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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins15 (29.41 %)
The number (and %) of the tumor suppressors6 (11.76 %)
Total number of binary PPIs (saturation %)192 (15.06 %)
The number (and %) of affected PPIs49 (25.52 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI6.667
Assortativity coefficient-0.1503
The network average Clustering coefficient0.465
The number (and %) of a zero Clustering coefficients12 (23.53 %)
The number (and %) of a zero Betweenness Centrality17 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GPI,KIAA0355 All fusions
Proteins found in more fusions SORD (see 1 fusions); CUL7 (see 2 fusions); HUWE1 (see 4 fusions); PCNA (see 1 fusions); ENO1/ENO3 (see 1 fusions); BAG3 (see 4 fusions); PRDX6 (see 2 fusions); TKT (see 5 fusions); GPI/SORD (see 1 fusions); DCXR (see 2 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GPIparental protein440.1211463.634PGI (PF00342, IPR001672): Phosphoglucose isomerase
2 KIAA0355parental protein50.100288.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
DUF4745 (PF15923, IPR031813): Domain of unknown function (DUF4745)
3 ABATinteractor70.5246.058Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 ADCK2interactor200ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
5 AKR1A1interactor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
6 ALDH4A1interactor60.8000.786Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
7 AMFRoncoprotein31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
8 ANXA7suppressor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
9 ASB15interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
10 BAG3oncoprotein90.321126.660BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
11 CCP110interactor40.6673.643DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
12 CDK2suppressor130.54517.101Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
13 CUL7protein found in more fusions120.45586.333ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14 DCXRprotein found in more fusions200adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
15 ENO1oncoprotein190.35779.600Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
16 ENO3protein found in more fusions50.9000.400Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 ESDinteractor80.6674.134Esterase (PF00756, IPR000801): Putative esterase
18 FBXW11interactor60.200146.838WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 FHsuppressor50.8000.619Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
20 FUSsuppressor110.50989.974Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
21 GOT2oncoprotein60.7331.079Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
22 HUWE1oncoprotein80.57156.316BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
23 ISG15suppressor60.6672.033ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
24 KRBOX4interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
25 LACTB2interactor30.6670.333E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
26 MKS1interactor100B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
27 MRPL45interactor21.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
28 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
29 NEURL4interactor21.0000Neuralized (PF07177, IPR006573, SM00588): Neuralized
30 NTRK1oncoprotein210.342219.145I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 OBSL1interactor80.8570.835BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
32 PARP14interactor100Macro (PF01661, IPR002589, SM00506): Macro domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
WWE (PF02825, IPR004170, SM00678): WWE domain
Syntaxin_2 (PF14523): Syntaxin-like protein
33 PCNAoncoprotein130.60611.587PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
34 PDCD6IPinteractor110.51117.918BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
35 PEF1interactor40.8330.333EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
36 PGM1interactor90.55610.044PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
37 PGM5interactor100PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
38 PPME1interactor60.8000.536Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
39 PRDX6protein found in more fusions120.45522.170AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
40 RAB10oncoprotein30.6670.333Ras (PF00071, IPR001806, SM00173): Ras family
41 SDHBsuppressor30.6671.000Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
42 SORDprotein found in more fusions60.8000.667ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
43 SPICE1interactor100SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
44 SPRYD4interactor200SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
45 TAMM41interactor200Mmp37 (PF09139, IPR015222): Mitochondrial matrix Mmp37
46 TKTprotein found in more fusions190.32089.091Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
47 TMEM256interactor100DUF423 (PF04241, IPR006696): Protein of unknown function (DUF423)
DUF2648 (PF10855, IPR022561): Protein of unknown function (DUF2648)
48 TPI1interactor160.47631.033TIM (PF00121, IPR000652): Triosephosphate isomerase
49 U2AF2protein found in more fusions110.5568.316RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
50 WDR1interactor110.47320.998eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
51 YWHABinteractor50.200222.45214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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