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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BICRA, VPS13B (from a repository: Sun Sep 15 09:34:51 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)16 (20.51 %)
The number (and %) of affected PPIs11 (68.75 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.000
Assortativity coefficient-0.3225
The network average Clustering coefficient0.106
The number (and %) of a zero Clustering coefficients10 (76.92 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,BICRA All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); SS18 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS13Bparental protein4060.000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 BICRAparental protein70.04890.000SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
3 BRD4oncoprotein100Caldesmon (PF02029, IPR006018): Caldesmon
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Stm1_N (PF09598, IPR019084): Stm1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
4 CSNK1Einteractor3064.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 DNAJC7interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
6 DYNC1H1interactor100AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
7 EWSR1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
9 NEIL3interactor100Fapy_DNA_glyco (PF01149, IPR012319, SM00898): Formamidopyrimidine-DNA glycosylase N-terminal domain
H2TH (PF06831, IPR015886): Formamidopyrimidine-DNA glycosylase H2TH domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
10 NFYCinteractor100CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fucose_iso_C (PF02952, IPR015888): L-fucose isomerase, C-terminal domain
11 SMARCD1interactor30.33370.000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
12 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 SS18oncoprotein31.0000SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor

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