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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)235
The number (and %) of the onco-proteins72 (30.64 %)
The number (and %) of the tumor suppressors27 (11.49 %)
Total number of binary PPIs (saturation %)1170 (4.26 %)
The number (and %) of affected PPIs240 (20.51 %)
The number of possible different fusions51
PPI diameter4
PPI radius2
The average degree of PPI9.004
Assortativity coefficient-0.3413
The network average Clustering coefficient0.342
The number (and %) of a zero Clustering coefficients43 (18.30 %)
The number (and %) of a zero Betweenness Centrality53 (22.55 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SIAH1,ANXA1 All fusions
Proteins found in more fusions AFF1 (see 2 fusions); USP25 (see 1 fusions); U2AF2 (see 2 fusions); HIPK2 (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); BCL6 (see 2 fusions); UBE2N (see 1 fusions); PIAS2 (see 2 fusions); RUNX1 (see 1 fusions); UBE2D2 (see 2 fusions); KIF11 (see 1 fusions); CCDC88A (see 3 fusions); SH3RF1 (see 1 fusions); UBE2E2 (see 1 fusions); HIF1AN (see 1 fusions); PIAS1 (see 2 fusions); SNCAIP (see 1 fusions); RARA (see 4 fusions); APC (see 1 fusions); HTT (see 1 fusions); COPS5 (see 1 fusions); PYGB (see 1 fusions); MAP3K5 (see 1 fusions); RPA1 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); RARA/PML (see 21 fusions); PUF60 (see 2 fusions); PKD1 (see 1 fusions); SIAH1 (see 4 fusions); RBBP8 (see 1 fusions); FAF1 (see 2 fusions); EEF1D (see 3 fusions); ENO1/CCT7 (see 1 fusions); STAT3 (see 2 fusions); UBE2L6 (see 2 fusions); RARA/NPM1 (see 1 fusions); BAG3 (see 4 fusions); RIPK1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); HSPB1 (see 4 fusions); SIAH2 (see 1 fusions); ATN1 (see 1 fusions); PFKM (see 1 fusions); PML (see 4 fusions); TBL1X (see 2 fusions); MEIS2 (see 1 fusions); PSMC5 (see 2 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SIAH1parental protein1580.02530973.384Sina (PF03145, IPR018121): Seven in absentia protein family
2 ANXA1parental protein820.07310189.543Annexin (PF00191, IPR018502, SM00335): Annexin
3 AASDHPPTinteractor50.30048.865ACPS (PF01648, IPR008278): 4'-phosphopantetheinyl transferase superfamily
4 AFF1oncoprotein70.40037.547AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5 AFF4oncoprotein40.50038.926AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
6 ANXA4interactor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
7 ANXA5oncoprotein80.42918.975Annexin (PF00191, IPR018502, SM00335): Annexin
8 APBB1interactor40.6671.567PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
9 APCsuppressor90.286249.376APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
10 AQP1interactor40.6671.182MIP (PF00230, IPR000425): Major intrinsic protein
11 ARMC9interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
12 ATF2oncoprotein140.167178.383bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
13 ATG4Binteractor40.6671.402Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
14 ATN1protein found in more fusions70.26758.328Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
15 ATP4Ainteractor200Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
16 ATXN7interactor100.35666.114DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
17 BAG1oncoprotein80.25099.674BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
18 BAG3oncoprotein190.144355.562BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
19 BCL6oncoprotein80.286129.095BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
20 C14orf1interactor40.5002.816Erg28 (PF03694, IPR005352): Erg28 like protein
21 C14orf105interactor21.0000DUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)
22 C1orf123interactor100DUF866 (PF05907, IPR008584): Eukaryotic protein of unknown function (DUF866)
23 CACYBPinteractor90.28678.811CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
24 CAPGsuppressor40311.018Gelsolin (PF00626, IPR007123): Gelsolin repeat
25 CCDC88Aprotein found in more fusions4046.512bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
26 CCT7protein found in more fusions120.37933.356Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
27 CD4suppressor70.6009.665ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
28 CDC23interactor60.10083.052ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
29 CDC34oncoprotein50.50013.293UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30 CDK2suppressor340.178844.326Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
31 CDK5R1oncoprotein30.6679.438CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
32 CEP128interactor80.46447.508DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
33 CEP152interactor40.5003.836bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
34 CEP89interactor40.8339.305ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
35 COPS5protein found in more fusions290.201994.435JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
36 COPS6interactor110.46756.032DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
37 CSADinteractor21.0000GLE1 (PF07817, IPR012476): GLE1-like protein
Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
38 CTNNB1oncoprotein240.152656.167Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
39 CUL5suppressor160.333173.301Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
40 CUL7protein found in more fusions240.257187.916ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
41 DAB1interactor50.6003.667PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
42 DCCsuppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
43 DCTN1interactor80.190127.798Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
44 DDX19Binteractor50.20049.767DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
45 DDX41interactor40.16751.048DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
zf-CCHC (PF00098, IPR001878): Zinc knuckle
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
46 DLDinteractor50.20072.960Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
47 DLG3interactor30.33314.455PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
48 DNAJC15interactor200DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3918 (PF13056, IPR025029): Protein of unknown function (DUF3918)
49 DNALI1interactor31.0000Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
50 EEF1Dprotein found in more fusions170.275268.992EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
51 EGFRoncoprotein220.133547.271Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
52 ELL2interactor31.0000Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
53 ENO1oncoprotein240.366245.106Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
54 EXOC3-AS1interactor21.0000NA
55 FAF1protein found in more fusions50.16710.317UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
56 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
57 FLI1oncoprotein41.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
58 FLT3suppressor40.33328.738I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
59 FN1oncoprotein280.225511.010fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
60 FZD9interactor100Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region
Fz (PF01392, IPR020067, SM00063): Fz domain
61 GAPDHoncoprotein260.317845.986Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
62 GDPD5interactor100DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
MgtE (PF01769, IPR006667): Divalent cation transporter
GDPD_2 (PF13653): Glycerophosphoryl diester phosphodiesterase family
63 GOLT1Binteractor2060.930Got1 (PF04178, IPR007305): Got1/Sft2-like family
64 GRM5interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
65 HECW2interactor100.111245.556C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
66 HERPUD1oncoprotein70.23868.441Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
67 HIF1ANprotein found in more fusions4031.525Cupin_8 (PF13621): Cupin-like domain
68 HIPK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
69 HIPK2suppressor70.66721.715Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
70 HIPK3interactor40.6679.956Pkinase (PF00069, IPR000719): Protein kinase domain
71 HIST4H4interactor90.222123.474CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
72 HMGA1oncoprotein130.38557.357AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
73 HNRNPA1interactor350.278608.366RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
74 HSPB1oncoprotein240.245282.238HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
75 HTTprotein found in more fusions150.198232.318HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
76 IKBKGinteractor170.133497.565CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
77 INHAoncoprotein2025.337TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
78 ITGA4interactor190.425139.304FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
79 JSRP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
80 KATNAL1interactor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_24 (PF13479): AAA domain
81 KCNJ10interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
82 KHDRBS3interactor40.33321.312KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
83 KIAA0319Linteractor100EGF_2 (PF07974, IPR013111): EGF-like domain
PKD (PF00801, IPR000601, SM00089): PKD domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
DUF4625 (PF15418, IPR027829): Domain of unknown function (DUF4625)
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
84 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
85 KIAA1683interactor30.6670.653IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
86 KIF11protein found in more fusions50.16716.046Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
87 KIF1Bsuppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
DUF3694 (PF12473, IPR022164): Kinesin protein
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
88 KIF22interactor40.16751.048Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
89 KIFC3oncoprotein70.33341.263Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
90 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
91 KLF10suppressor30.33311.898zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
AAA_33 (PF13671): AAA domain
92 KLHL23interactor203.460BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
93 KMT2Boncoprotein3044.707FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
GRP (PF07172, IPR010800): Glycine rich protein family
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
94 KRT8interactor70.42912.128Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
95 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
96 LATS2suppressor130.227435.340Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
97 LRIF1interactor50.16729.258LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
98 MAB21L1interactor20157.203Mab-21 (PF03281, IPR024810): Mab-21 protein
99 MAP1Sinteractor40.5007.508Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
100 MAP3K5oncoprotein60.50029.638Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
101 MAPK12oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
102 MAPKBP1interactor21.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
103 MAPRE3interactor30.33389.816CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
104 MCM2oncoprotein360.2451460.635AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
105 MEIS2protein found in more fusions40.33363.295Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
106 MGMTinteractor50.60031.232DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
107 MOB3Cinteractor21.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
108 MOV10interactor250.113760.378AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
109 MTIF3interactor100IF3_C (PF00707, IPR019815): Translation initiation factor IF-3, C-terminal domain
IF3_N (PF05198, IPR019814): Translation initiation factor IF-3, N-terminal domain
110 MX1interactor60.40022.815Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
111 MYD88oncoprotein60.30041.640Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
112 NECTIN2interactor200C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
113 NELFAinteractor3043.620CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
114 NOL6interactor80.42985.511Nrap (PF03813, IPR005554): Nrap protein
115 NPM1suppressor370.2061269.664Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
116 NSL1interactor100Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
117 NUMBsuppressor30.33315.633NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
118 NUMBLinteractor30.33364.898DUF1932 (PF09130, IPR015814): Domain of unknown function (DUF1932)
NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
119 NXF1interactor300.118812.095NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
120 OBSL1protein found in more fusions220.333198.708BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
121 OPRD1interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
122 OPRK1interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
123 OPRM1interactor40.6676.7077tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
124 OTUB1interactor130.154252.312Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
125 OTUB2interactor50.5006.858Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
126 PARD3interactor60.400203.297PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
127 PEG10oncoprotein60.33314.392CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
128 PEG3suppressor40.33310.197C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_10 (PF13237, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-Mss51 (PF13824, IPR032717): Zinc-finger of mitochondrial splicing suppressor 51
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
129 PFKMprotein found in more fusions70167.915PFK (PF00365, IPR000023): Phosphofructokinase
130 PHC1interactor60.6004.860GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
FSA_C (PF10479, IPR018863): Fragile site-associated protein C-terminus
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
131 PHC2interactor110.200128.879SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
132 PIAS1suppressor150.363110.112Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
133 PIAS2protein found in more fusions110.55633.677SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
134 PIAS3oncoprotein80.35744.585SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
135 PKD1suppressor40.33312.110Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
136 PLCE1suppressor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
137 PMLsuppressor220.252324.864zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
138 POU2AF1oncoprotein100PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1
139 PPIAinteractor130.56429.459Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
140 PPM1Binteractor31.0000PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
141 PRPF31interactor110.178126.223Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
142 PRR20Ainteractor41.0000PRR20 (PF15708, IPR031439): Proline-rich protein family 20
143 PSMC5protein found in more fusions140.205200.381AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
144 PSMC6interactor80.33372.110AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
145 PTPMT1interactor40.6670.725DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
146 PUF60protein found in more fusions170.258363.233RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
147 PYGBprotein found in more fusions50.66724.481Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
148 QRICH1interactor60.20062.762CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
149 RAB33Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
150 RAD51AP1interactor100RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
151 RAD54L2interactor50.60020.178SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
152 RAPH1oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
FAM76 (PF16046, IPR032017): FAM76 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
153 RARAoncoprotein140.192303.237zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
154 RASSF10suppressor30.66718.675DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
155 RBBP8suppressor50.33339.354ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
156 RELAoncoprotein190.131381.190DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
157 RIPK1protein found in more fusions70.33367.847Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
158 RLIMinteractor80.3338.638DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
159 RNF2interactor310.149775.440zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
160 RPA1suppressor160.44855.872Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
161 RPL27Ainteractor130.385204.699Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
162 RPS19BP1interactor21.0000AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
163 RUNX1suppressor80.33353.139Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
164 S100A11suppressor70.4676.573S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
165 SDCBPinteractor100.178117.203PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
166 SEPT4suppressor30.6671.000Septin (PF00735, IPR000038): Septin
167 SH3RF1protein found in more fusions70.4676.437zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
168 SIAH2oncoprotein350.100769.676Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
169 SIRT7interactor140.319125.576DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
170 SLX1Binteractor100GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
171 SNCAinteractor100.333136.516Synuclein (PF01387, IPR001058): Synuclein
172 SNCAIPprotein found in more fusions50.8330.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
173 SOX2oncoprotein120.109199.662HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
174 SPATA4interactor100CH_2 (PF06294, IPR010441): CH-like domain in sperm protein
175 SPATC1Linteractor30.6670.433Speriolin_N (PF15058, IPR029385): Speriolin N terminus
Speriolin_C (PF15059, IPR029384): Speriolin C-terminus
176 STAT3suppressor110.267176.395SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
177 STK4oncoprotein50.33324.254Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
178 SUMO2interactor190.170426.609Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
179 SYPinteractor100MARVEL (PF01284, IPR008253): Membrane-associating domain
180 SYT7interactor2023.352C2 (PF00168, IPR000008, SM00239): C2 domain
SCIMP (PF15050, IPR028181): SCIMP protein
181 TBC1D22Binteractor40.6672.388RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
182 TBL1Xprotein found in more fusions90.39330.951K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
183 TERF2interactor120.200294.603Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
184 TFDP1oncoprotein40.33312.144DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
185 TFGoncoprotein80.38123.063ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
186 TMEM43interactor20167.396TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
187 TNK2interactor70.133117.755CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
188 TOLLIPinteractor90.35719.880C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
189 TP53BP2suppressor160.175932.735ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
190 TRIB3interactor50.10060.180Pkinase (PF00069, IPR000719): Protein kinase domain
191 TRIM23interactor170.233193.464Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
192 TRIM27oncoprotein370.108924.133IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
193 TRIM7oncoprotein50.6670.297IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
YojJ (PF10372, IPR019457): Bacterial membrane-spanning protein N-terminus
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
194 TRIM8interactor110.33328.861dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
195 TXNoncoprotein150.305224.927Thioredoxin (PF00085, IPR013766): Thioredoxin
196 U2AF2protein found in more fusions190.353248.117RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
197 UBE2D1interactor190.261592.015UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
198 UBE2D2oncoprotein190.281153.397UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
199 UBE2D3interactor170.192196.202UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
200 UBE2D4interactor90.32128.222UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
201 UBE2E2protein found in more fusions80.38121.633UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
202 UBE2E3interactor70.40022.444UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
203 UBE2Iinteractor370.1491861.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
204 UBE2Kinteractor110.38279.370UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
205 UBE2L6protein found in more fusions100.25051.274UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
206 UBE2Nprotein found in more fusions160.171346.226UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
207 UBE2V2interactor70.286136.666UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
208 UBE3Aoncoprotein120.145143.463HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
209 UCHL5oncoprotein100.111161.956Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
210 UCP2interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
211 UGT1A10interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
212 UNC119interactor40.5007.467GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
213 UPP2interactor200PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
214 USP19interactor70.238105.403CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
215 USP25protein found in more fusions50.6671.172UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UBA_4 (PF14555): UBA-like domain
216 USP7oncoprotein220.143528.300MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
217 USPL1interactor40.5002.644zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase
DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
218 UXTinteractor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
219 VAV1oncoprotein40.16736.436PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
220 VCAM1interactor180.346156.583C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
221 WDYHV1interactor60.46710.269Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
222 WWOXsuppressor80.14393.432adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
223 XIAPinteractor180.184243.504BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
224 XRCC6oncoprotein270.255424.699Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
225 YWHAQinteractor190.333294.70114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
226 ZBP1interactor100z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
227 ZBTB1interactor50.5009.429BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
228 ZCCHC10interactor30.6671.491Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
229 ZCCHC13interactor100DUF1815 (PF08844, IPR014943): Domain of unknown function (DUF1815)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
230 ZFYVE21interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
ZFYVE21_C (PF16696, IPR032031): Zinc finger FYVE domain-containing protein 21 C-terminus
231 ZMAT3interactor2015.430zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
232 ZNF148interactor100DUF680 (PF05079, IPR007771): Protein of unknown function (DUF680)
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
233 ZNF512Binteractor60.133221.822YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
234 ZNF671interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
235 ZSCAN20interactor30.33330.216SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Glyco_trans_1_2 (PF13524): Glycosyl transferases group 1
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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