Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNX12, FBXW8 (from a repository: Tue Jul 30 02:32:34 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins16 (23.88 %)
The number (and %) of the tumor suppressors11 (16.42 %)
Total number of binary PPIs (saturation %)335 (15.15 %)
The number (and %) of affected PPIs66 (19.70 %)
The number of possible different fusions14
PPI diameter4
PPI radius2
The average degree of PPI9.284
Assortativity coefficient-0.1788
The network average Clustering coefficient0.483
The number (and %) of a zero Clustering coefficients5 (7.46 %)
The number (and %) of a zero Betweenness Centrality8 (11.94 %)


List of the fusions

PPI for parental proteins: FBXW8,SNX12 All fusions
Proteins found in more fusions AHCYL1 (see 2 fusions); CUL4A (see 4 fusions); HSP90AA1 (see 6 fusions); GORASP1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); DDB1 (see 4 fusions); CCND1 (see 1 fusions); MAPK14 (see 1 fusions); MYC (see 2 fusions); TP53 (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FBXW8parental protein410.2061034.429WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
2 SNX12parental protein250.103971.421PX (PF00787, IPR001683, SM00312): PX domain
3 AHCYL1suppressor90.214101.486AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
4 AKR1A1interactor40.5005.800Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 APRTinteractor204.922Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
6 ARL6IP1interactor40.6671.400Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7 BCL3oncoprotein30.6670.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
8 BTRConcoprotein250.315251.478WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 CASQ2interactor41.0000Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
10 CCDC8interactor160.46780.611Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
11 CCND1oncoprotein110.57810.739Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
12 CCT2interactor170.57450.097Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT3interactor140.67029.199Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CCT6Ainteractor140.67029.199Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CCT6Binteractor61.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16 CCT7interactor120.71222.616Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CDC5Linteractor140.359131.672OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18 CLNS1Ainteractor2027.333Voldacs (PF03517): Regulator of volume decrease after cellular swelling
19 CUL1suppressor180.41985.823Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20 CUL2suppressor60.46721.047Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL4Aprotein found in more fusions110.8672.068Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 CUL7protein found in more fusions230.316285.434ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23 DAZAP1interactor100.244149.622RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
24 DDB1protein found in more fusions150.473112.854CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
25 DLDinteractor208.191Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
26 EP300oncoprotein120.45538.857Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
27 FBXO4interactor70.8670.440Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
F-box (PF00646, IPR001810, SM00256): F-box domain
28 FBXW2interactor70.5245.308WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
29 GNPDA2interactor30.6670.667Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
30 GORASP1protein found in more fusions31.0000GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
31 HGSinteractor30.6673.402FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
32 HSP90AA1oncoprotein180.41265.016HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
33 HSPA4interactor120.288120.138Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
34 IFI30oncoprotein100GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
35 IGBP1interactor90.38976.903TAP42 (PF04177, IPR007304): TAP42-like family
36 IRS1interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
37 MAP4K1suppressor60.8000.708CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK14oncoprotein110.42279.344Pkinase (PF00069, IPR000719): Protein kinase domain
39 MTAPsuppressor60.53312.039PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
40 MYConcoprotein200.386104.797HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
41 NFKBIAoncoprotein100.35638.136Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
42 NME1-NME2interactor60.53316.498NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
43 OBSL1interactor170.417119.011BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
44 PDCD5suppressor30.6671.657dsDNA_bind (PF01984, IPR002836): Double-stranded DNA-binding domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
45 PFDN5interactor60.6676.097Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
46 PIN1suppressor120.303165.451Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
47 PPIL3interactor50.7004.785Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
48 PPM1Ginteractor50.20028.593Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
49 PPP4R3Ainteractor30.3338.280Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
50 PSMC1interactor30.3339.056AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
51 RBX1oncoprotein160.42961.732zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
52 RESToncoprotein40.3336.733CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Presenilin (PF01080, IPR001108): Presenilin
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
53 RTN4suppressor40.33319.368CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
54 SKP1oncoprotein160.48389.768Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
55 SKP2suppressor120.65212.915LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
56 TAGLNsuppressor21.0000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
57 TAGLN2interactor120.333122.835Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
58 TAGLN3interactor60.60016.463Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
59 TBC1D3interactor21.0000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
60 TCP1interactor150.61935.042Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
61 TP53suppressor260.363375.923DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TRIP13interactor50.3332.087AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
63 TTC29interactor21.0000DUF1266 (PF06889, IPR009677): Protein of unknown function (DUF1266)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2225 (PF09986, IPR018708): Uncharacterized protein conserved in bacteria (DUF2225)
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
64 UBE2D3interactor60.6003.399UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 UBE2L3interactor80.09545.778UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
66 VBP1interactor40.50052.139Prefoldin (PF02996, IPR004127): Prefoldin subunit
67 XPO1interactor90.25054.529CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑