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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FXN, CDR2L (from a repository: Wed Aug 28 06:43:27 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins3 (37.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)10 (35.71 %)
The number (and %) of affected PPIs6 (60.00 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.750
Assortativity coefficient0.1667
The network average Clustering coefficient0.271
The number (and %) of a zero Clustering coefficients5 (62.50 %)
The number (and %) of a zero Betweenness Centrality6 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FXN,CDR2L All fusions
Proteins found in more fusions ACTN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FXNparental protein40.16710.000Frataxin_Cyay (PF01491, IPR002908): Frataxin-like domain
2 CDR2Lparental protein202.000ZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
3 ACTN1protein found in more fusions200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 LYRM4interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
6 PICK1oncoprotein100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
7 PMPCBinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
8 RPSAinteractor100Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus

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