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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)127
The number (and %) of the onco-proteins36 (28.35 %)
The number (and %) of the tumor suppressors15 (11.81 %)
Total number of binary PPIs (saturation %)612 (7.65 %)
The number (and %) of affected PPIs126 (20.59 %)
The number of possible different fusions20
PPI diameter4
PPI radius3
The average degree of PPI8.850
Assortativity coefficient-0.2930
The network average Clustering coefficient0.425
The number (and %) of a zero Clustering coefficients16 (12.60 %)
The number (and %) of a zero Betweenness Centrality26 (20.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GNB1,CASP7 All fusions
Proteins found in more fusions SAT1 (see 5 fusions); BIRC6 (see 1 fusions); CUL4A (see 4 fusions); VCP (see 4 fusions); CASP2 (see 3 fusions); NR3C1 (see 8 fusions); GNAS (see 5 fusions); HDAC4 (see 1 fusions); FYN (see 1 fusions); SP1 (see 1 fusions); TNFRSF1A (see 2 fusions); UBQLN1 (see 2 fusions); RACK1 (see 3 fusions); HDAC5 (see 1 fusions); PTK2 (see 2 fusions); PARP1 (see 1 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); STAT1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GNB1parental protein800.0557671.643Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
2 CASP7parental protein460.1481831.568Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ABCE1interactor140.141478.016ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ADRA2Ainteractor40.6670.4007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 ADRB2interactor140.154229.5527tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 AFPinteractor2067.786Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
7 AKT1oncoprotein120.291168.837PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8 ARHGDIAinteractor130.227199.153Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
9 ARHGEF18interactor2023.648PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10 ARRB1interactor90.222137.059Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11 ATP6V1B1interactor208.609ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
12 ATXN10interactor50.40029.715RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
13 AVPR2interactor40.50015.7037tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
14 BAXsuppressor80.8108.036Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
15 BIRC2oncoprotein120.7458.711BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
16 BIRC3oncoprotein100.8333.311BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
17 BIRC5interactor90.64367.802BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
18 BIRC6oncoprotein51.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
SlyX (PF04102, IPR007236): SlyX
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
19 BIRC7interactor61.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20 BTKsuppressor50.5003.749BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21 CAPN1interactor130.487165.437Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
22 CASP10interactor120.7459.763DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
23 CASP2suppressor110.73348.151CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
24 CASP3interactor300.217661.649Peptidase_C14 (PF00656, IPR011600): Caspase domain
25 CASP8suppressor200.374125.358DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
26 CASP9oncoprotein150.52464.085CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
27 CCDC8interactor150.176154.093Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
28 CCT2interactor120.258137.459Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
29 CCT5interactor100.44440.687Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
30 CEP128interactor40.5002.754DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31 CLSPNinteractor30.3334.136Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
Presenilin (PF01080, IPR001108): Presenilin
PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
32 CNDP2suppressor80.9290.667Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
33 COPS6interactor100.27879.929DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
34 COX4I1interactor100COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
35 CRYABoncoprotein80.9520.333Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
36 CTSAinteractor50.60041.106Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
37 CUL4Aprotein found in more fusions90.25065.491Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
38 CYFIP1interactor30.33324.598DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
39 DFFAsuppressor40.50023.714CIDE-N (PF02017, IPR003508): CIDE-N domain
DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain
T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
40 DISC1interactor40.16746.363HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
41 EEF2interactor140.275197.352EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
42 EIF4Hinteractor60.60067.060eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 ELAVL1oncoprotein240.1781009.831RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44 EPHA7oncoprotein100EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
45 ESR1suppressor210.168515.976Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
46 ESRRBsuppressor3033.452zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
47 FBXW11interactor70.33371.126WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
48 FYNoncoprotein100.278104.215Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
49 GBP2interactor80.7868.002GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
50 GINS2interactor90.66714.589Sld5 (PF05916, IPR021151): GINS complex protein
51 GLI1suppressor30.6671.778zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
52 GNA11oncoprotein60.40018.351G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
53 GNAI1oncoprotein130.35961.178G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
54 GNAI2oncoprotein180.235131.304G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
55 GNAI3interactor170.287225.048G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
56 GNAQoncoprotein70.33325.234G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
57 GNASoncoprotein160.200198.246G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
58 GNG10interactor50.7001.404G-gamma (PF00631, IPR015898, SM00224): GGL domain
59 GNG11interactor21.0000G-gamma (PF00631, IPR015898, SM00224): GGL domain
60 GNG12interactor40.5001.862G-gamma (PF00631, IPR015898, SM00224): GGL domain
61 GNG13interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
62 GNG2interactor180.183173.129G-gamma (PF00631, IPR015898, SM00224): GGL domain
SidE (PF12252, IPR021014): Dot/Icm substrate protein
63 GNG3interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
64 GNG4interactor50.7001.404G-gamma (PF00631, IPR015898, SM00224): GGL domain
65 GNG5interactor60.5338.949G-gamma (PF00631, IPR015898, SM00224): GGL domain
66 GNG7interactor41.0000G-gamma (PF00631, IPR015898, SM00224): GGL domain
67 GNG8interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
68 GNGT1interactor21.0000G-gamma (PF00631, IPR015898, SM00224): GGL domain
69 GNGT2interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
70 GNSinteractor80.75071.195Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
71 GRK2interactor50.4007.048ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
72 GZMBinteractor50.7002.274Trypsin (PF00089, IPR001254, SM00020): Trypsin
73 HDAC4oncoprotein70.33341.388Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
74 HDAC5protein found in more fusions100.38945.451Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
75 HSPA5oncoprotein150.176198.627HSP70 (PF00012, IPR013126): Hsp70 protein
76 KALRNoncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spectrin (PF00435, IPR002017): Spectrin repeat
UPF0302 (PF08864, IPR014963): UPF0302 domain
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
77 KCNJ3interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
78 MCF2oncoprotein200PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
79 MCF2Linteractor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4771 (PF15995, IPR031936): Domain of unknown function (DUF4771)
80 MRGPRX1interactor40.5001.5677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
RAMP4 (PF06624, IPR010580): Ribosome associated membrane protein RAMP4
81 MTNR1Ainteractor70.38122.0517tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
82 MTORoncoprotein120.34590.587DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
83 MVDinteractor100.8063.862GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
84 NCF2interactor41.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_16 (PF13432): Tetratricopeptide repeat
85 NOL11interactor2036.190NUC205 (PF08168, IPR012584): NUC205 domain
DUF2779 (PF11074, IPR021301): Domain of unknown function(DUF2779)
86 NR3C1protein found in more fusions80.28678.534GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
87 NTRK1oncoprotein310.1331119.720I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
88 PAK1oncoprotein41.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
89 PAN2interactor120.212107.945RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
90 PARP1suppressor140.179157.950BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
91 PDCLinteractor70.38142.136Phosducin (PF02114, IPR024253): Phosducin
92 PDLIM7interactor80.32152.870LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
93 PEPDinteractor100.66722.782AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
94 PIK3CGoncoprotein31.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244)
DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
95 PIK3R5oncoprotein31.0000PI3K_1B_p101 (PF10486, IPR019522): Phosphoinositide 3-kinase gamma adapter protein p101 subunit
96 PLA2G4Binteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
97 PLEKHG2oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
98 PTGES3interactor80.238100.759CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99 PTK2protein found in more fusions80.42934.499FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
100 RACK1suppressor150.209338.096WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
101 RADILinteractor21.0000DIL (PF01843, IPR018444, SM01132): DIL domain
FHA (PF00498, IPR000253, SM00240): FHA domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
102 RAP1Asuppressor80.28687.573Ras (PF00071, IPR001806, SM00173): Ras family
103 RASD1interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Ras (PF00071, IPR001806, SM00173): Ras family
104 RASD2interactor100Ras (PF00071, IPR001806, SM00173): Ras family
105 RB1suppressor80.46477.260RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
106 RGS6interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
107 RICTORinteractor70.6676.626RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
108 ROCK1interactor40.16721.251FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
ZapB (PF06005, IPR009252): Cell division protein ZapB
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PH (PF00169, IPR001849, SM00233): PH domain
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Rho_Binding (PF08912, IPR015008): Rho Binding
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
109 RPS6KA1oncoprotein140.440306.220Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
110 RPTORprotein found in more fusions100.444100.968HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
111 SAT1protein found in more fusions50.33330.120Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
112 SP1protein found in more fusions90.32172.012zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
113 SPAG1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
TPR_19 (PF14559): Tetratricopeptide repeat
114 SPTAN1oncoprotein160.242270.883EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
115 STAT1suppressor130.227104.944SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
116 SVILinteractor100.33347.818Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
117 SYNPOinteractor70.47616.015Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
118 TBXA2Rinteractor80.47610.1077tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
119 TERF1interactor90.143150.806TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
120 TNFRSF1Aoncoprotein120.345159.242Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
121 UBQLN1protein found in more fusions60.40054.985Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
122 VCAM1interactor110.327141.531C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
123 VCPprotein found in more fusions260.170624.965AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
124 VIMsuppressor160.248205.157Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
125 WDR26interactor40.5002.952eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
126 XIAPinteractor180.397336.708BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
127 XPO1interactor220.199483.769CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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