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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TATDN2, NSMCE2 (from a repository: Thu Aug 22 21:29:10 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins8 (22.86 %)
The number (and %) of the tumor suppressors3 (8.57 %)
Total number of binary PPIs (saturation %)100 (16.81 %)
The number (and %) of affected PPIs33 (33.00 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI4.971
Assortativity coefficient-0.1817
The network average Clustering coefficient0.487
The number (and %) of a zero Clustering coefficients11 (31.43 %)
The number (and %) of a zero Betweenness Centrality16 (45.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TATDN2,NSMCE2 All fusions
Proteins found in more fusions TXLNA (see 3 fusions); ILK (see 2 fusions); EWSR1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TATDN2parental protein80.071226.030TatD_DNase (PF01026, IPR001130): TatD related DNase
2 NSMCE2parental protein250.133733.402gpW (PF02831, IPR004174): gpW
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Transpos_assoc (PF13963, IPR029480): Transposase-associated domain
3 BRCA1suppressor70.400125.205BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
4 CCNJLinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 EID3interactor61.0000Nse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
6 ETV1oncoprotein100Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
7 EWSR1oncoprotein40.6671.819RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 FBXW11interactor50.33372.619WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 ILKsuppressor50.16753.971Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
10 MOV10interactor50.10051.178AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
11 MRPL4interactor21.0000Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
12 NIPSNAP1interactor3042.352NIPSNAP (PF07978, IPR012577): NIPSNAP
13 NSMCE1interactor70.9330.400SMC_Nse1 (PF07574, IPR011513): Nse1 non-SMC component of SMC5-6 complex
zf-RING-like (PF08746, IPR014857): RING-like domain
14 NSMCE3interactor60.9330.400MAGE (PF01454, IPR002190): MAGE family
15 NXF1interactor5042.344NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 PAN2interactor100RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
17 PDS5Ainteractor71.0000HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
18 PDS5Bsuppressor71.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HEAT (PF02985, IPR000357): HEAT repeat
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
DUF3665 (PF12427, IPR024614): Branched-chain amino acid aminotransferase
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
19 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
20 RAD21oncoprotein100.57850.256Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
21 SAMD1interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 SMC1Aoncoprotein90.85722.389SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
23 SMC3oncoprotein80.85722.389SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
24 SMC5interactor60.9330.400BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
Vac_Fusion (PF02346, IPR003436): Chordopoxvirus multifunctional envelope protein A27
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
AAA_23 (PF13476): AAA domain
YqjK (PF13997, IPR025612): YqjK-like protein
Cache_3-Cache_2 (PF17201): Cache 3/Cache 2 fusion domain
25 SMC6interactor70.9330.400SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
26 SORT1interactor21.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
27 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
28 STAG2oncoprotein71.0000AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
STAG (PF08514, IPR013721): STAG domain
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
29 SYNCRIPinteractor50.300101.952RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
30 TM9SF4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
31 TSNAXinteractor21.0000Translin (PF01997, IPR002848): Translin family
32 TXLNAprotein found in more fusions5062.105Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
33 USP28interactor200TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
34 WAPLinteractor90.85722.389WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
35 ZNF597interactor61.0000zf-RING_7 (PF02591, IPR003743): C4-type zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)

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