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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins24 (34.78 %)
The number (and %) of the tumor suppressors3 (4.35 %)
Total number of binary PPIs (saturation %)193 (8.23 %)
The number (and %) of affected PPIs68 (35.23 %)
The number of possible different fusions14
PPI diameter5
PPI radius3
The average degree of PPI4.812
Assortativity coefficient-0.4231
The network average Clustering coefficient0.333
The number (and %) of a zero Clustering coefficients24 (34.78 %)
The number (and %) of a zero Betweenness Centrality22 (31.88 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions HNRNPD (see 1 fusions); RFFL (see 1 fusions); UBE2D2 (see 2 fusions); MALT1 (see 1 fusions); RNF111 (see 1 fusions); UBC (see 1 fusions); STAU1 (see 2 fusions); BAG3 (see 4 fusions); SHFM1/BAG3 (see 1 fusions); RNF168 (see 2 fusions); EGFR (see 2 fusions); UBA1 (see 2 fusions); TRIM29 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2G2parental protein520.0432712.857UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 TAX1BP3parental protein160.050968.892GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
3 ACAA2interactor40.50011.506Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 AMFRoncoprotein80.57120.095CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
5 ARL14interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
6 ARNT2interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
7 AUP1interactor70.42923.011CUE (PF02845, IPR003892, SM00546): CUE domain
8 BAG3oncoprotein50.6672.667BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
9 BIRC8interactor208.583BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 CDK5RAP3interactor30.33344.221DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
11 CNNM3interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
12 CORO1Aoncoprotein100DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
13 CPOXinteractor100Coprogen_oxidas (PF01218, IPR001260): Coproporphyrinogen III oxidase
14 CTNNB1oncoprotein50.10095.728Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
15 DTX1interactor31.0000WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 EGFRoncoprotein70.40054.673Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 ERLEC1interactor100PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
18 FARP2interactor100FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
19 FBXW11interactor130.212180.610WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
20 GATA1oncoprotein21.0000GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
21 HBS1Linteractor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
22 HNRNPABinteractor50.50046.116CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
23 HNRNPDoncoprotein90.39372.728CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 HNRNPDLinteractor40.8331.169CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
25 KDM2Ainteractor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
DZR (PF12773, IPR025874): Double zinc ribbon
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
26 KIAA0368interactor60.33313.095HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
27 MALT1oncoprotein200Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
28 MDM2oncoprotein90.35769.997Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
29 MGRN1interactor30.6678.583zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30 MLLT6oncoprotein100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
31 MUL1interactor50.50014.606DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32 NDUFS4interactor21.0000ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
33 OTUB1interactor70.47632.609Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
34 PARK2suppressor110.244176.881IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
35 PLK4interactor3026.797ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
DUF4520 (PF15016, IPR027865): Domain of unknown function (DUF4520)
36 POLR3Finteractor100RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
37 RBX1oncoprotein40.3339.848zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
38 RC3H1interactor208.583PaaA_PaaC (PF05138, IPR007814): Phenylacetic acid catabolic protein
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
39 RC3H2interactor40.6678.583Xin (PF08043, IPR012510): Xin repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
40 RFFLprotein found in more fusions50.6679.083FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Armet (PF10208, IPR019345): Degradation arginine-rich protein for mis-folding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
41 RNF111suppressor40.6678.583zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
42 RNF139oncoprotein21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
43 RNF146interactor308.583WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
44 RNF157oncoprotein100Peptidase_C70 (PF12385, IPR022118): Papain-like cysteine protease AvrRpt2
TBX (PF12598, IPR022582): T-box transcription factor
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
45 RNF168protein found in more fusions40.6670.969ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
46 RNF183interactor100zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
47 RNF26interactor208.583GtrA (PF04138, IPR007267): GtrA-like protein
Herpes_UL37_1 (PF03970, IPR005655): Herpesvirus UL37 tegument protein
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
48 RNF5interactor60.50066.680zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
49 SHFM1protein found in more fusions60.4678.012CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
50 STAU1protein found in more fusions40.33353.889dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
51 TCEA2interactor100Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
52 TMEM216interactor30.33361.732Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
53 TMEM45Binteractor100DUF716 (PF04819, IPR006904): Family of unknown function (DUF716)
DUF4133 (PF13571, IPR025407): Domain of unknown function (DUF4133)
54 TMEM65interactor21.0000TMEM65 (PF10507, IPR019537): Transmembrane protein 65
55 TOMM40interactor40.16763.114Porin_3 (PF01459, IPR027246): Eukaryotic porin
56 TRIM29protein found in more fusions31.0000MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
57 TRIM3suppressor308.583C1_2 (PF03107, IPR004146): C1 domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
58 TRIM43interactor208.583PaaX_C (PF08223, IPR013225): PaaX-like protein C-terminal domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
59 TRIM9interactor50.6672.367fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Fer4_4 (PF12800, IPR001450): 4Fe-4S binding domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
60 TXNoncoprotein60.33384.512Thioredoxin (PF00085, IPR013766): Thioredoxin
61 UBA1protein found in more fusions60.50021.034ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
62 UBA6interactor30.6678.583ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
63 UBCprotein found in more fusions200.211218.464ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 UBE2D2oncoprotein250.065817.594UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 UBL4Ainteractor80.42939.650ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
66 USP15oncoprotein60.50029.003UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
67 VAMP2interactor40.16779.072Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
68 VAMP8oncoprotein2052.304Synaptobrevin (PF00957, IPR001388): Synaptobrevin
69 ZNRF4interactor208.583PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger

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