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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPN21, APOA2 (from a repository: Fri Aug 9 12:21:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins4 (20.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)41 (21.58 %)
The number (and %) of affected PPIs18 (43.90 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI3.300
Assortativity coefficient-0.3700
The network average Clustering coefficient0.668
The number (and %) of a zero Clustering coefficients3 (15.00 %)
The number (and %) of a zero Betweenness Centrality14 (70.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: APOA2,PTPN21 All fusions
Proteins found in more fusions APOD (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 APOA2parental protein140.154106.333ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
2 PTPN21parental protein40.16710.000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ABCA13interactor21.0000ABC_tran (PF00005, IPR003439): ABC transporter
ApoLp-III (PF07464, IPR010009): Apolipophorin-III precursor (apoLp-III)
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
4 ALBinteractor31.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 APOA1interactor120.20043.667ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
6 APODprotein found in more fusions40.6670.667Lipocalin_2 (PF08212, IPR000566): Lipocalin-like domain
7 APOFinteractor21.0000Apolipo_F (PF15148, IPR026114): Apolipoprotein F
8 BMXinteractor21.0000BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
9 CATSPER1interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
MMM1 (PF10296, IPR019411): Maintenance of mitochondrial morphology protein 1
10 CREB3interactor50.5002.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
11 DGAT1interactor31.0000MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
12 GDPD1interactor31.0000GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
13 JUNoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
14 KIF1Cinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
15 LCATinteractor21.0000LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
16 PARD6Binteractor100PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
17 PLTPinteractor21.0000LBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
LBP_BPI_CETP_C (PF02886, IPR001124, SM00329): LBP / BPI / CETP family, C-terminal domain
18 SCARB1oncoprotein21.0000CD36 (PF01130, IPR002159): CD36 family
19 SRConcoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 VKORC1interactor40.6670.667VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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