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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)243
The number (and %) of the onco-proteins69 (28.40 %)
The number (and %) of the tumor suppressors32 (13.17 %)
Total number of binary PPIs (saturation %)2060 (7.01 %)
The number (and %) of affected PPIs244 (11.84 %)
The number of possible different fusions50
PPI diameter4
PPI radius2
The average degree of PPI16.189
Assortativity coefficient-0.2522
The network average Clustering coefficient0.372
The number (and %) of a zero Clustering coefficients26 (10.70 %)
The number (and %) of a zero Betweenness Centrality40 (16.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HIST1H1C,UBE3A All fusions
Proteins found in more fusions UBE3A/YWHAZ (see 1 fusions); CEBPA (see 1 fusions); NPM1 (see 1 fusions); DCAF1 (see 1 fusions); HSF1 (see 3 fusions); CUL1 (see 3 fusions); RNF168 (see 2 fusions); PARK2 (see 1 fusions); VHL (see 1 fusions); UBQLN1 (see 2 fusions); EIF2AK2 (see 1 fusions); PRKDC (see 2 fusions); PRDX1 (see 1 fusions); HIF1AN (see 1 fusions); YWHAZ (see 5 fusions); HDAC5 (see 1 fusions); UBE2E1 (see 1 fusions); SUZ12 (see 2 fusions); APP (see 5 fusions); CUL4A (see 4 fusions); GFAP (see 3 fusions); APEH (see 1 fusions); HSP90AB1 (see 3 fusions); CALR (see 8 fusions); UBE2L6 (see 2 fusions); POLR2A (see 2 fusions); DDB1 (see 4 fusions); PML (see 4 fusions); NCL (see 4 fusions); CUL3 (see 1 fusions); PSAP (see 6 fusions); UBE3A (see 1 fusions); UBE2D2 (see 1 fusions); ACTB (see 7 fusions); RARA (see 1 fusions); COPS5 (see 1 fusions); PARP1 (see 1 fusions); UBC (see 7 fusions); TP53 (see 3 fusions); RARA/PML (see 21 fusions); MCM7 (see 2 fusions); PUF60 (see 1 fusions); SFN (see 1 fusions); KPNB1 (see 2 fusions); LCK (see 1 fusions); RARA/NPM1 (see 1 fusions); MCM2 (see 1 fusions); UBQLN2 (see 3 fusions); TRIM29 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HIST1H1Cparental protein830.1294740.357Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
2 UBE3Aparental protein1610.04525195.252HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
3 ABCE1interactor150.27572.757ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ACTA1interactor90.44426.485Actin (PF00022, IPR004000, SM00268): Actin
5 ACTA2interactor160.40871.808Actin (PF00022, IPR004000, SM00268): Actin
6 ACTBoncoprotein320.226462.168Actin (PF00022, IPR004000, SM00268): Actin
7 ACTBL2interactor160.342103.651Actin (PF00022, IPR004000, SM00268): Actin
8 ACTR3interactor90.47223.250Actin (PF00022, IPR004000, SM00268): Actin
9 ADRM1interactor160.79212.253Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
10 AEBP2interactor40.5002.743Bindin (PF02084, IPR000775): Bindin
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764)
11 AFG3L1Pinteractor21.0000NA
12 AFTPHinteractor21.0000Clathrin_bdg (PF15045, IPR029205): Clathrin-binding box of Aftiphilin, vesicle trafficking
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
13 AHSPinteractor100AHSP (PF09236, IPR015317): Alpha-haemoglobin stabilising protein
14 ANXA1suppressor90.32117.949Annexin (PF00191, IPR018502, SM00335): Annexin
15 ANXA2interactor180.327180.977Annexin (PF00191, IPR018502, SM00335): Annexin
16 APEHoncoprotein70.53336.404Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
17 APPprotein found in more fusions460.1411554.142APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
18 ARoncoprotein230.255200.009Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 ARCinteractor100DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
20 ARHGDIBinteractor21.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
21 ARHGEF15interactor21.0000Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
22 ARNTLsuppressor30.3337.090HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
23 ARNTL2interactor201.787HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
24 ARPC1Binteractor110.43660.765WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25 ARRB1interactor190.40945.539Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
26 ARRB2interactor260.326163.055Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
27 ASAP3interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
BAR_3 (PF16746): BAR domain of APPL family
28 ASB16interactor30.33316.938Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
29 ASB9interactor80.10736.083Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
30 ASPMoncoprotein40.5002.459CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
31 ASXL1suppressor50.10014.233HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain
ASXH (PF13919, IPR028020): Asx homology domain
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
32 ATG9Ainteractor50.5004.464APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
33 ATRXoncoprotein90.36121.529DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
34 BARD1suppressor270.203286.324BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
35 BLKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
36 BPY2interactor100NA
37 BRCA1suppressor340.220427.776BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
38 BTF3L4interactor41.0000NAC (PF01849, IPR002715): NAC domain
39 C11orf49interactor21.0000NA
40 CALM1interactor230.273159.590EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
41 CALM2interactor50.3009.933EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
42 CALRoncoprotein150.36362.704Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
43 CAND1interactor500.286475.443Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
44 CD81interactor120.41820.460Tetraspannin (PF00335, IPR018499): Tetraspanin family
45 CDC73suppressor110.52721.470CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
46 CDKN1Bsuppressor130.50043.615CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
47 CEBPAsuppressor120.273108.212Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
48 CEBPZinteractor60.46710.904BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
49 CELA2Binteractor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
50 CENPAinteractor140.32188.865Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
51 CEP250interactor210.157174.813ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
52 CFTRsuppressor110.33351.827ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
53 COPS5protein found in more fusions540.301519.053JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
54 CSNK2A2interactor100.48947.891Pkinase (PF00069, IPR000719): Protein kinase domain
55 CTNNB1oncoprotein260.271222.612Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
56 CTR9interactor100.57820.943DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
57 CUL1suppressor540.262528.991Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
58 CUL2suppressor380.334186.767Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
59 CUL3protein found in more fusions680.2101169.314Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
60 CUL4Aprotein found in more fusions340.426136.246Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
61 CUL4Boncoprotein350.392201.088Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
62 CUL5suppressor400.351377.056Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
63 DAXXoncoprotein150.27587.623Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
64 DBNLinteractor100.31173.966RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
65 DCAF1protein found in more fusions180.58126.536DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
66 DDB1protein found in more fusions300.355135.375CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
67 DDX39Binteractor110.20087.967DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
68 DLG1suppressor40.3337.392L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
69 DOT1Loncoprotein40.6672.384AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DivIC (PF04977, IPR007060): Septum formation initiator
DOT1 (PF08123, IPR013110): Histone methylation protein DOT1
ZapB (PF06005, IPR009252): Cell division protein ZapB
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
70 DR1interactor110.34544.806CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
71 EAPPinteractor100Serglycin (PF04360, IPR007455): Serglycin
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
72 EEDsuppressor330.232256.578WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
73 EID1interactor50.50025.570NA
74 EIF2AK2oncoprotein120.49133.934dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
75 EIF4G1oncoprotein120.31828.342DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
76 ESR1suppressor450.241626.053Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
77 ESR2suppressor110.46735.155zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
78 FAF2interactor220.310169.467DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
79 FIP1L1oncoprotein80.4297.174Fip1 (PF05182, IPR007854): Fip1 motif
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM176 (PF14851): FAM176 family
Auts2 (PF15336): Autism susceptibility gene 2 protein
80 GFAPprotein found in more fusions60.40011.950Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
81 GOLGA3interactor60.20016.602ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
G-gamma (PF00631, IPR015898, SM00224): GGL domain
SOGA (PF11365, IPR027881): Protein SOGA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
82 GTF3C1interactor60.53314.854B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
83 H1FXinteractor170.30193.392IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
84 HBA1interactor50.10024.084Globin (PF00042, IPR000971): Globin
85 HDAC5protein found in more fusions310.308125.660Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
86 HDGFinteractor180.29460.830PWWP (PF00855, IPR000313, SM00293): PWWP domain
87 HERC2interactor210.232181.387ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
88 HIF1ANprotein found in more fusions50144.865Cupin_8 (PF13621): Cupin-like domain
89 HIST1H2ADinteractor50.5003.507Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
90 HIST1H3Ainteractor290.238273.466Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
91 HIST1H3Einteractor200.35372.726Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
92 HPCAL4interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
93 HSF1protein found in more fusions130.31884.255DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
94 HSP90AB1oncoprotein360.370296.822HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
95 HSPA4interactor290.333290.818Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
96 HSPA5oncoprotein460.296695.069HSP70 (PF00012, IPR013126): Hsp70 protein
97 HSPA8oncoprotein460.300504.596HSP70 (PF00012, IPR013126): Hsp70 protein
98 ICAM1oncoprotein70.4293.311Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
99 IGSF8oncoprotein100.5117.590V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
100 IL7Rinteractor90.25013.691fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
101 IPO11interactor90.38928.251DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
102 IRAK4interactor100Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
103 ITGA4interactor380.179385.332FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
104 JADE1interactor40.16712.867C1_2 (PF03107, IPR004146): C1 domain
Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
105 KLHL38interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
106 KPNA7interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
107 KPNB1protein found in more fusions230.42056.925Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
108 KRT1interactor200.374112.141Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
109 KRT5interactor120.57636.644Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
110 KRT6Binteractor90.36125.320Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
111 KRT7interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
112 KRT9interactor150.48654.429Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
113 LCKoncoprotein60.4007.654Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
114 LEO1interactor110.54522.151Leo1 (PF04004, IPR007149): Leo1-like protein
PPP4R2 (PF09184, IPR015267): PPP4R2
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
115 LPPoncoprotein110.27347.152LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
116 LRSAM1interactor110.28935.696Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
117 LSM1interactor21.0000LSM (PF01423, IPR001163): LSM domain
118 LSM5interactor100LSM (PF01423, IPR001163): LSM domain
119 MAGEA1interactor40.33310.850MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
120 MAGEA8interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
121 MAPK6oncoprotein90.32116.955Pkinase (PF00069, IPR000719): Protein kinase domain
122 MCM2oncoprotein610.1621248.134AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
123 MCM5oncoprotein300.262252.141MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
124 MCM7protein found in more fusions230.268179.516MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
125 MDM1interactor100MDM1 (PF15501, IPR029136): Nuclear protein MDM1
126 MDM2oncoprotein440.256472.182Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
127 MEOX2interactor70.38118.401Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
128 METTL1interactor80.42916.041Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
129 MNTsuppressor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Sipho_Gp157 (PF05565, IPR008840): Siphovirus Gp157
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
130 MYCBP2interactor70.52415.788ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHR (PF08005, IPR012983): PHR domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SH3_3 (PF08239, IPR003646): Bacterial SH3 domain
XPA_N (PF01286, IPR022652): XPA protein N-terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
131 MYH9suppressor300.276328.348IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
132 NCLprotein found in more fusions400.321315.358DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
133 NCOA3oncoprotein140.38538.506DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
134 NDUFA13interactor30.33311.794GRIM-19 (PF06212, IPR009346): GRIM-19 protein
135 NEDD8interactor350.355171.669ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
136 NELFCDoncoprotein60.5332.845TH1 (PF04858, IPR006942): TH1 protein
137 NEURL4interactor70.38128.361Neuralized (PF07177, IPR006573, SM00588): Neuralized
138 NOMO2interactor100DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
DUF4198 (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
SdrD_B (PF17210): SdrD B-like domain
139 NPLOC4interactor130.41059.181NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
140 NPM1suppressor520.261864.833Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
141 NSD1oncoprotein70.23817.841PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
142 NTRK1oncoprotein970.1225490.148I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
143 OAS3interactor31.0000NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
144 P3H1interactor90.36157.535TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
145 PAF1oncoprotein100.62218.212Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
146 PARK2suppressor420.162556.609IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
147 PARP1suppressor280.288241.639BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
148 PARVAoncoprotein31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
149 PDE1Binteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
PDEase_I_N (PF08499, IPR013706): 3'5'-cyclic nucleotide phosphodiesterase N-terminal
150 PDIA3interactor130.44937.265Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
151 PDIA6interactor170.316148.936FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
152 PGRsuppressor100.63923.979Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
153 PHF6suppressor60.8000.765zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
YqfQ (PF14181, IPR025571): YqfQ-like protein
154 PHKA2interactor50.60010.378Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
155 PHKBinteractor60.6007.321Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
156 PHKG1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
157 PHKG2interactor60.6678.062APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
158 PLAURoncoprotein30.6671.061Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
159 PMLsuppressor170.258187.715zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
160 POLE4interactor200CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
161 POLR2Aprotein found in more fusions230.251198.828RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
162 PRDX1oncoprotein250.290174.308AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
163 PRKCAinteractor80.57113.947C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
164 PRKDCprotein found in more fusions340.288369.686FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
165 PSAPoncoprotein60.4008.622SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
166 PSMC1interactor240.460116.059AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
167 PSMC3interactor230.46892.179AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
168 PSMD14interactor190.64352.661JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
169 PSMD3interactor180.54253.793Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
170 PSMD4interactor300.391202.839UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
171 PTPN3interactor30.3339.712FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
172 PUF60protein found in more fusions110.46711.693RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
173 RAD23Aoncoprotein240.47492.955UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
174 RAD23Bsuppressor200.416129.892K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
175 RARAoncoprotein130.227123.770zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
176 RBM39oncoprotein210.38672.962RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
177 RBX1oncoprotein250.395116.474zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
178 RMI1interactor100RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
RMI1_C (PF16099, IPR032199): Recq-mediated genome instability protein 1, C-terminal OB-fold
179 RNF146interactor90.21412.905WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
180 RNF168protein found in more fusions80.23828.023ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
181 RNF2interactor410.179816.337zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
182 RPS15Ainteractor240.275256.129Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
183 SACSinteractor30.33360.374DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
HEPN (PF05168, IPR007842, SM00748): HEPN domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DUF4368 (PF14287, IPR025378): Domain of unknown function (DUF4368)
ThaI (PF15514, IPR029128): Restriction endonuclease ThaI
184 SCAMP1interactor31.0000SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
185 SCRIBsuppressor40.33334.417Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SDA1 (PF05285, IPR007949): SDA1
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
186 SEC24Dinteractor21.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
Transp_Tc5_C (PF04236, IPR007350): Tc5 transposase C-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
187 SENP3interactor150.44857.231Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
188 SF3B3interactor220.333203.505CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
189 SFNsuppressor200.263184.83514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
190 SGK223interactor30.6672.225Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Serglycin (PF04360, IPR007455): Serglycin
191 SHBGoncoprotein50.33348.245Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
192 SHFM1interactor240.413102.222CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
193 SMURF1interactor240.25796.551C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
194 SOD1interactor80.5711.916Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
195 SPINK1interactor100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
196 SRPRBinteractor50.5004.218MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
197 SRSF9interactor140.286106.441RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
198 SUMO3interactor90.36150.401Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
199 SUZ12suppressor260.180211.572DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
200 TALDO1interactor21.0000TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
201 TATsuppressor200Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
TAT_ubiq (PF07706, IPR011715): Aminotransferase ubiquitination site
202 TBC1D14interactor30.33318.724Sds3 (PF08598, IPR013907): Sds3-like
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
203 TBCDinteractor90.33339.551HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
204 TCF19interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
205 TNPO3interactor40.6672.324HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
206 TONSLinteractor100.5838.374LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
207 TOP1oncoprotein300.349210.289DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
208 TP53suppressor650.1631869.287DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
209 TRIM29protein found in more fusions60.20028.748MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
210 TRIM65interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
211 TRPV5interactor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
212 TSC2suppressor80.6796.430Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
Tuberin (PF03542, IPR018515): Tuberin
DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
213 TTC3interactor40.66721.646DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
NuiA (PF07924, IPR012489): Nuclease A inhibitor-like protein
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
FlxA (PF14282, IPR025577): FlxA-like protein
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
214 TXNL1interactor160.67532.414PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
215 UBASH3Binteractor190.25589.329His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
216 UBBinteractor150.162112.519ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
217 UBCprotein found in more fusions710.2121889.507ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
218 UBE2D1interactor240.237248.701UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
219 UBE2D2oncoprotein240.253198.436UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
220 UBE2D3interactor170.200135.463UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
221 UBE2E1protein found in more fusions150.132251.095UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
222 UBE2L3interactor170.30088.158UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
223 UBE2L6protein found in more fusions5012.308UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
224 UBQLN1protein found in more fusions200.38687.776Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
225 UBQLN2protein found in more fusions140.48761.519Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
226 UBXN1interactor210.305121.173Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
227 UCHL5oncoprotein290.310243.452Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
228 UFD1Linteractor110.41832.951UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
229 UNC45Ainteractor110.34540.013Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
230 USP14interactor170.596116.914UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
231 VHLsuppressor280.271254.819Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
232 WDCPinteractor100DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
233 WDR12interactor60.4007.727NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
234 WDR5interactor250.280314.038WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
235 WDR61interactor130.38544.211WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
236 XRCC6oncoprotein410.227776.154Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
237 YBX1oncoprotein300.310178.810CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
238 YOD1interactor51.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
239 YWHAEoncoprotein290.305345.37114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
240 YWHAQinteractor380.249457.68914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
241 YWHAZprotein found in more fusions310.322300.36714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
242 ZC3H3interactor201.509zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
243 ZNF22interactor30.6671.509zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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