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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins WDR91, CCDC40 (from a repository: Wed Aug 14 09:09:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins5 (38.46 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)31 (39.74 %)
The number (and %) of affected PPIs11 (35.48 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI3.846
Assortativity coefficient-0.0288
The network average Clustering coefficient0.530
The number (and %) of a zero Clustering coefficients2 (15.38 %)
The number (and %) of a zero Betweenness Centrality4 (30.77 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: WDR91,CCDC40 All fusions
Proteins found in more fusions HUWE1 (see 4 fusions); APP (see 5 fusions); ARIH2 (see 2 fusions); CUL3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 WDR91parental protein100.26763.933WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WIYLD (PF10440, IPR018848): Ubiquitin-binding WIYLD domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
2 CCDC40parental protein100BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1269 (PF06897, IPR009200): Protein of unknown function (DUF1269)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
KIP1 (PF07765, IPR011684): KIP1-like protein
NuA4 (PF09340, IPR015418): Histone acetyltransferase subunit NuA4
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
3 APPprotein found in more fusions40.33322.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARIH2protein found in more fusions31.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 BAG6interactor31.0000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 CUL3protein found in more fusions60.60021.733Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 DLG3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 HUWE1oncoprotein60.6005.467BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
9 NTRK1oncoprotein80.42916.933I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
10 RAPGEF2interactor30.6670.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
11 SYNCRIPinteractor40.66714.933RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
12 WWOXsuppressor30.6670.667adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
13 XPO1interactor40.6671.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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