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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GRM8, SNX12 (from a repository: Wed Aug 14 07:59:10 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins1 (3.70 %)
The number (and %) of the tumor suppressors6 (22.22 %)
Total number of binary PPIs (saturation %)62 (17.66 %)
The number (and %) of affected PPIs25 (40.32 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI4.148
Assortativity coefficient-0.3729
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients5 (18.52 %)
The number (and %) of a zero Betweenness Centrality12 (44.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SNX12,GRM8 All fusions
Proteins found in more fusions TP53 (see 3 fusions); AHCYL1 (see 2 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNX12parental protein250.103480.500PX (PF00787, IPR001683, SM00312): PX domain
2 GRM8interactor0007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
3 AHCYL1suppressor70.4008.667AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
4 AKR1A1interactor40.5002.167Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 APRTinteractor100Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
6 ARL6IP1interactor40.6671.000Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7 CDC5Linteractor31.0000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
8 CLNS1Ainteractor100Voldacs (PF03517): Regulator of volume decrease after cellular swelling
9 DAZAP1interactor60.4676.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
10 DLDinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
11 GNPDA2interactor30.6670.667Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
12 HGSinteractor30.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
13 IFI30oncoprotein100GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
14 IGBP1interactor40.6672.000TAP42 (PF04177, IPR007304): TAP42-like family
15 MTAPsuppressor60.5335.500PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
16 NME1-NME2interactor60.5336.333NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
17 PIN1suppressor60.6005.000Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
18 PPIL3interactor50.7002.000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
19 PPM1Ginteractor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
20 PPP4R3Ainteractor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
21 PSMC1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
22 RTN4suppressor31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
23 TAGLNsuppressor21.0000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
24 TAGLN2interactor90.47215.167Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
25 TAGLN3interactor50.8001.167Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
26 TP53suppressor31.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
27 UBE2L3interactor40.6670.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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