Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TSTD3, BIRC5 (from a repository: Mon Aug 12 20:49:24 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins16 (41.03 %)
The number (and %) of the tumor suppressors7 (17.95 %)
Total number of binary PPIs (saturation %)151 (20.38 %)
The number (and %) of affected PPIs38 (25.17 %)
The number of possible different fusions8
PPI diameter2
PPI radiusinf
The average degree of PPI6.769
Assortativity coefficient-0.3127
The network average Clustering coefficient0.545
The number (and %) of a zero Clustering coefficients6 (15.38 %)
The number (and %) of a zero Betweenness Centrality12 (30.77 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TSTD3,BIRC5 All fusions
Proteins found in more fusions BECN1 (see 1 fusions); CASP7 (see 1 fusions); PRKDC (see 2 fusions); AURKA (see 1 fusions); USF2 (see 1 fusions); HSP90AA1 (see 6 fusions); PARK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TSTD3interactor000Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
2 BIRC5parental protein380.143869.367BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
3 AIPsuppressor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
4 AURKAoncoprotein110.48915.733Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 AURKBinteractor130.42426.333Pkinase (PF00069, IPR000719): Protein kinase domain
6 AURKCinteractor40.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
7 BECN1suppressor70.6003.067APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
8 BIRC2oncoprotein90.7144.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 BIRC3oncoprotein90.7144.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 CASP3interactor120.47324.300Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CASP7protein found in more fusions71.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
12 CASP9oncoprotein61.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CDCA8interactor80.6195.067Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
14 CDK2suppressor80.4297.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
16 DIABLOsuppressor60.8001.000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
17 ELAVL1oncoprotein150.26455.033RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 EVI5interactor40.6671.067bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
19 F2RL1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
20 FBXL7oncoprotein100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
21 H2AFXsuppressor70.5246.733Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
22 HDAC6oncoprotein90.5367.633Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
23 HIST1H2BGoncoprotein41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24 HIST2H3Cinteractor50.7002.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
25 HIST3H3interactor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
26 HSP90AA1oncoprotein150.30850.967HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
27 INCENPinteractor80.5368.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
28 KCNJ6interactor100IRK (PF01007, IPR016449): Inward rectifier potassium channel
29 MDC1suppressor50.9000.500FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
30 PARK2suppressor80.4765.600IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 PPP1CConcoprotein50.6001.967Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 PRKDCprotein found in more fusions100.5568.533FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
33 RANoncoprotein40.6671.067Ras (PF00071, IPR001806, SM00173): Ras family
34 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
35 USF2protein found in more fusions200DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
36 USP9Xinteractor60.6006.000DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
37 XIAPinteractor90.7503.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
38 XPO1interactor100.46716.367CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
39 XRCC6oncoprotein70.4673.967Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

B a c k    t o    T o p ⇑