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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins H19, LAMA5 (from a repository: Thu Feb 16 04:00:57 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins3 (16.67 %)
The number (and %) of the tumor suppressors2 (11.11 %)
Total number of binary PPIs (saturation %)22 (14.38 %)
The number (and %) of affected PPIs16 (72.73 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI1.889
Assortativity coefficient-0.2919
The network average Clustering coefficient0.112
The number (and %) of a zero Clustering coefficients15 (83.33 %)
The number (and %) of a zero Betweenness Centrality17 (94.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LAMA5,H19 All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LAMA5parental protein150.010208.000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
2 H19parental protein100NA
3 AGO2interactor100ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 BCAMinteractor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
5 COL7A1oncoprotein100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF4249 (PF14054, IPR025345): Domain of unknown function (DUF4249)
DUF4992 (PF16383, IPR032155): Domain of unknown function
6 CRKLoncoprotein100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DAG1interactor100DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
8 FBLN2interactor200ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Metallothio_6 (PF05522, IPR017980): Metallothionein
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
9 FBXO6interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
10 LAMC1interactor21.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_I (PF06008, IPR009254): Laminin Domain I
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
11 MEP1Ainteractor200Astacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
12 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
13 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
14 RNASEH2Ainteractor100RNase_HII (PF01351, IPR024567): Ribonuclease HII
15 SMAD2suppressor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
16 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
17 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
18 USP4oncoprotein200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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