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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)74
The number (and %) of the onco-proteins26 (35.14 %)
The number (and %) of the tumor suppressors11 (14.86 %)
Total number of binary PPIs (saturation %)309 (11.44 %)
The number (and %) of affected PPIs72 (23.30 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI7.405
Assortativity coefficient-0.2497
The network average Clustering coefficient0.559
The number (and %) of a zero Clustering coefficients7 (9.46 %)
The number (and %) of a zero Betweenness Centrality22 (29.73 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions HSPB1/OBSL1 (see 1 fusions); KIF11 (see 1 fusions); SMAD4 (see 2 fusions); PRKDC (see 3 fusions); TOPBP1 (see 2 fusions); VCP (see 4 fusions); HSPB1 (see 4 fusions); CSNK2A1 (see 1 fusions); COPS5 (see 1 fusions); SUV39H1 (see 1 fusions); VPS26A (see 1 fusions); KCMF1 (see 3 fusions); VPS35 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MACROD2parental protein21.0000Macro (PF01661, IPR002589, SM00506): Macro domain
Silic_transp (PF03842, IPR004693): Silicon transporter
SUZ (PF12752, IPR024771): SUZ domain
TEX19 (PF15553, IPR029093): Testis-expressed protein 19
2 HDLBPparental protein700.0813733.365BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
3 ACTL6Ainteractor40.6671.667Actin (PF00022, IPR004000, SM00268): Actin
4 ADARinteractor60.6002.265dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
5 AKTIPinteractor30.33364.427UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
6 ARRB1interactor40.8330.375Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATP6V1B2interactor30.6670.250ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
8 BPGMinteractor100Exc (PF07825, IPR012884): Excisionase-like protein
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
9 CBX5suppressor60.4005.667Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
10 CCDC8interactor100.47214.363Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
11 CDC5Linteractor160.42939.068OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12 CDK2suppressor160.41947.390Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
13 CLUHinteractor40.6671.222DUF727 (PF05303, IPR007967): Protein of unknown function (DUF727)
eIF3_p135 (PF12807): Translation initiation factor eIF3 subunit 135
CLU (PF13236, IPR025697): Clustered mitochondria
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
CLU_N (PF15044, IPR028275): Mitochondrial function, CLU-N-term
14 COPS5protein found in more fusions170.37560.709JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CSNK2A1oncoprotein110.53311.684Pkinase (PF00069, IPR000719): Protein kinase domain
16 CYP1A1oncoprotein21.0000p450 (PF00067, IPR001128): Cytochrome P450
17 DDX43oncoprotein100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
18 DHX9oncoprotein150.46730.088DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
20 EIF2Ainteractor50.5004.667Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
21 ERBB2oncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 ESR1suppressor170.30873.291Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
23 FAM46Ainteractor21.0000NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
24 FAUinteractor30.6671.000Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 GLMNoncoprotein21.0000Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
26 HSPB1oncoprotein130.42426.880HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
27 IKBKGinteractor60.4003.917CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
28 KCMF1oncoprotein70.4008.002zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
Ntox28 (PF15605, IPR028948): Bacterial toxin 28
29 KIF11protein found in more fusions60.7003.000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
30 LGR4interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
31 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
32 MLH1suppressor50.8001.848DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
33 NTRK1oncoprotein310.191318.089I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 OBSL1protein found in more fusions140.43628.495BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
35 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
36 PRKDCprotein found in more fusions190.412135.458FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
37 PSMD12interactor60.6002.233Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
38 PTCRAoncoprotein21.0000PTCRA (PF15028, IPR027834): Pre-T-cell antigen receptor
39 S100A10oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 S100A11suppressor200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
41 SAC3D1interactor51.0000SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
42 SCARNA22interactor60.7332.394NA
43 SERPINB3oncoprotein30.6670.333Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
44 SERPINB5suppressor60.3338.500Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
45 SIRT7interactor100.33324.099DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
46 SMAD4suppressor50.5001.917MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
47 SMSinteractor31.0000Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
48 SNW1protein found in more fusions160.35245.623SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
49 SOS1oncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
50 SUV39H1protein found in more fusions50.5003.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
51 TERF1interactor60.40074.979TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
52 TERF2interactor60.30076.411Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
53 TMEM171interactor21.0000TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
54 TOPBP1protein found in more fusions31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
55 TTC4suppressor90.63910.138TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
56 TTKinteractor80.7142.217Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
57 TYRO3oncoprotein30.6670.667fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
58 UBA6interactor70.4299.250ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
59 UBE2Ainteractor50.5002.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
60 UBE4Bsuppressor120.52720.088DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
61 UPF1interactor110.45515.575UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
62 VCPprotein found in more fusions160.295134.932AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
63 VPS25interactor61.0000ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
64 VPS26Aprotein found in more fusions100.7224.667Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
65 VPS29interactor80.8212.100Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
66 VPS35protein found in more fusions120.58213.567FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
67 VPS36interactor90.7145.200EAP30 (PF04157, IPR007286): EAP30/Vps36 family
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
68 WWOXsuppressor90.27819.841adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
69 XPOTinteractor40.5002.222DUF310 (PF03750, IPR010149): Protein of unknown function (DUF310)
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
70 XRCC5suppressor160.371166.194Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
71 YBX1oncoprotein90.5836.168CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
72 ZCCHC7interactor100zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
zf-CCHC_3 (PF13917): Zinc knuckle
73 ZNF598interactor30.6670.333Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
74 ZW10interactor21.0000Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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