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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)134
The number (and %) of the onco-proteins46 (34.33 %)
The number (and %) of the tumor suppressors19 (14.18 %)
Total number of binary PPIs (saturation %)873 (9.80 %)
The number (and %) of affected PPIs136 (15.58 %)
The number of possible different fusions31
PPI diameter4
PPI radius2
The average degree of PPI12.209
Assortativity coefficient-0.2653
The network average Clustering coefficient0.520
The number (and %) of a zero Clustering coefficients4 (2.99 %)
The number (and %) of a zero Betweenness Centrality17 (12.69 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HNF4A,HINT1 All fusions
Proteins found in more fusions VDR (see 2 fusions); SMAD4 (see 3 fusions); GSTO2 (see 1 fusions); TKT (see 5 fusions); MED21 (see 1 fusions); RUVBL1 (see 1 fusions); FOXO1 (see 3 fusions); MAPK1 (see 2 fusions); U2AF2 (see 2 fusions); HDAC7 (see 1 fusions); HDAC4 (see 1 fusions); NCOA1 (see 2 fusions); ENO1/ENO3 (see 1 fusions); HINT1 (see 3 fusions); NCOA6 (see 1 fusions); OFD1 (see 5 fusions); PCBD1 (see 1 fusions); SP1 (see 1 fusions); SREBF2 (see 2 fusions); SREBF1 (see 1 fusions); CREBBP (see 6 fusions); HNF4A (see 1 fusions); EWSR1 (see 1 fusions); KAT5 (see 3 fusions); COPS5 (see 1 fusions); OXCT1 (see 1 fusions); PRDX6 (see 2 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HNF4Aparental protein640.1443520.219zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
2 HINT1parental protein720.1215466.339HIT (PF01230, IPR001310): HIT domain
3 ACTL6Ainteractor80.57123.659Actin (PF00022, IPR004000, SM00268): Actin
4 AKR1B1suppressor150.56221.610Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 AKR1B10interactor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
6 AKR1B15interactor80.7506.886Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7 ANP32Boncoprotein30.3335.901FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
8 ARoncoprotein350.273432.563Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
9 ARHGDIAinteractor90.46415.552Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
10 BTRConcoprotein150.253244.012WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
11 CDC16interactor30.33325.341Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
12 CDC34oncoprotein50.6670.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
13 CDK9protein found in more fusions120.345172.796Pkinase (PF00069, IPR000719): Protein kinase domain
14 COPS5protein found in more fusions200.170634.129JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CREBBPsuppressor310.313372.375Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16 CTNNB1oncoprotein190.304462.828Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
17 DHX36interactor40.3339.432DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 DUTinteractor150.50526.573dUTPase (PF00692, IPR008180): dUTPase
19 ENO1oncoprotein260.394251.037Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
20 ENO2interactor240.53654.120Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
21 ENO3protein found in more fusions200.66818.501Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
22 EWSR1oncoprotein220.205758.407RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 EXT2suppressor40.6671.000Exostosin (PF03016, IPR004263): Exostosin family
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
24 FABP3suppressor40.8330.118Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
25 FABP5interactor150.70514.186Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
26 FABP7interactor60.6001.149Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
27 FKBP1Ainteractor220.46286.973FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
28 FKBP1Binteractor110.8185.193FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
29 FKBP2interactor140.637161.214FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
30 FKBP7interactor51.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
31 FOXO1suppressor100.6116.350K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
32 GPS2oncoprotein80.50011.022G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
33 GPX4interactor180.51648.306GSHPx (PF00255, IPR000889): Glutathione peroxidase
34 GSTO2protein found in more fusions51.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
35 GSTT1suppressor21.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
36 GTF2Binteractor60.6672.400Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
37 GTF2H1oncoprotein31.0000BSD (PF03909, IPR005607, SM00751): BSD domain
PH_TFIIH (PF08567, IPR013876): TFIIH p62 subunit, N-terminal domain
38 HDAC3suppressor190.255269.826Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
39 HDAC4oncoprotein160.42967.805Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
40 HDAC7protein found in more fusions90.57167.464Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
41 HDAC9interactor60.40037.305Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
42 HSPA4Linteractor70.7144.952HSP70 (PF00012, IPR013126): Hsp70 protein
43 HSPE1interactor210.457149.662Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
44 KAT5suppressor150.363248.260MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
45 LEF1oncoprotein70.42972.739CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
46 MAPK1oncoprotein130.63633.250Pkinase (PF00069, IPR000719): Protein kinase domain
47 MAPK3oncoprotein140.410208.062Pkinase (PF00069, IPR000719): Protein kinase domain
48 MDM2oncoprotein210.268424.623Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
49 MED1interactor220.433364.801Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
50 MED10interactor91.0000Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
51 MED14interactor150.629104.337Med14 (PF08638, IPR013947): Mediator complex subunit MED14
52 MED16interactor120.8034.459WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
53 MED17oncoprotein140.70324.123Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
54 MED21protein found in more fusions160.64836.176Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
55 MED23interactor180.49777.617Med23 (PF11573, IPR021629): Mediator complex subunit 23
56 MED24interactor140.67022.177Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
57 MED7interactor120.78816.932Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
58 MIFoncoprotein80.47643.111MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
59 MITFoncoprotein40.33331.454HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
60 MTAPsuppressor40.6671.333PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
61 NCOA1oncoprotein170.44270.593DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
62 NCOA2oncoprotein110.58215.915DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
63 NCOA6oncoprotein150.48448.611DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Presenilin (PF01080, IPR001108): Presenilin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
64 NCOR2oncoprotein130.44947.728CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
65 NME1-NME2interactor190.52651.295NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
66 NME2interactor190.471175.252NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
67 NPPAinteractor100ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide
68 NR0B2suppressor100.51112.582Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
69 NR1I3interactor90.6674.905PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
70 NR2C2suppressor51.0000Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
71 NRIP1oncoprotein60.4005.494ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
72 NUTF2interactor70.7330.894NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
73 OFD1protein found in more fusions80.28688.712APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
74 OXCT1protein found in more fusions40.6671.690CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
75 PABPC4interactor50.30041.365ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
76 PARK7suppressor130.242251.150DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
77 PCBD1protein found in more fusions31.0000Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
78 PFDN2interactor30.6670.643Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
79 PIAS4interactor70.71414.788CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
80 PIN1suppressor170.331678.678Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
81 PMP2interactor50.9000.154Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
82 PNRC1interactor207.333PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
83 PNRC2interactor100PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
84 PPARGC1Ainteractor160.392161.043Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
85 PPARGC1Binteractor100Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
86 PPIBinteractor120.54568.321Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
87 PRDX2interactor110.41880.256AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
88 PRDX5interactor90.44422.832Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
89 PRDX6protein found in more fusions90.46412.306AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
90 PRMT1interactor80.57123.049Methyltransf_25 (PF13649): Methyltransferase domain
91 PROX1suppressor30.6670.373GET2 (PF08690, IPR028143): GET complex subunit GET2
NifQ (PF04891, IPR006975): NifQ
HPD (PF05044, IPR023082): Homeo-prospero domain
PP_kinase_N (PF13089, IPR025198): Polyphosphate kinase N-terminal domain
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
92 PTGR1interactor31.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
93 RAD50interactor50.40025.429DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
94 RAE1interactor70.381105.995Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
95 RBX1oncoprotein70.46739.534zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
96 RGNinteractor21.0000SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
97 RNF4interactor70.8001.520Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
98 RUVBL1oncoprotein180.294203.788TIP49 (PF06068, IPR010339): TIP49 C-terminus
99 RUVBL2oncoprotein130.333164.870TIP49 (PF06068, IPR010339): TIP49 C-terminus
100 SCLT1oncoprotein30.6670.500DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
101 SIN3Aoncoprotein150.295359.970Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
102 SIRT1suppressor140.39740.349DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
103 SMAD3oncoprotein260.267466.133MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
104 SMAD4suppressor160.40079.570MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
105 SNCGoncoprotein40.6674.633Synuclein (PF01387, IPR001058): Synuclein
106 SP1protein found in more fusions220.390647.359zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
107 SPRinteractor110.45524.316adh_short (PF00106, IPR002198): short chain dehydrogenase
108 SREBF1protein found in more fusions180.43483.694HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
109 SREBF2protein found in more fusions120.49129.782HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
110 STILoncoprotein31.0000STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
111 STIP1interactor210.462117.391TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
112 STK16interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
113 SUB1interactor40.3338.141Dehydrin (PF00257, IPR000167): Dehydrin
PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
114 TADA2Ainteractor90.55629.773SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
115 TAF6interactor60.7334.110CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
116 TAF9interactor90.44439.661TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
117 TAGLNsuppressor180.51633.254Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
118 TAGLN2interactor330.303292.441Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
119 TAGLN3interactor190.52650.387Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
120 TBPinteractor170.44282.411TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
121 TGS1interactor50.6002.735DinI (PF06183, IPR010391): DinI-like family
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Methyltransf_15 (PF09445, IPR019012): RNA cap guanine-N2 methyltransferase
Presenilin (PF01080, IPR001108): Presenilin
122 TKTprotein found in more fusions250.402313.405Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
123 TMEM189-UBE2V1interactor41.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
124 TP53suppressor420.1801480.834DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
125 TXNoncoprotein190.368320.719Thioredoxin (PF00085, IPR013766): Thioredoxin
126 U2AF2protein found in more fusions180.294219.428RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
127 UBE2Iinteractor240.277482.640UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
128 UBE2V1interactor60.6671.216UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
129 UCHL3interactor130.43962.585Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
130 UFC1interactor60.6008.330UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
131 UNKinteractor130.128460.163MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
132 VDRsuppressor220.367108.293zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
133 XPO1interactor170.191287.117CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
134 ZNHIT3interactor21.0000FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
zf-HIT (PF04438, IPR007529): HIT zinc finger

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