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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIGL, SNX8 (from a repository: Sat Aug 24 13:19:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)18 (23.08 %)
The number (and %) of affected PPIs11 (61.11 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.154
Assortativity coefficient-0.3484
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality11 (84.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIGL,SNX8 All fusions
Proteins found in more fusions MEIS2 (see 1 fusions); TOLLIP (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIGLparental protein100PIG-L (PF02585, IPR003737): GlcNAc-PI de-N-acetylase
2 SNX8parental protein100.06783.000Perilipin (PF03036, IPR004279): Perilipin family
PX (PF00787, IPR001683, SM00312): PX domain
3 ATP6V1Dinteractor100ATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
4 FBXW7suppressor40.6671.000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
5 KARSinteractor21.0000tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
6 MEIS2protein found in more fusions200Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
7 MOV10interactor21.0000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
8 MSH3oncoprotein21.0000MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
9 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
10 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
11 THUMPD2interactor100THUMP (PF02926, IPR004114, SM00981): THUMP domain
UPF0020 (PF01170, IPR000241): Putative RNA methylase family UPF0020
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
12 TOLLIPprotein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
13 ZWILCHinteractor100DUF2352 (PF09817, IPR018630): Uncharacterized conserved protein (DUF2352)

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