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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FRMD4A, ANGPT1 (from a repository: Fri Jul 19 12:08:27 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins1 (12.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)8 (28.57 %)
The number (and %) of affected PPIs6 (75.00 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI1.500
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients8 (100.00 %)
The number (and %) of a zero Betweenness Centrality6 (75.00 %)


List of the fusions

PPI for parental proteins: ANGPT1,FRMD4A All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ANGPT1parental protein202.000DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
2 FRMD4Aparental protein4012.000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
DUF3338 (PF11819, IPR021774): Domain of unknown function (DUF3338)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
3 HNRNPA1interactor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
4 MAPK8IP2interactor200BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 TEKoncoprotein100EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
Ig_3 (PF13927): Immunoglobulin domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
6 TRAF3IP1interactor100MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
7 WDR83interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 YEATS4interactor100YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA

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