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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTNNA3, PDE10A (from a repository: Tue Aug 6 07:54:33 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins5 (55.56 %)
The number (and %) of the tumor suppressors2 (22.22 %)
Total number of binary PPIs (saturation %)14 (38.89 %)
The number (and %) of affected PPIs7 (50.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.222
Assortativity coefficient-0.0680
The network average Clustering coefficient0.356
The number (and %) of a zero Clustering coefficients5 (55.56 %)
The number (and %) of a zero Betweenness Centrality8 (88.89 %)


List of the fusions

PPI for parental proteins: PDE10A,CTNNA3 All fusions
Proteins found in more fusions CTNNA1 (see 4 fusions); EHMT2 (see 1 fusions); EPS8 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PDE10Aparental protein100GAF (PF01590, IPR003018, SM00065): GAF domain
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
2 CTNNA3parental protein60.20024.000Vinculin (PF01044, IPR006077): Vinculin family
3 CTNNA1oncoprotein41.0000Vinculin (PF01044, IPR006077): Vinculin family
4 CTNNB1oncoprotein31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
5 EHMT2protein found in more fusions200CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
6 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 JUPsuppressor31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
8 SPRY2suppressor200KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
9 TOP1oncoprotein100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region

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