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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SHMT1, TFCP2L1 (from a repository: Wed Dec 11 19:40:02 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins10 (21.74 %)
The number (and %) of the tumor suppressors6 (13.04 %)
Total number of binary PPIs (saturation %)136 (13.14 %)
The number (and %) of affected PPIs45 (33.09 %)
The number of possible different fusions9
PPI diameter2
PPI radiusinf
The average degree of PPI5.348
Assortativity coefficient-0.4096
The network average Clustering coefficient0.453
The number (and %) of a zero Clustering coefficients16 (34.78 %)
The number (and %) of a zero Betweenness Centrality20 (43.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TFCP2L1,SHMT1 All fusions
Proteins found in more fusions APEH (see 1 fusions); SMAD4 (see 2 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TFCP2L1parental protein306.000CP2 (PF04516, IPR007604): CP2 transcription factor
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
2 SHMT1parental protein420.0961313.305SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
3 APEHoncoprotein90.6435.786Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4 ARFIP1interactor50.7002.667Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
6 ATP6V1C1protein found in more fusions130.62113.671V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
7 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
8 CARSoncoprotein80.46412.333tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
9 CFAP20oncoprotein100DUF667 (PF05018, IPR007714): Protein of unknown function (DUF667)
10 CTTNoncoprotein100.6677.186FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
12 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
13 FAM129Binteractor60.9330.333PH (PF00169, IPR001849, SM00233): PH domain
14 GARSinteractor70.5717.167HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
15 GSPT2interactor70.9050.619GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
16 GTF2F2interactor100TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17 HARSinteractor50.6003.667HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
18 HIST1H4Ainteractor50.7002.667CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
19 HSPA1Linteractor100HSP70 (PF00012, IPR013126): Hsp70 protein
20 HSPE1interactor40.5003.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
21 IDEinteractor90.6676.452Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
22 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
23 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
24 MCATinteractor100Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
25 PAICSinteractor50.5003.000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
26 PAWRsuppressor110.61811.552ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
27 PBDC1interactor100Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
28 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
29 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
30 PPATinteractor30.6670.667Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
31 PRRC1interactor30.6671.000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
32 PRSS23interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
33 RBM8Ainteractor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 SHMT2interactor130.43636.586SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
36 SNX2interactor110.58215.819PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
37 SNX6interactor110.60015.386PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
38 STAT1suppressor120.7096.338SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
39 STXBP1interactor100Sec1 (PF00995, IPR001619): Sec1 family
40 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
41 TFAP4oncoprotein100DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
42 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
43 TTC1interactor70.5249.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
44 VPS29interactor80.8571.467Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
45 XPO5suppressor40.6672.000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
46 ZC3H4interactor100API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain

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