Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNX12, FBXW8 (from a repository: Tue Jul 30 02:32:34 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 67 The number (and %) of the onco-proteins 16 (23.88 %) The number (and %) of the tumor suppressors 11 (16.42 %) Total number of binary PPIs (saturation %) 335 (15.15 %) The number (and %) of affected PPIs 66 (19.70 %) The number of possible different fusions 14 PPI diameter 4 PPI radius 2 The average degree of PPI 9.284 Assortativity coefficient -0.1788 The network average Clustering coefficient 0.483 The number (and %) of a zero Clustering coefficients 5 (7.46 %) The number (and %) of a zero Betweenness Centrality 8 (11.94 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: FBXW8,SNX12	All fusions
Proteins found in more fusions	AHCYL1 (see 2 fusions); CUL4A (see 4 fusions); HSP90AA1 (see 6 fusions); GORASP1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); DDB1 (see 4 fusions); CCND1 (see 1 fusions); MAPK14 (see 1 fusions); MYC (see 2 fusions); TP53 (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	FBXW8	parental protein	41	0.206	1034.429	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
2	SNX12	parental protein	25	0.103	971.421	PX (PF00787, IPR001683, SM00312): PX domain
3	AHCYL1	suppressor	9	0.214	101.486	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
4	AKR1A1	interactor	4	0.500	5.800	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5	APRT	interactor	2	0	4.922	Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
6	ARL6IP1	interactor	4	0.667	1.400	Reticulon (PF02453, IPR003388): Reticulon TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7	BCL3	oncoprotein	3	0.667	0.667	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
8	BTRC	oncoprotein	25	0.315	251.478	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
9	CASQ2	interactor	4	1.000	0	Calsequestrin (PF01216, IPR001393): Calsequestrin SDA1 (PF05285, IPR007949): SDA1
10	CCDC8	interactor	16	0.467	80.611	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
11	CCND1	oncoprotein	11	0.578	10.739	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
12	CCT2	interactor	17	0.574	50.097	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13	CCT3	interactor	14	0.670	29.199	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14	CCT6A	interactor	14	0.670	29.199	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15	CCT6B	interactor	6	1.000	0	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16	CCT7	interactor	12	0.712	22.616	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17	CDC5L	interactor	14	0.359	131.672	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18	CLNS1A	interactor	2	0	27.333	Voldacs (PF03517): Regulator of volume decrease after cellular swelling
19	CUL1	suppressor	18	0.419	85.823	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20	CUL2	suppressor	6	0.467	21.047	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21	CUL4A	protein found in more fusions	11	0.867	2.068	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22	CUL7	protein found in more fusions	23	0.316	285.434	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23	DAZAP1	interactor	10	0.244	149.622	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
24	DDB1	protein found in more fusions	15	0.473	112.854	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
25	DLD	interactor	2	0	8.191	Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
26	EP300	oncoprotein	12	0.455	38.857	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
27	FBXO4	interactor	7	0.867	0.440	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A F-box (PF00646, IPR001810, SM00256): F-box domain
28	FBXW2	interactor	7	0.524	5.308	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
29	GNPDA2	interactor	3	0.667	0.667	Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
30	GORASP1	protein found in more fusions	3	1.000	0	GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
31	HGS	interactor	3	0.667	3.402	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
32	HSP90AA1	oncoprotein	18	0.412	65.016	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
33	HSPA4	interactor	12	0.288	120.138	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
34	IFI30	oncoprotein	1	0	0	GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
35	IGBP1	interactor	9	0.389	76.903	TAP42 (PF04177, IPR007304): TAP42-like family
36	IRS1	interactor	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
37	MAP4K1	suppressor	6	0.800	0.708	CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain
38	MAPK14	oncoprotein	11	0.422	79.344	Pkinase (PF00069, IPR000719): Protein kinase domain
39	MTAP	suppressor	6	0.533	12.039	PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
40	MYC	oncoprotein	20	0.386	104.797	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
41	NFKBIA	oncoprotein	10	0.356	38.136	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
42	NME1-NME2	interactor	6	0.533	16.498	NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
43	OBSL1	interactor	17	0.417	119.011	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
44	PDCD5	suppressor	3	0.667	1.657	dsDNA_bind (PF01984, IPR002836): Double-stranded DNA-binding domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
45	PFDN5	interactor	6	0.667	6.097	Prefoldin (PF02996, IPR004127): Prefoldin subunit UPF0693 (PF16088, IPR032143): UPF0693 family
46	PIN1	suppressor	12	0.303	165.451	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
47	PPIL3	interactor	5	0.700	4.785	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
48	PPM1G	interactor	5	0.200	28.593	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PP2C (PF00481, IPR001932): Protein phosphatase 2C DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
49	PPP4R3A	interactor	3	0.333	8.280	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1 WH1 (PF00568, IPR000697, SM00461): WH1 domain DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
50	PSMC1	interactor	3	0.333	9.056	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
51	RBX1	oncoprotein	16	0.429	61.732	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
52	REST	oncoprotein	4	0.333	6.733	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Presenilin (PF01080, IPR001108): Presenilin RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
53	RTN4	suppressor	4	0.333	19.368	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Reticulon (PF02453, IPR003388): Reticulon Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
54	SKP1	oncoprotein	16	0.483	89.768	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
55	SKP2	suppressor	12	0.652	12.915	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
56	TAGLN	suppressor	2	1.000	0	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
57	TAGLN2	interactor	12	0.333	122.835	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
58	TAGLN3	interactor	6	0.600	16.463	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
59	TBC1D3	interactor	2	1.000	0	RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
60	TCP1	interactor	15	0.619	35.042	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
61	TP53	suppressor	26	0.363	375.923	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62	TRIP13	interactor	5	0.333	2.087	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
63	TTC29	interactor	2	1.000	0	DUF1266 (PF06889, IPR009677): Protein of unknown function (DUF1266) TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2225 (PF09986, IPR018708): Uncharacterized protein conserved in bacteria (DUF2225) TPR_12 (PF13424): Tetratricopeptide repeat TPR_20 (PF14561): Tetratricopeptide repeat
64	UBE2D3	interactor	6	0.600	3.399	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65	UBE2L3	interactor	8	0.095	45.778	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
66	VBP1	interactor	4	0.500	52.139	Prefoldin (PF02996, IPR004127): Prefoldin subunit
67	XPO1	interactor	9	0.250	54.529	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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