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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPS10, HP (from a repository: Thu Feb 16 23:59:27 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins11 (19.64 %)
The number (and %) of the tumor suppressors4 (7.14 %)
Total number of binary PPIs (saturation %)212 (13.77 %)
The number (and %) of affected PPIs56 (26.42 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI7.036
Assortativity coefficient-0.1578
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients6 (10.71 %)
The number (and %) of a zero Betweenness Centrality16 (28.57 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions NDUFS3 (see 1 fusions); GRB2 (see 1 fusions); TGM2 (see 4 fusions); BAG3 (see 4 fusions); TBL1X (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HPparental protein220.0651031.448Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
2 MRPS10parental protein340.2141136.965Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
3 ALBinteractor30.33364.367Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 ATP7Binteractor21.0000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
5 BAG3oncoprotein70.133205.147BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 C1QBPinteractor90.50013.319MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
7 CISD3interactor41.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
8 DAP3interactor110.57814.132DAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
9 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 ELAVL1oncoprotein110.222473.564RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 EXOSC9interactor100RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
12 GADD45Gsuppressor100Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
13 GDPD1interactor30.6673.367GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
14 GRB2oncoprotein60.40018.204SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
15 HBBinteractor21.0000Globin (PF00042, IPR000971): Globin
16 HNRNPA1interactor140.397183.821RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
17 ICE2interactor31.0000NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
18 ILF3oncoprotein110.47329.143dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
19 LAMC3interactor100DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3774 (PF12609, IPR022251): Wound-induced protein
20 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
21 MOV10interactor120.39428.437AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
22 MRPL14interactor50.8000.786Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
23 MRPL23interactor60.8000.869Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
24 MRPL24interactor100.51165.293KOW (PF00467, IPR005824, SM00739): KOW motif
ribosomal_L24 (PF17136): Ribosomal proteins 50S L24/mitochondrial 39S L24
25 MRPL58interactor150.37153.542RF-1 (PF00472, IPR000352): RF-1 domain
26 MRPS14interactor120.39429.526Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
27 MRPS31interactor110.54517.672MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
28 MRPS5interactor170.36869.361Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
29 MVPoncoprotein50.33338.307Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
30 NDUFS3protein found in more fusions90.39313.189Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
31 NOL12interactor50.6001.675DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
32 NXF1interactor120.36450.139NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
33 POU5F1oncoprotein31.0000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
34 RBBP6oncoprotein30.33328.893DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
35 RPL11suppressor100.622407.162Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
36 RPL23Ainteractor80.8571.150Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
37 RPL9interactor90.7784.541Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
38 RPS18interactor80.7146.710Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
39 RPS2interactor130.48761.603Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
40 RPS5interactor120.51531.541Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
41 RXRBinteractor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
42 SDHBsuppressor21.0000Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
43 SHMT2interactor40.6671.000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
44 SMAD3oncoprotein50.33338.307MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
45 SORT1interactor40.50026.495Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
46 TBL1Xprotein found in more fusions31.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
47 TGM2protein found in more fusions40.6670.667Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
48 TP63suppressor31.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
49 TRA2Ainteractor90.361113.275DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
50 TRMT10Binteractor50.8000.556tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
51 TUFMinteractor130.47447.894GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
52 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
53 WASLinteractor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
54 XRN2interactor50.6003.122XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
55 ZC3H3interactor80.5006.411zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
56 ZNF707interactor50.9000.400KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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