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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KIF26B, BIRC5 (from a repository: Thu Feb 8 05:19:26 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins21 (36.21 %)
The number (and %) of the tumor suppressors10 (17.24 %)
Total number of binary PPIs (saturation %)240 (14.52 %)
The number (and %) of affected PPIs58 (24.17 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI7.310
Assortativity coefficient-0.1972
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients8 (13.79 %)
The number (and %) of a zero Betweenness Centrality15 (25.86 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PRKDC (see 3 fusions); BUB1 (see 1 fusions); USF2 (see 1 fusions); HSP90AA1 (see 2 fusions); CDK6 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KIF26Bparental protein200.116593.548Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Microtub_bd (PF16796, IPR031852): Microtubule binding
2 BIRC5parental protein380.1431207.223BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
3 AIPsuppressor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
4 ANKLE2interactor21.0000Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
5 ASB8interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 AURKAoncoprotein110.48923.124Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
7 AURKBinteractor130.42447.380Pkinase (PF00069, IPR000719): Protein kinase domain
8 AURKCinteractor50.50027.978Pkinase (PF00069, IPR000719): Protein kinase domain
9 BECN1suppressor80.42925.941APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
10 BIRC2oncoprotein100.63915.610BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
11 BIRC3oncoprotein100.63915.610BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 BMI1oncoprotein80.28689.303zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
13 BUB1oncoprotein41.0000Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
14 CASKinteractor60.60013.016L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
15 CASP3interactor120.47348.086Peptidase_C14 (PF00656, IPR011600): Caspase domain
16 CASP7interactor71.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 CASP9oncoprotein61.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
18 CBLL1oncoprotein100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 CDCA8interactor80.61914.544Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
20 CDK1oncoprotein70.53318.009Pkinase (PF00069, IPR000719): Protein kinase domain
21 CDK2suppressor130.348207.080Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
22 CDK4oncoprotein40.6677.593Pkinase (PF00069, IPR000719): Protein kinase domain
23 CDK5oncoprotein60.50011.554Pkinase (PF00069, IPR000719): Protein kinase domain
24 CDK6suppressor70.53317.318Pkinase (PF00069, IPR000719): Protein kinase domain
25 DIABLOsuppressor70.8005.969Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
26 DLG1suppressor60.40035.355L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
27 ELAVL1oncoprotein210.200306.370RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
28 EVI5interactor40.6672.888bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
29 F2RL1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
30 FBXL7oncoprotein100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
31 H2AFXsuppressor80.46433.852Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
32 HDAC6oncoprotein100.55612.445Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
33 HIST1H2BGoncoprotein41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
34 HIST2H3Cinteractor50.7002.709Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
35 HIST3H3interactor50.60019.448Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
36 HSP90AA1oncoprotein200.246215.955HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
37 INCENPinteractor80.5369.829ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
38 KCNJ6interactor2012.490IRK (PF01007, IPR016449): Inward rectifier potassium channel
39 LIN7Cinteractor60.40054.363His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
40 MAP4K4interactor50.40014.284CNH (PF00780, IPR001180, SM00036): CNH domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM165 (PF14981, IPR028023): FAM165 family
SOBP (PF15279, IPR026092): Sine oculis-binding protein
FAM60A (PF15396, IPR026065): Protein Family FAM60A
41 MDC1suppressor50.9000.500FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
42 MPP7interactor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
43 MX1interactor200Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
44 NEDD4suppressor60.30037.921Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
45 NTRK1oncoprotein210.211296.534I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46 PARK2suppressor120.255101.456IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
47 PPP1CConcoprotein80.25067.708Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
48 PRKDCprotein found in more fusions120.47345.906FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
49 RANoncoprotein50.7004.160Ras (PF00071, IPR001806, SM00173): Ras family
50 TRAF2interactor80.42991.548MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
51 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
52 USF2protein found in more fusions200DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
53 USP9Xinteractor70.52424.647DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
54 WBP11interactor50.40017.093BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
55 XIAPinteractor100.69419.013BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
56 XPO1interactor130.37298.747CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
57 XRCC6oncoprotein80.4769.894Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
58 ZC3H13interactor31.0000FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial

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