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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NPTN, HBB (from a repository: Thu Aug 22 05:50:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins8 (17.39 %)
The number (and %) of the tumor suppressors3 (6.52 %)
Total number of binary PPIs (saturation %)104 (10.05 %)
The number (and %) of affected PPIs44 (42.31 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.870
Assortativity coefficient-0.3932
The network average Clustering coefficient0.345
The number (and %) of a zero Clustering coefficients21 (45.65 %)
The number (and %) of a zero Betweenness Centrality27 (58.70 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NPTN,HBB All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); NPTN/NDUFV2 (see 1 fusions); SMG6 (see 1 fusions); LGALS3 (see 2 fusions); MCM2 (see 1 fusions); PABPC1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NPTNparental protein80.071352.927C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 HBBparental protein360.0561488.729Globin (PF00042, IPR000971): Globin
3 AGAinteractor3034.963Asparaginase_2 (PF01112, IPR000246): Asparaginase
4 AKT1oncoprotein31.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 CDK2suppressor50.6672.400Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CEP250interactor30.6670.952ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
7 COPS3interactor2034.963RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
8 CYTIPinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
G6B (PF15096, IPR028070): G6B family
9 DACH1suppressor200DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508)
Pap_E4 (PF02711, IPR003861): E4 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 DHRS2interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
11 DMWDinteractor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12 EIF4A3interactor80.429155.379DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 ERBB3oncoprotein50.33384.823Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 FAM189Binteractor100CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
15 FBXO6interactor60.133213.265FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 GDAP1interactor100SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
DUF4296 (PF14129, IPR025381): Domain of unknown function (DUF4296)
17 GDPD1interactor21.0000GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
18 HBA1interactor50.4009.016Globin (PF00042, IPR000971): Globin
19 HPinteractor21.0000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
20 JOSD2interactor100Josephin (PF02099, IPR006155): Josephin
21 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
22 MCM2oncoprotein70.200173.310AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
23 MED4interactor100Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
24 MGAT4Binteractor100Glyco_transf_54 (PF04666, IPR006759): N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
25 NDUFAF5interactor200Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
26 NDUFV2protein found in more fusions1002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
27 NIT2suppressor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
28 PABPC1oncoprotein90.321107.805RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
29 PAN2interactor30.6670.952RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
30 PDLIM7interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
31 PGPEP1interactor100Peptidase_C15 (PF01470, IPR000816): Pyroglutamyl peptidase
32 PNPLA1interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
33 RBM8Ainteractor100.61117.522RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 SELENOTinteractor100Rdx (PF10262, IPR011893): Rdx family
35 SLC25A5interactor60.200221.053Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
36 SMG6oncoprotein70.8002.389EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
PIN_4 (PF13638, IPR002716): PIN domain
37 SMG7interactor41.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
38 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
39 TMEM92interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
40 UBXN1interactor3036.778Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
41 UCHL5oncoprotein31.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
42 UPF1interactor100.53323.522UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
43 UPF2interactor61.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
44 UPF3Ainteractor51.0000Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
45 UPF3Binteractor70.7627.250HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
46 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain

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