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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC13A5, CLN8 (from a repository: Mon Jul 29 02:18:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins4 (12.50 %)
The number (and %) of the tumor suppressors4 (12.50 %)
Total number of binary PPIs (saturation %)43 (8.67 %)
The number (and %) of affected PPIs30 (69.77 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.375
Assortativity coefficient-0.5180
The network average Clustering coefficient0.240
The number (and %) of a zero Clustering coefficients22 (68.75 %)
The number (and %) of a zero Betweenness Centrality27 (84.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLN8,SLC13A5 All fusions
Proteins found in more fusions PLP2 (see 1 fusions); UBC (see 7 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLN8parental protein300.018849.000TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
2 SLC13A5interactor000NA
3 ARL6IP5suppressor21.0000PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
4 BNIP3oncoprotein41.0000BNIP3 (PF06553, IPR010548): BNIP3
5 BNIP3Lsuppressor50.6672.000BNIP3 (PF06553, IPR010548): BNIP3
6 C14orf1interactor100Erg28 (PF03694, IPR005352): Erg28 like protein
7 CD9oncoprotein100Tetraspannin (PF00335, IPR018499): Tetraspanin family
8 CYB5Binteractor100Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
9 GABARAPL2interactor30.6671.000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
10 GPM6Binteractor100PspB (PF06667, IPR009554): Phage shock protein B
Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
11 MTX1interactor100Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
12 NDRG2suppressor100Ndr (PF03096, IPR004142): Ndr family
13 PDIA6interactor100FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
14 PLP1interactor21.0000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
15 PLP2protein found in more fusions200MARVEL (PF01284, IPR008253): Membrane-associating domain
16 PTPRNinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Receptor_IA-2 (PF11548, IPR021613): Protein-tyrosine phosphatase receptor IA-2
RESP18 (PF14948, IPR029403): RESP18 domain
17 RRP15interactor100Rrp15p (PF07890, IPR012459): Rrp15p
18 RTN4suppressor40.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
19 SELENOKinteractor100SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
20 SPCS2interactor100SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
21 STX8interactor100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
SNARE (PF05739, IPR000727, SM00397): SNARE domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
22 TMEM107interactor100TMEM107 (PF14995, IPR029248): Transmembrane protein
23 TMEM11interactor31.0000Mito_morph_reg (PF14972, IPR026120): Mitochondrial morphogenesis regulator
24 TMEM128interactor100NA
25 TMEM134interactor100CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
26 TMEM147interactor100DUF2053 (PF09767, IPR019164): Predicted membrane protein (DUF2053)
27 TMEM14Ainteractor100Tmemb_14 (PF03647, IPR005349): Transmembrane proteins 14C
28 TUBB4Ainteractor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
29 UBCprotein found in more fusions200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 VAPAinteractor30.6671.000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
31 YIPF6interactor100Yip1 (PF04893, IPR006977): Yip1 domain
32 ZUFSPinteractor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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