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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GUCY1A3, RANBP10 (from a repository: Thu Feb 8 04:12:35 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins7 (20.59 %)
The number (and %) of the tumor suppressors7 (20.59 %)
Total number of binary PPIs (saturation %)89 (15.86 %)
The number (and %) of affected PPIs32 (35.96 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.412
Assortativity coefficient-0.4555
The network average Clustering coefficient0.445
The number (and %) of a zero Clustering coefficients10 (29.41 %)
The number (and %) of a zero Betweenness Centrality16 (47.06 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RANBP10,GUCY1A3 All fusions
Proteins found in more fusions CSNK2A1 (see 1 fusions); NEDD4L (see 3 fusions); COPS5 (see 1 fusions); PRKCD (see 2 fusions); NEDD4 (see 1 fusions); STUB1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RANBP10parental protein250.093688.397LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
2 GUCY1A3parental protein70.38176.000HNOB (PF07700, IPR011644): Haem-NO-binding
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
3 CNTNAP4interactor100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
4 COPS4interactor41.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
5 COPS5protein found in more fusions60.60028.540JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 CSNK2A1oncoprotein60.60042.889Pkinase (PF00069, IPR000719): Protein kinase domain
7 DRD1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8 GDNFinteractor30.33353.207TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
9 GID8interactor110.48927.692LisH (PF08513, IPR013720, SM00667): LisH
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
10 GLIPR1L2interactor21.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
11 GPS2oncoprotein50.40093.143G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
12 HLA-DPB1interactor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 IGSF1interactor200UEV (PF05743, IPR008883): UEV domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
14 IKBKGinteractor200CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
15 MAPK8oncoprotein40.66714.018DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
16 MEGF10interactor100DSL (PF01414, IPR001774, SM00051): Delta serrate ligand
EGF_2 (PF07974, IPR013111): EGF-like domain
Syndecan (PF01034, IPR027789): Syndecan domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
17 METoncoprotein2044.278Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
18 MMP7interactor31.0000Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
19 MRPL39interactor40.50030.242TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
20 MRPL4interactor70.57175.139Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
21 NEDD4suppressor200Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
22 NEDD4Lsuppressor31.0000WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
23 NOTCH1suppressor40.6672.333Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
24 PRG2interactor41.0000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
25 PRKCDsuppressor40.33334.242Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
26 PRKCGinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
27 RANoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
28 RMND5Ainteractor120.36460.431CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SnoaL_4 (PF13577, IPR009959): SnoaL-like domain
29 SOX2oncoprotein70.8002.250HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
30 STUB1suppressor40.33319.111U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
31 TDGF1suppressor41.0000CFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
32 THSD7Binteractor100TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
DUF3709 (PF12493, IPR022178): Protein of unknown function (DUF3709)
DUF3961 (PF13106, IPR025081): Domain of unknown function (DUF3961)
33 TP53suppressor100.250115.692DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
34 WDR26interactor70.7624.397eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1

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