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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)135
The number (and %) of the onco-proteins47 (34.81 %)
The number (and %) of the tumor suppressors16 (11.85 %)
Total number of binary PPIs (saturation %)696 (7.69 %)
The number (and %) of affected PPIs134 (19.25 %)
The number of possible different fusions28
PPI diameter4
PPI radius2
The average degree of PPI9.526
Assortativity coefficient-0.2532
The network average Clustering coefficient0.359
The number (and %) of a zero Clustering coefficients24 (17.78 %)
The number (and %) of a zero Betweenness Centrality26 (19.26 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions NTRK1/HNRNPC (see 1 fusions); MAGED1 (see 1 fusions); HSP90AA1 (see 2 fusions); NIN (see 1 fusions); ATXN1 (see 3 fusions); SRPK2 (see 1 fusions); MAPK14 (see 1 fusions); MDM4 (see 2 fusions); MAPT (see 1 fusions); PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); MALT1 (see 1 fusions); SEC23B (see 2 fusions); IMMT (see 4 fusions); SH3KBP1 (see 1 fusions); PDE4D (see 2 fusions); EGFR (see 2 fusions); APC (see 1 fusions); COPS5 (see 1 fusions); HMGB1/HMGB2 (see 1 fusions); HNRNPC (see 1 fusions); UBC (see 1 fusions); APH1A (see 2 fusions); RPA1 (see 1 fusions); CSNK1E (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CSNK1A1parental protein880.0817091.286Pkinase (PF00069, IPR000719): Protein kinase domain
2 HIVEP1parental protein460.0343924.103PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 ACACAinteractor70.28639.398ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region
Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
4 ACTA1interactor50.30013.069Actin (PF00022, IPR004000, SM00268): Actin
5 ADAP1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
6 ALDOBoncoprotein100Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 APCsuppressor120.41836.641APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
8 APH1Aoncoprotein40.6674.488Aph-1 (PF06105, IPR009294): Aph-1 protein
9 APTXinteractor30.33310.909FHA (PF00498, IPR000253, SM00240): FHA domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10 ASGR1interactor100Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
11 ATXN1protein found in more fusions90.14383.994AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
12 ATXN1Linteractor40.3339.740AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
13 AXIN1suppressor110.51113.934Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
14 BACH1interactor80.38135.739BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
15 BCL10suppressor90.53618.266CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
16 BHLHE40interactor90.50030.394Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
17 BNIP3oncoprotein200BNIP3 (PF06553, IPR010548): BNIP3
18 BRCA1suppressor180.191254.517BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
19 BTRConcoprotein270.222782.487WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
20 C1orf111interactor30.6671.248zf-C2H2_4 (PF13894): C2H2-type zinc finger
21 CACNA1Ainteractor2011.012Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
22 CARD11oncoprotein70.46721.336CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
23 CDC25Aoncoprotein80.46421.886M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
24 CDKN2AIPinteractor70.28655.279XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
25 CEP128interactor140.38546.681DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26 CEP135interactor80.42927.642DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPD52 (PF04201, IPR007327): Tumour protein D52 family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
27 CEP170interactor130.308109.515FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
28 CHRM3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GWT1 (PF06423, IPR009447): GWT1
29 CHST15interactor100Sulfotransfer_3 (PF13469): Sulfotransferase family
30 CLK1interactor50.33353.334PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
31 CLTConcoprotein240.293181.485Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
32 COPS5protein found in more fusions240.285328.157JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
33 CPSF6interactor40.66710.104RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
34 CSNK1Dinteractor150.286119.948Pkinase (PF00069, IPR000719): Protein kinase domain
35 CSNK1Eprotein found in more fusions300.217423.809APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
36 DBR1interactor50.600113.047DBR1 (PF05011, IPR007708, SM01124): Lariat debranching enzyme, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
37 DNAJA1interactor110.56444.122DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
38 DYNLL1interactor90.32120.370Dynein_light (PF01221, IPR001372): Dynein light chain type 1
39 DYNLL2interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
40 E2F1suppressor60.6007.036Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
41 EGFRoncoprotein290.204575.245Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
42 ELAVL1oncoprotein300.190747.224RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 EPM2AIP1interactor31.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
44 ERFsuppressor40.5009.596CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Ets (PF00178, IPR000418, SM00413): Ets-domain
MCPVI (PF02993, IPR004243): Minor capsid protein VI
45 FAM170Ainteractor100CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
zf-C2H2_4 (PF13894): C2H2-type zinc finger
46 FAM83Binteractor90.5289.288Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
47 FAM83Dinteractor60.4005.717DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
48 FAM83Ginteractor30.3338.295DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
49 FAM83Hinteractor120.42434.237DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
50 FBXW11interactor220.243406.659WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
51 GAAinteractor207.933Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
52 GLI3oncoprotein30.6671.803zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
53 GNB2interactor80.393140.396WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
54 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
55 GTSE1interactor110.47349.194GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
56 HMGB1oncoprotein50.5003.808HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
57 HMGB2protein found in more fusions50.6008.922HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
58 HMMRinteractor80.42920.185APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
59 HNRNPCprotein found in more fusions160.41076.014APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
60 HPDinteractor21.0000Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
61 HSP90AA1oncoprotein210.311212.310HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
62 HSPA1Ainteractor140.363122.209HSP70 (PF00012, IPR013126): Hsp70 protein
63 HSPA4interactor170.294213.598Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
64 IMMTprotein found in more fusions80.28647.176Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
65 IRF5suppressor305.124IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
66 ITGA4interactor160.32482.034FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
67 KBTBD7interactor3015.058BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
68 KPNA2interactor100.37848.315Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
69 MAGED1protein found in more fusions80.33382.227MAGE (PF01454, IPR002190): MAGE family
70 MALT1oncoprotein70.6674.793Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
71 MAPK14oncoprotein110.244133.466Pkinase (PF00069, IPR000719): Protein kinase domain
72 MAPK8oncoprotein100.222116.958DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
73 MAPTprotein found in more fusions100.44436.344Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
74 MDM2oncoprotein180.287294.688Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
75 MDM4oncoprotein110.37853.560zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
76 MTMR3oncoprotein100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
77 MYO18Ainteractor60.33331.359Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
78 MZT2Ainteractor100MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
79 MZT2Binteractor30.33311.593MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
80 NFATC3oncoprotein30.33312.048DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
81 NFKBIAoncoprotein100.33378.951Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
82 NHLH1interactor204.488HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
83 NINoncoprotein100.50020.640BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
84 NINJ1suppressor100Ninjurin (PF04923, IPR007007): Ninjurin
85 NTRK1oncoprotein380.1561073.261I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
86 NUCB1interactor2015.527DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
87 OCLNinteractor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
88 PCM1oncoprotein140.36376.460FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
89 PDE4Doncoprotein31.0000Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
90 PHLPP1suppressor40.50011.804LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
91 PIP5K1Aoncoprotein100PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
92 PPP1CConcoprotein120.57617.186Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
93 PPP1R14Ainteractor31.0000PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
94 PPP2CAsuppressor140.209109.736Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
95 PRKAR1Asuppressor80.42937.661RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
96 RAB1Aoncoprotein70.38172.631Ras (PF00071, IPR001806, SM00173): Ras family
97 RAB5Aoncoprotein70.33341.625Ras (PF00071, IPR001806, SM00173): Ras family
98 RASAL2suppressor50.5005.918C2 (PF00168, IPR000008, SM00239): C2 domain
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
99 RCC1interactor70.5714.679RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
100 RIDAinteractor50.33361.569Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
101 RNASEH2Binteractor100RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
102 RPA1suppressor190.405116.855Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
103 RPA2oncoprotein150.41976.416RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
104 RPA3interactor140.42361.783Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
105 SDCBPinteractor80.39361.689PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
106 SEC13interactor90.6797.626WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
107 SEC16Ainteractor130.46243.825APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
108 SEC23Bprotein found in more fusions70.66717.717Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
109 SERTAD1interactor30.6671.801CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
110 SH3KBP1protein found in more fusions120.32761.693Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
111 SIK2interactor60.4006.789Pkinase (PF00069, IPR000719): Protein kinase domain
112 SMAD3oncoprotein150.209274.734MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
113 SNCAinteractor140.295102.596Synuclein (PF01387, IPR001058): Synuclein
114 SNX22interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
DUF4183 (PF13799, IPR025237): Domain of unknown function (DUF4183)
115 SNX24interactor40.6673.651PX (PF00787, IPR001683, SM00312): PX domain
116 SNX4interactor203.431PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
117 SOCS3suppressor4022.531SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
118 SOD1interactor50.16722.277Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
119 SRPK2oncoprotein100.139212.175DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
120 STAT3suppressor120.30979.155SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
121 STAT5Boncoprotein70.33359.155SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
122 SYT9interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
123 TEX264interactor31.0000NA
124 TIAM1oncoprotein70.38161.374PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
AAA_22 (PF13401, IPR003593): AAA domain
125 TMEM176Ainteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
126 TNFRSF1Boncoprotein200TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
127 TP53suppressor380.207746.444DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
128 UBCprotein found in more fusions290.172524.351ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
129 UNC45Ainteractor90.47215.759Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
130 USP34interactor100Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
131 VCAM1interactor170.294128.130C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
132 XPO1interactor340.153720.964CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
133 XRCC6oncoprotein140.43639.347Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
134 YWHAEoncoprotein170.309123.24714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
135 ZNF618interactor100C1_2 (PF03107, IPR004146): C1 domain
Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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