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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SSU72, PCBP3 (from a repository: Mon Dec 9 13:13:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins22 (41.51 %)
The number (and %) of the tumor suppressors2 (3.77 %)
Total number of binary PPIs (saturation %)110 (7.98 %)
The number (and %) of affected PPIs51 (46.36 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI3.396
Assortativity coefficient-0.3726
The network average Clustering coefficient0.377
The number (and %) of a zero Clustering coefficients23 (43.40 %)
The number (and %) of a zero Betweenness Centrality29 (54.72 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PCBP3,SSU72 All fusions
Proteins found in more fusions PFKL (see 2 fusions); FOS (see 4 fusions); VCL (see 2 fusions); POLR2A (see 2 fusions); PRDX6 (see 1 fusions); PTBP1 (see 1 fusions); MAPK9 (see 3 fusions); UBE2H (see 4 fusions); DNPH1 (see 1 fusions); ACAT2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PCBP3parental protein210.0331077.662KH_1 (PF00013, IPR004088, SM00322): KH domain
2 SSU72parental protein300.0511615.189Ssu72 (PF04722, IPR006811): Ssu72-like protein
3 ACAT2protein found in more fusions30121.775Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 AKR1B10interactor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 BBOX1interactor200DUF971 (PF06155, IPR010376): Protein of unknown function (DUF971)
TauD (PF02668, IPR003819): Taurine catabolism dioxygenase TauD, TfdA family
6 CEP128interactor30.333112.670DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
7 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
8 DLDinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
9 DNPH1protein found in more fusions200Nuc_deoxyrib_tr (PF05014, IPR007710): Nucleoside 2-deoxyribosyltransferase
10 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
11 FOSoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
12 FTH1interactor40.333122.737Coat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
13 KCTD17interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
14 KYNUinteractor21.0000Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
15 LACTB2interactor21.0000E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
16 MAPK8oncoprotein31.0000DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
17 MAPK9suppressor50.333141.189Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
18 NCAPG2interactor100Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
19 NUDCD2interactor30.6671.000CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
20 PCBP1oncoprotein60.333126.289Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
21 PCM1oncoprotein21.0000FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
22 PDCD2Linteractor2063.452PDCD2_C (PF04194, IPR007320): Programmed cell death protein 2, C-terminal putative domain
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
23 PFKLprotein found in more fusions30108.603PFK (PF00365, IPR000023): Phosphofructokinase
24 POLR2Aprotein found in more fusions70.333244.973RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
25 PPP1CBinteractor2090.803Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
26 PPP1R18interactor2070.403Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
27 PRDX6protein found in more fusions31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
28 PTBP1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
29 PTBP2interactor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
30 PTGES3interactor31.0000CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
31 RAD21oncoprotein50.600130.303Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
32 RBM39oncoprotein100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
33 RHODinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
34 RUVBL1oncoprotein50.66766.976TIP49 (PF06068, IPR010339): TIP49 C-terminus
35 RUVBL2oncoprotein60.500140.713TIP49 (PF06068, IPR010339): TIP49 C-terminus
36 SEC23IPinteractor60.33346.913DDHD (PF02862, IPR004177, SM01127): DDHD domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
WWE (PF02825, IPR004170, SM00678): WWE domain
37 SKP1oncoprotein100Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
38 SMC1Aoncoprotein60.8004.300SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
39 SMC3oncoprotein50.8004.300SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
40 SPENoncoprotein100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
41 STAG2oncoprotein41.0000AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
STAG (PF08514, IPR013721): STAG domain
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
42 STXBP2interactor100Sec1 (PF00995, IPR001619): Sec1 family
43 SYMPKinteractor100HEAT (PF02985, IPR000357): HEAT repeat
DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
44 THOP1interactor21.0000Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
45 TIPRLinteractor100TIP41 (PF04176, IPR007303): TIP41-like family
46 TPI1interactor50.5002.667TIM (PF00121, IPR000652): Triosephosphate isomerase
47 TRIOoncoprotein100T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
GRP (PF07172, IPR010800): Glycine rich protein family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pap_E4 (PF02711, IPR003861): E4 protein
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
48 TSTA3interactor2063.452Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
49 UBE2Hprotein found in more fusions50.5003.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
50 UGGT1interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
51 UIMC1suppressor100Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
52 VCLoncoprotein40.6678.056Vinculin (PF01044, IPR006077): Vinculin family
53 XPO1interactor80.179430.576CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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