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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM72A, MRPL15 (from a repository: Thu May 11 18:29:12 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins9 (15.79 %)
The number (and %) of the tumor suppressors1 (1.75 %)
Total number of binary PPIs (saturation %)477 (29.89 %)
The number (and %) of affected PPIs55 (11.53 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI16.421
Assortativity coefficient-0.1211
The network average Clustering coefficient0.648
The number (and %) of a zero Clustering coefficients4 (7.02 %)
The number (and %) of a zero Betweenness Centrality10 (17.54 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FAM72A,MRPL15 All fusions
Proteins found in more fusions FKBP8 (see 1 fusions); COPS5 (see 1 fusions); MRPL12 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FAM72Aparental protein100FAM72 (PF14976, IPR026768): FAM72 protein
2 MRPL15parental protein540.2891057.676Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
3 BTRConcoprotein110.6004.496WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
4 CAND1interactor220.53831.414Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CCNDBP1suppressor21.0000CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
6 COPS5protein found in more fusions150.61519.331JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 COX15interactor41.0000COX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
8 CYC1interactor100.48916.816Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
9 DLSToncoprotein50.7001.1502-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
10 EIF3Concoprotein21.0000eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
11 FKBP8protein found in more fusions31.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
12 HNRNPA1interactor280.65233.492RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 ILF3oncoprotein250.49350.563dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
14 MARC1interactor30.6671.000MOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
15 MOV10interactor160.50820.623AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
16 MPPED2interactor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
17 MRPL1interactor290.68226.843CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
18 MRPL10interactor160.8502.345Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
19 MRPL11interactor250.61746.352Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
20 MRPL12protein found in more fusions170.60813.680Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
21 MRPL13interactor260.66533.128Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
22 MRPL14interactor160.9750.296Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
23 MRPL16interactor210.78115.767Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
24 MRPL19interactor240.73615.322Ribosomal_L19 (PF01245, IPR001857): Ribosomal protein L19
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
25 MRPL20interactor120.8790.958Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
26 MRPL28interactor250.76312.422Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
27 MRPL3interactor220.71917.673Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
28 MRPL32interactor210.76711.199Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
29 MRPL37interactor270.62440.792PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
30 MRPL38interactor280.63040.705PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
31 MRPL39interactor310.58378.371TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
32 MRPL4interactor310.58358.744Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
33 MRPL40interactor230.67628.171MRP-L28 (PF09812, IPR019192): Mitochondrial ribosomal protein L28
34 MRPL45interactor210.7908.482Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
35 MRPL47interactor290.67527.224MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
36 MRPL50interactor250.71018.434Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
37 MRPL55interactor150.8861.543Mitoc_L55 (PF09776, IPR018615): Mitochondrial ribosomal protein L55
38 MRPL57interactor120.9700.223MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
39 MRPL58interactor280.65132.852RF-1 (PF00472, IPR000352): RF-1 domain
40 MRPL9interactor320.60951.120Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
41 MRPS30interactor280.70919.556PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
42 NDUFA12interactor41.0000NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
43 NDUFS4interactor80.42914.233ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
44 NOP9interactor21.0000PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
45 NTRK1oncoprotein200.47442.061I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46 NXF1interactor100.5006.353NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 OGDHinteractor100.46713.578E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
48 RHOUinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
49 RPL23Ainteractor90.8332.171Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
50 RPL6interactor170.59616.620Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
51 RPS14interactor100.7336.444Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
52 RPS2interactor130.61512.268Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
53 RPS8interactor270.53667.361Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
54 RUNDC3Ainteractor100Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
RUN (PF02759, IPR004012, SM00593): RUN domain
55 SCFD1interactor110.41814.079Sec1 (PF00995, IPR001619): Sec1 family
56 SOX2oncoprotein80.7141.851HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
57 TMEM177interactor80.9290.216NA

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