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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins16 (23.88 %)
The number (and %) of the tumor suppressors11 (16.42 %)
Total number of binary PPIs (saturation %)335 (15.15 %)
The number (and %) of affected PPIs66 (19.70 %)
The number of possible different fusions14
PPI diameter4
PPI radius2
The average degree of PPI9.284
Assortativity coefficient-0.1788
The network average Clustering coefficient0.483
The number (and %) of a zero Clustering coefficients5 (7.46 %)
The number (and %) of a zero Betweenness Centrality8 (11.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FBXW8,SNX12 All fusions
Proteins found in more fusions AHCYL1 (see 2 fusions); CUL4A (see 4 fusions); HSP90AA1 (see 6 fusions); GORASP1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); DDB1 (see 4 fusions); CCND1 (see 1 fusions); MAPK14 (see 1 fusions); MYC (see 2 fusions); TP53 (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FBXW8parental protein410.2061034.429WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
2 SNX12parental protein250.103971.421PX (PF00787, IPR001683, SM00312): PX domain
3 AHCYL1suppressor90.214101.486AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
4 AKR1A1interactor40.5005.800Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 APRTinteractor204.922Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
6 ARL6IP1interactor40.6671.400Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7 BCL3oncoprotein30.6670.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
8 BTRConcoprotein250.315251.478WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 CASQ2interactor41.0000Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
10 CCDC8interactor160.46780.611Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
11 CCND1oncoprotein110.57810.739Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
12 CCT2interactor170.57450.097Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT3interactor140.67029.199Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CCT6Ainteractor140.67029.199Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CCT6Binteractor61.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16 CCT7interactor120.71222.616Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CDC5Linteractor140.359131.672OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18 CLNS1Ainteractor2027.333Voldacs (PF03517): Regulator of volume decrease after cellular swelling
19 CUL1suppressor180.41985.823Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20 CUL2suppressor60.46721.047Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL4Aprotein found in more fusions110.8672.068Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 CUL7protein found in more fusions230.316285.434ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23 DAZAP1interactor100.244149.622RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
24 DDB1protein found in more fusions150.473112.854CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
25 DLDinteractor208.191Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
26 EP300oncoprotein120.45538.857Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
27 FBXO4interactor70.8670.440Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
F-box (PF00646, IPR001810, SM00256): F-box domain
28 FBXW2interactor70.5245.308WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
29 GNPDA2interactor30.6670.667Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
30 GORASP1protein found in more fusions31.0000GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
31 HGSinteractor30.6673.402FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
32 HSP90AA1oncoprotein180.41265.016HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
33 HSPA4interactor120.288120.138Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
34 IFI30oncoprotein100GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
35 IGBP1interactor90.38976.903TAP42 (PF04177, IPR007304): TAP42-like family
36 IRS1interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
37 MAP4K1suppressor60.8000.708CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK14oncoprotein110.42279.344Pkinase (PF00069, IPR000719): Protein kinase domain
39 MTAPsuppressor60.53312.039PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
40 MYConcoprotein200.386104.797HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
41 NFKBIAoncoprotein100.35638.136Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
42 NME1-NME2interactor60.53316.498NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
43 OBSL1interactor170.417119.011BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
44 PDCD5suppressor30.6671.657dsDNA_bind (PF01984, IPR002836): Double-stranded DNA-binding domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
45 PFDN5interactor60.6676.097Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
46 PIN1suppressor120.303165.451Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
47 PPIL3interactor50.7004.785Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
48 PPM1Ginteractor50.20028.593Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
49 PPP4R3Ainteractor30.3338.280Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
50 PSMC1interactor30.3339.056AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
51 RBX1oncoprotein160.42961.732zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
52 RESToncoprotein40.3336.733CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Presenilin (PF01080, IPR001108): Presenilin
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
53 RTN4suppressor40.33319.368CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
54 SKP1oncoprotein160.48389.768Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
55 SKP2suppressor120.65212.915LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
56 TAGLNsuppressor21.0000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
57 TAGLN2interactor120.333122.835Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
58 TAGLN3interactor60.60016.463Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
59 TBC1D3interactor21.0000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
60 TCP1interactor150.61935.042Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
61 TP53suppressor260.363375.923DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TRIP13interactor50.3332.087AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
63 TTC29interactor21.0000DUF1266 (PF06889, IPR009677): Protein of unknown function (DUF1266)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2225 (PF09986, IPR018708): Uncharacterized protein conserved in bacteria (DUF2225)
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
64 UBE2D3interactor60.6003.399UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 UBE2L3interactor80.09545.778UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
66 VBP1interactor40.50052.139Prefoldin (PF02996, IPR004127): Prefoldin subunit
67 XPO1interactor90.25054.529CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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