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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNTTIP2, MELK (from a repository: Thu Jul 18 22:47:47 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins4 (12.90 %)
The number (and %) of the tumor suppressors5 (16.13 %)
Total number of binary PPIs (saturation %)59 (12.69 %)
The number (and %) of affected PPIs30 (50.85 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.161
Assortativity coefficient-0.4908
The network average Clustering coefficient0.336
The number (and %) of a zero Clustering coefficients13 (41.94 %)
The number (and %) of a zero Betweenness Centrality19 (61.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DNTTIP2,MELK All fusions
Proteins found in more fusions KAT5 (see 3 fusions); RXRA (see 2 fusions); MELK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DNTTIP2parental protein180.092480.848BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
E7 (PF00527, IPR000148): E7 protein, Early protein
Fcf2 (PF08698, IPR014810): Fcf2 pre-rRNA processing
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
2 MELKparental protein120.018410.667KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
3 BABAM1interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
4 CBWD1interactor100cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
5 CDC25Boncoprotein30.33398.243M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
6 CDC5Linteractor50.333128.495OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
7 DNTTinteractor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
8 ESR1suppressor60.400113.643Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
9 ESR2suppressor41.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
10 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
11 HIST1H2BAinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST2H3Ainteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST3H2Ainteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
14 HIST4H4interactor30.6671.900CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
15 HNRNPA1interactor60.400102.152RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
16 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
17 KAT5suppressor70.40017.667MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
18 LMNB1interactor30.333122.829Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
19 MBPinteractor100Myelin_MBP (PF01669, IPR000548): Myelin basic protein
20 MLST8interactor100Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
21 NIFKinteractor40.50015.952RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
22 OBSL1interactor80.286184.605BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
23 PHF8interactor100JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
24 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
25 PPARGsuppressor40.6671.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
26 PRG2interactor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
27 RXRAoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
28 SIRT7interactor21.0000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
29 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
30 SPP1oncoprotein100Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
31 ZNF622interactor200S-antigen (PF05756, IPR008825): S-antigen protein
Stm1_N (PF09598, IPR019084): Stm1
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)

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