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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BAP1, NRG1 (from a repository: Sat Sep 7 18:37:33 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)124
The number (and %) of the onco-proteins23 (18.55 %)
The number (and %) of the tumor suppressors12 (9.68 %)
Total number of binary PPIs (saturation %)280 (3.67 %)
The number (and %) of affected PPIs122 (43.57 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI4.048
Assortativity coefficient-0.4330
The network average Clustering coefficient0.332
The number (and %) of a zero Clustering coefficients59 (47.58 %)
The number (and %) of a zero Betweenness Centrality76 (61.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BAP1,NRG1 All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); UBE2O (see 2 fusions); PTPRJ (see 2 fusions); EGFR (see 2 fusions); ZDHHC17 (see 2 fusions); OPA3 (see 2 fusions); RHOBTB3 (see 1 fusions); HCFC1 (see 2 fusions); UBC (see 7 fusions); MAP3K1 (see 1 fusions); YY1 (see 1 fusions); LIMK1 (see 1 fusions); SREBF2 (see 2 fusions); PSME3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BAP1parental protein580.0545280.005Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
2 NRG1parental protein640.00710194.701EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
3 ABCA3oncoprotein100ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
4 ABCB10oncoprotein100ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
5 ADGRL1interactor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Latrophilin (PF02354, IPR003334): Latrophilin Cytoplasmic C-terminal region
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
6 AHCYL2interactor100AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
7 ANAPC7interactor50.500115.499TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
8 ANKRD17interactor100Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
DUF2536 (PF10750, IPR019686): Protein of unknown function (DUF2536)
KH_1 (PF00013, IPR004088, SM00322): KH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
9 ASXL1suppressor60.6007.467HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
10 ASXL2interactor70.52426.648DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
11 ASXL3interactor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PhaP_Bmeg (PF09602, IPR011728): Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
12 ATP7Binteractor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
13 B3GALNT2interactor100ZapB (PF06005, IPR009252): Cell division protein ZapB
Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
14 B3GNT2interactor30.6671.000Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
15 BAG4interactor21.0000BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
16 BCAR3oncoprotein30.333220.631RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
17 BRCA1suppressor130.288174.358BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
18 C1GALT1C1interactor21.0000NA
19 CASP8suppressor50.8330.667DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
20 CBX1interactor41.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
21 CBX3interactor41.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
22 CDC5Linteractor70.133916.981OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
23 CISD2interactor100zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
24 CNTNAP3interactor100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
25 DDX11L8interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
26 DEGS1interactor100FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Lipid_DES (PF08557, IPR013866): Sphingolipid Delta4-desaturase (DES)
27 DNAAF5interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
28 DSEinteractor100Hepar_II_III (PF07940, IPR012480): Heparinase II/III-like protein
DUF4962 (PF16332, IPR032518): Domain of unknown function (DUF4962)
29 EFNA2interactor100Ephrin (PF00812, IPR001799): Ephrin
30 EGFRoncoprotein190.1113506.792Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
31 EIF4EBP3interactor100eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
32 ELF2interactor21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal
33 ERBB2oncoprotein100.306988.686Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
34 ERBB3oncoprotein60.500314.515Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
35 ERBB4suppressor41.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
36 ESR1suppressor120.273649.791Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
37 EXTL3suppressor100Exostosin (PF03016, IPR004263): Exostosin family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
38 FAM234Binteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
39 FOXK1interactor70.6196.397Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
40 FOXK2interactor100.40069.429FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
41 GALNT11interactor100Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
42 GLMNoncoprotein100Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
43 HAT1interactor50.5005.425Hat1_N (PF10394, IPR019467): Histone acetyl transferase HAT1 N-terminus
Acetyltransf_7 (PF13508, IPR000182): Acetyltransferase (GNAT) domain
Acetyltransf_10 (PF13673, IPR000182): Acetyltransferase (GNAT) domain
44 HCFC1protein found in more fusions110.400565.332fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
45 HIST1H2ABinteractor40.8330.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
46 HIST2H2AA3interactor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
47 HIST2H2ACinteractor90.44451.099Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
48 HLA-DPB1interactor100MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
49 HMOX1interactor200Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
50 HS6ST1interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
51 HSPA1Ainteractor60.400298.692HSP70 (PF00012, IPR013126): Hsp70 protein
52 HSPA2interactor60.467228.205HSP70 (PF00012, IPR013126): Hsp70 protein
53 HSPA9oncoprotein30.66792.394HSP70 (PF00012, IPR013126): Hsp70 protein
54 IGF1Roncoprotein40.667200.489fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
55 INO80interactor40.6671.667Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DBINO (PF13892, IPR020838): DNA-binding domain
FAM176 (PF14851): FAM176 family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
56 INTS7interactor100DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
57 IPO4interactor40.500125.046HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
58 IPO5interactor50.400201.584HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
59 KDM1Binteractor31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
SWIRM (PF04433, IPR007526): SWIRM domain
60 KIAA1107interactor100Acyl-thio_N (PF12590, IPR021113): Acyl-ATP thioesterase
SOBP (PF15279, IPR026092): Sine oculis-binding protein
DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
61 KIAA2013interactor100DUF2152 (PF10222, IPR018795): Uncharacterized conserved protein (DUF2152)
62 KLF5suppressor40.6672.019zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
63 LARGE2interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
Glyco_transf_49 (PF13896): Glycosyl-transferase for dystroglycan
64 LEMD3interactor100LEM (PF03020, IPR003887, SM00540): LEM domain
MSC (PF09402, IPR018996): Man1-Src1p-C-terminal domain
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
65 LIMK1oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
66 LSRinteractor21.0000LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
67 MAP3K1oncoprotein40.6670.667zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
68 MBOAT7interactor100MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
69 MCRS1interactor50.5003.833FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
70 MGAT1interactor100GNT-I (PF03071, IPR004139): GNT-I family
71 MTCH1interactor21.0000YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
72 MYO19interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
73 NBNsuppressor40.500123.952FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
74 NDUFA3interactor100NADHdh_A3 (PF14987, IPR026626): NADH dehydrogenase 1 alpha subcomplex subunit 3
75 NEK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
76 NETO2interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
77 OGTinteractor50.7001.667TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
78 OPA3protein found in more fusions200IL11 (PF07400, IPR020438): Interleukin 11
OPA3 (PF07047, IPR010754): Optic atrophy 3 protein (OPA3)
79 PGAP1interactor100PGAP1 (PF07819, IPR012908): PGAP1-like protein
ChlI (PF13541): Subunit ChlI of Mg-chelatase
80 PIGUinteractor100PIG-U (PF06728, IPR009600): GPI transamidase subunit PIG-U
81 POMGNT2interactor100DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
82 POMT1interactor100MIR (PF02815, IPR016093, SM00472): MIR domain
PMT (PF02366, IPR003342): Dolichyl-phosphate-mannose-protein mannosyltransferase
PMT_4TMC (PF16192, IPR032421): C-terminal four TMM region of protein-O-mannosyltransferase
83 PPM1Ginteractor100Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
84 PRDM10interactor21.0000Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
85 PSME3protein found in more fusions40.66714.982PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
86 PTENsuppressor80.39318.957DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
87 PTPRJsuppressor3092.394fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Syndecan (PF01034, IPR027789): Syndecan domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
88 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
89 RBBP7suppressor90.417286.734WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
90 RDH11interactor200adh_short (PF00106, IPR002198): short chain dehydrogenase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
91 RHOBTB3protein found in more fusions200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
92 RNF130interactor30.333497.530PA (PF02225, IPR003137): PA domain
PspB (PF06667, IPR009554): Phage shock protein B
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
93 SFXN3interactor40.500149.819Mtc (PF03820, IPR004686): Tricarboxylate carrier
94 SLC22A18oncoprotein100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
95 SLC25A16interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
96 SLC25A23interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
97 SLC35B2interactor100UAA (PF08449, IPR013657): UAA transporter family
98 SLC38A10interactor100Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
99 SMSinteractor100Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
100 SPTLC2interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
101 SREBF2protein found in more fusions31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
102 TEPSINinteractor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
103 TM2D3interactor100TM2 (PF05154, IPR007829): TM2 domain
104 TMEM164interactor100TMEM164 (PF14808, IPR026508): TMEM164 family
105 TMEM181interactor100MIG-14_Wnt-bd (PF06664): Wnt-binding factor required for Wnt secretion
DUF4179 (PF13786, IPR025436): Domain of unknown function (DUF4179)
106 TMEM205interactor100PhyH (PF05721, IPR008775): Phytanoyl-CoA dioxygenase (PhyH)
DUF4149 (PF13664, IPR025423): Domain of unknown function (DUF4149)
107 TMEM39Binteractor20493.507Tmp39 (PF10271, IPR019397): Putative transmembrane protein
108 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
109 TMTC3interactor21.0000DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
PMT_2 (PF13231): Dolichyl-phosphate-mannose-protein mannosyltransferase
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
110 TMTC4interactor100DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
111 TRIM63interactor60.8001.686DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
112 TSNAXinteractor100Translin (PF01997, IPR002848): Translin family
113 UBCprotein found in more fusions200.1701787.945ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
114 UBE2Oprotein found in more fusions31.0000BUD22 (PF09073, IPR015158): BUD22
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
115 UQCRQinteractor30.667137.900UcrQ (PF02939, IPR004205): UcrQ family
116 USP15oncoprotein80.57122.015UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
117 USP2interactor90.389546.365UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
118 USP21interactor80.61929.609UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
119 USP28interactor80.52420.690TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
120 XRCC3oncoprotein30.333317.296Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
121 YY1protein found in more fusions50.6678.434zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
122 ZC3H13interactor21.0000FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
123 ZDHHC17protein found in more fusions31.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
124 ZNF131interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PVL_ORF50 (PF07768, IPR011688): PVL ORF-50-like family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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