Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GNB1, CASP7 (from a repository: Wed Feb 15 14:45:12 2017)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 127 The number (and %) of the onco-proteins 36 (28.35 %) The number (and %) of the tumor suppressors 15 (11.81 %) Total number of binary PPIs (saturation %) 612 (7.65 %) The number (and %) of affected PPIs 126 (20.59 %) The number of possible different fusions 20 PPI diameter 4 PPI radius 3 The average degree of PPI 8.850 Assortativity coefficient -0.2930 The network average Clustering coefficient 0.425 The number (and %) of a zero Clustering coefficients 16 (12.60 %) The number (and %) of a zero Betweenness Centrality 26 (20.47 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GNB1,CASP7	All fusions
Proteins found in more fusions	SAT1 (see 5 fusions); BIRC6 (see 1 fusions); CUL4A (see 4 fusions); VCP (see 4 fusions); CASP2 (see 3 fusions); NR3C1 (see 8 fusions); GNAS (see 5 fusions); HDAC4 (see 1 fusions); FYN (see 1 fusions); SP1 (see 1 fusions); TNFRSF1A (see 2 fusions); UBQLN1 (see 2 fusions); RACK1 (see 3 fusions); HDAC5 (see 1 fusions); PTK2 (see 2 fusions); PARP1 (see 1 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); STAT1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GNB1	parental protein	80	0.055	7671.643	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
2	CASP7	parental protein	46	0.148	1831.568	Peptidase_C14 (PF00656, IPR011600): Caspase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
3	ABCE1	interactor	14	0.141	478.016	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
4	ADRA2A	interactor	4	0.667	0.400	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5	ADRB2	interactor	14	0.154	229.552	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6	AFP	interactor	2	0	67.786	Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
7	AKT1	oncoprotein	12	0.291	168.837	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	ARHGDIA	interactor	13	0.227	199.153	Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
9	ARHGEF18	interactor	2	0	23.648	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10	ARRB1	interactor	9	0.222	137.059	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11	ATP6V1B1	interactor	2	0	8.609	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
12	ATXN10	interactor	5	0.400	29.715	RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
13	AVPR2	interactor	4	0.500	15.703	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
14	BAX	suppressor	8	0.810	8.036	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
15	BIRC2	oncoprotein	12	0.745	8.711	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
16	BIRC3	oncoprotein	10	0.833	3.311	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
17	BIRC5	interactor	9	0.643	67.802	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
18	BIRC6	oncoprotein	5	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain SlyX (PF04102, IPR007236): SlyX UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
19	BIRC7	interactor	6	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20	BTK	suppressor	5	0.500	3.749	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21	CAPN1	interactor	13	0.487	165.437	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
22	CASP10	interactor	12	0.745	9.763	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
23	CASP2	suppressor	11	0.733	48.151	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
24	CASP3	interactor	30	0.217	661.649	Peptidase_C14 (PF00656, IPR011600): Caspase domain
25	CASP8	suppressor	20	0.374	125.358	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
26	CASP9	oncoprotein	15	0.524	64.085	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
27	CCDC8	interactor	15	0.176	154.093	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
28	CCT2	interactor	12	0.258	137.459	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
29	CCT5	interactor	10	0.444	40.687	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
30	CEP128	interactor	4	0.500	2.754	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31	CLSPN	interactor	3	0.333	4.136	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
32	CNDP2	suppressor	8	0.929	0.667	Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
33	COPS6	interactor	10	0.278	79.929	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
34	COX4I1	interactor	1	0	0	COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
35	CRYAB	oncoprotein	8	0.952	0.333	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
36	CTSA	interactor	5	0.600	41.106	Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
37	CUL4A	protein found in more fusions	9	0.250	65.491	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
38	CYFIP1	interactor	3	0.333	24.598	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
39	DFFA	suppressor	4	0.500	23.714	CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
40	DISC1	interactor	4	0.167	46.363	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
41	EEF2	interactor	14	0.275	197.352	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
42	EIF4H	interactor	6	0.600	67.060	eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43	ELAVL1	oncoprotein	24	0.178	1009.831	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44	EPHA7	oncoprotein	1	0	0	EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
45	ESR1	suppressor	21	0.168	515.976	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
46	ESRRB	suppressor	3	0	33.452	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
47	FBXW11	interactor	7	0.333	71.126	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
48	FYN	oncoprotein	10	0.278	104.215	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
49	GBP2	interactor	8	0.786	8.002	GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
50	GINS2	interactor	9	0.667	14.589	Sld5 (PF05916, IPR021151): GINS complex protein
51	GLI1	suppressor	3	0.667	1.778	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
52	GNA11	oncoprotein	6	0.400	18.351	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
53	GNAI1	oncoprotein	13	0.359	61.178	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
54	GNAI2	oncoprotein	18	0.235	131.304	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
55	GNAI3	interactor	17	0.287	225.048	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
56	GNAQ	oncoprotein	7	0.333	25.234	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
57	GNAS	oncoprotein	16	0.200	198.246	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
58	GNG10	interactor	5	0.700	1.404	G-gamma (PF00631, IPR015898, SM00224): GGL domain
59	GNG11	interactor	2	1.000	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
60	GNG12	interactor	4	0.500	1.862	G-gamma (PF00631, IPR015898, SM00224): GGL domain
61	GNG13	interactor	1	0	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
62	GNG2	interactor	18	0.183	173.129	G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein
63	GNG3	interactor	1	0	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
64	GNG4	interactor	5	0.700	1.404	G-gamma (PF00631, IPR015898, SM00224): GGL domain
65	GNG5	interactor	6	0.533	8.949	G-gamma (PF00631, IPR015898, SM00224): GGL domain
66	GNG7	interactor	4	1.000	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
67	GNG8	interactor	1	0	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
68	GNGT1	interactor	2	1.000	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
69	GNGT2	interactor	1	0	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
70	GNS	interactor	8	0.750	71.195	Sulfatase (PF00884, IPR000917): Sulfatase DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
71	GRK2	interactor	5	0.400	7.048	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
72	GZMB	interactor	5	0.700	2.274	Trypsin (PF00089, IPR001254, SM00020): Trypsin
73	HDAC4	oncoprotein	7	0.333	41.388	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
74	HDAC5	protein found in more fusions	10	0.389	45.451	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
75	HSPA5	oncoprotein	15	0.176	198.627	HSP70 (PF00012, IPR013126): Hsp70 protein
76	KALRN	oncoprotein	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain Spectrin (PF00435, IPR002017): Spectrin repeat UPF0302 (PF08864, IPR014963): UPF0302 domain CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase SH3_9 (PF14604, IPR001452): Variant SH3 domain PH_10 (PF15411): Pleckstrin homology domain SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
77	KCNJ3	interactor	2	1.000	0	IRK (PF01007, IPR016449): Inward rectifier potassium channel
78	MCF2	oncoprotein	2	0	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Spectrin (PF00435, IPR002017): Spectrin repeat CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
79	MCF2L	interactor	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Spectrin (PF00435, IPR002017): Spectrin repeat CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4771 (PF15995, IPR031936): Domain of unknown function (DUF4771)
80	MRGPRX1	interactor	4	0.500	1.567	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) RAMP4 (PF06624, IPR010580): Ribosome associated membrane protein RAMP4
81	MTNR1A	interactor	7	0.381	22.051	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
82	MTOR	oncoprotein	12	0.345	90.587	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
83	MVD	interactor	10	0.806	3.862	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
84	NCF2	interactor	4	1.000	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain TPR_16 (PF13432): Tetratricopeptide repeat
85	NOL11	interactor	2	0	36.190	NUC205 (PF08168, IPR012584): NUC205 domain DUF2779 (PF11074, IPR021301): Domain of unknown function(DUF2779)
86	NR3C1	protein found in more fusions	8	0.286	78.534	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
87	NTRK1	oncoprotein	31	0.133	1119.720	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
88	PAK1	oncoprotein	4	1.000	0	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
89	PAN2	interactor	12	0.212	107.945	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
90	PARP1	suppressor	14	0.179	157.950	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
91	PDCL	interactor	7	0.381	42.136	Phosducin (PF02114, IPR024253): Phosducin
92	PDLIM7	interactor	8	0.321	52.870	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
93	PEPD	interactor	10	0.667	22.782	AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
94	PIK3CG	oncoprotein	3	1.000	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
95	PIK3R5	oncoprotein	3	1.000	0	PI3K_1B_p101 (PF10486, IPR019522): Phosphoinositide 3-kinase gamma adapter protein p101 subunit
96	PLA2G4B	interactor	3	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
97	PLEKHG2	oncoprotein	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
98	PTGES3	interactor	8	0.238	100.759	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99	PTK2	protein found in more fusions	8	0.429	34.499	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
100	RACK1	suppressor	15	0.209	338.096	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
101	RADIL	interactor	2	1.000	0	DIL (PF01843, IPR018444, SM01132): DIL domain FHA (PF00498, IPR000253, SM00240): FHA domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
102	RAP1A	suppressor	8	0.286	87.573	Ras (PF00071, IPR001806, SM00173): Ras family
103	RASD1	interactor	2	1.000	0	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family Ras (PF00071, IPR001806, SM00173): Ras family
104	RASD2	interactor	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
105	RB1	suppressor	8	0.464	77.260	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
106	RGS6	interactor	1	0	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain G-gamma (PF00631, IPR015898, SM00224): GGL domain
107	RICTOR	interactor	7	0.667	6.626	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
108	ROCK1	interactor	4	0.167	21.251	FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
109	RPS6KA1	oncoprotein	14	0.440	306.220	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
110	RPTOR	protein found in more fusions	10	0.444	100.968	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
111	SAT1	protein found in more fusions	5	0.333	30.120	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
112	SP1	protein found in more fusions	9	0.321	72.012	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
113	SPAG1	interactor	1	0	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597) TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 TPR_19 (PF14559): Tetratricopeptide repeat
114	SPTAN1	oncoprotein	16	0.242	270.883	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
115	STAT1	suppressor	13	0.227	104.944	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
116	SVIL	interactor	10	0.333	47.818	Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
117	SYNPO	interactor	7	0.476	16.015	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
118	TBXA2R	interactor	8	0.476	10.107	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
119	TERF1	interactor	9	0.143	150.806	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
120	TNFRSF1A	oncoprotein	12	0.345	159.242	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
121	UBQLN1	protein found in more fusions	6	0.400	54.985	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
122	VCAM1	interactor	11	0.327	141.531	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
123	VCP	protein found in more fusions	26	0.170	624.965	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
124	VIM	suppressor	16	0.248	205.157	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
125	WDR26	interactor	4	0.500	2.952	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
126	XIAP	interactor	18	0.397	336.708	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
127	XPO1	interactor	22	0.199	483.769	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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