Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CUL4A, GNAS (from a repository: Wed Jul 24 10:14:48 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 341 The number (and %) of the onco-proteins 94 (27.57 %) The number (and %) of the tumor suppressors 36 (10.56 %) Total number of binary PPIs (saturation %) 3820 (6.59 %) The number (and %) of affected PPIs 348 (9.11 %) The number of possible different fusions 49 PPI diameter 4 PPI radius 2 The average degree of PPI 21.883 Assortativity coefficient -0.2716 The network average Clustering coefficient 0.523 The number (and %) of a zero Clustering coefficients 18 (5.28 %) The number (and %) of a zero Betweenness Centrality 48 (14.08 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CUL4A,GNAS	All fusions
Proteins found in more fusions	GRK5 (see 2 fusions); RUVBL1 (see 1 fusions); NTRK1/TFG (see 1 fusions); NPM1 (see 1 fusions); DCAF1 (see 1 fusions); COMMD1 (see 1 fusions); CUL1 (see 3 fusions); LGALS3BP (see 2 fusions); PCBD1 (see 1 fusions); RPS18/TUBG1 (see 1 fusions); OPTN (see 1 fusions); EWSR1 (see 1 fusions); PRDX1 (see 1 fusions); SAMHD1 (see 1 fusions); PCNA (see 1 fusions); DDX5 (see 1 fusions); RPLP2 (see 1 fusions); ARIH1 (see 4 fusions); CUL4A (see 4 fusions); VCP (see 4 fusions); HSP90AA1 (see 6 fusions); PRMT5 (see 1 fusions); GNAS (see 5 fusions); TLE2 (see 2 fusions); HSP90AB1 (see 3 fusions); COPS5/HNRNPH3 (see 3 fusions); HNRNPD (see 1 fusions); NF2 (see 1 fusions); TUBA1B/TUBA1C (see 11 fusions); HSP90AA1/BAG4 (see 1 fusions); DDB1 (see 4 fusions); NCL (see 4 fusions); HSPA8/HSPD1 (see 1 fusions); TUBG1 (see 1 fusions); EEF1A1 (see 6 fusions); NTRK1/RPL7A (see 1 fusions); CUL3 (see 1 fusions); MYC (see 2 fusions); UBE2E3 (see 5 fusions); COPS5 (see 1 fusions); UBC (see 7 fusions); HSP90AA1/TUBB (see 1 fusions); TP53 (see 3 fusions); PABPC1 (see 3 fusions); NFKB1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); RPTOR (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CUL4A	parental protein	279	0.072	39445.973	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
2	GNAS	parental protein	69	0.059	8939.206	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
3	ABCA10	interactor	2	1.000	0	ABC_tran (PF00005, IPR003439): ABC transporter DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 Wzy_C (PF04932, IPR007016): O-Antigen ligase ABC2_membrane_3 (PF12698): ABC-2 family transporter protein AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162) Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
4	ABCE1	interactor	21	0.289	515.143	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
5	ADCY2	interactor	1	0	0	DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053) HNOBA (PF07701, IPR011645): Heme NO binding associated Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain DUF3487 (PF11990, IPR021877): Protein of unknown function (DUF3487) DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131) AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
6	ADCY6	interactor	1	0	0	DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053) HNOBA (PF07701, IPR011645): Heme NO binding associated PRA1 (PF03208, IPR004895): PRA1 family protein DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207) Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
7	ADRB2	interactor	32	0.140	468.610	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8	AK9	oncoprotein	2	1.000	0	ADK (PF00406, IPR000850): Adenylate kinase Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase Josephin (PF02099, IPR006155): Josephin MAS20 (PF02064, IPR002056): MAS20 protein import receptor YHS (PF04945, IPR007029): YHS domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508) AAA_14 (PF13173): AAA domain AAA_16 (PF13191): AAA ATPase domain AAA_17 (PF13207): AAA domain AAA_18 (PF13238): AAA domain
9	AMBRA1	interactor	17	0.441	29.993	Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Spt20 (PF12090, IPR021950): Spt20 family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10	ANAPC5	interactor	4	0.667	2.470	TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
11	ARIH1	protein found in more fusions	7	0.867	0.257	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain Med14 (PF08638, IPR013947): Mediator complex subunit MED14 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
12	ARMCX3	oncoprotein	2	0	3.872	Arm_2 (PF04826, IPR006911): Armadillo-like Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
13	ASB4	interactor	7	0.524	2.294	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
14	AVPR2	interactor	5	0.300	19.822	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
15	AXIN1	suppressor	9	0.357	37.303	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
16	BAG4	protein found in more fusions	14	0.791	8.852	BAG (PF02179, IPR003103, SM00264): BAG domain DMP12 (PF16779, IPR031891): DNA-mimic protein
17	BANF1	interactor	12	0.327	23.413	BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
18	BRWD1	interactor	6	0.667	3.775	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
19	BTRC	oncoprotein	35	0.291	288.734	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
20	C1QBP	interactor	30	0.423	498.829	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
21	CA2	interactor	6	0.867	0.500	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
22	CALM1	interactor	29	0.246	514.311	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23	CAND1	interactor	123	0.190	2015.636	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
24	CARNMT1	interactor	2	1.000	0	N2227 (PF07942, IPR012901): N2227-like protein RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
25	CAST	oncoprotein	3	1.000	0	Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain Calpain_inhib (PF00748, IPR001259): Calpain inhibitor Maf_N (PF08383, IPR013592): Maf N-terminal region
26	CAT	suppressor	7	0.600	17.738	Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
27	CCDC8	interactor	55	0.205	855.209	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
28	CCNG1	oncoprotein	4	1.000	0	Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
29	CCT5	interactor	26	0.289	150.703	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
30	CDC5L	interactor	55	0.233	976.012	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
31	CDKN1A	suppressor	31	0.344	258.610	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
32	CDKN1B	suppressor	16	0.583	22.464	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
33	CDT1	oncoprotein	15	0.438	33.849	CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
34	CDY2A	interactor	1	0	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase Mrr_cat (PF04471, IPR007560): Restriction endonuclease DUF2607 (PF10795, IPR019731): Protein of unknown function (DUF2607)
35	CDY2B	interactor	1	0	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase Mrr_cat (PF04471, IPR007560): Restriction endonuclease DUF2607 (PF10795, IPR019731): Protein of unknown function (DUF2607)
36	CENPA	interactor	13	0.318	19.311	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
37	CHEK1	suppressor	15	0.524	16.474	Pkinase (PF00069, IPR000719): Protein kinase domain
38	CHEK2	suppressor	10	0.472	117.234	FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain
39	CLCN1	interactor	4	1.000	0	CBS (PF00571, IPR000644, SM00116): CBS domain Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
40	COMMD1	protein found in more fusions	9	0.679	3.412	COMMD1_N (PF17221): COMMD1 N-terminal domain COMM_domain (PF07258): COMM domain
41	COPS2	suppressor	32	0.502	123.673	YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
42	COPS3	interactor	38	0.496	126.513	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain
43	COPS4	interactor	37	0.511	133.439	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
44	COPS5	protein found in more fusions	158	0.153	4567.346	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
45	COPS6	interactor	109	0.195	1927.898	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
46	COPS7A	interactor	32	0.554	85.043	PCI (PF01399, IPR000717, SM00088): PCI domain
47	COPS7B	interactor	21	0.867	4.643	PCI (PF01399, IPR000717, SM00088): PCI domain
48	COPS8	interactor	26	0.703	23.494	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
49	COPS9	interactor	15	0.829	4.312	MYEOV2 (PF15004, IPR029391): Myeloma-overexpressed-like
50	CPT2	interactor	1	0	0	Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
51	CRBN	interactor	12	0.576	11.099	LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
52	CRHR1	interactor	2	1.000	0	7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family) HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
53	CSN1S1	interactor	4	1.000	0	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger Gly-rich_Ago1 (PF12764, IPR024357): Glycine-rich region of argonaut
54	CTNNB1	oncoprotein	35	0.269	325.644	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
55	CUL1	suppressor	158	0.146	4473.293	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
56	CUL3	protein found in more fusions	162	0.142	5569.699	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
57	CUL4B	oncoprotein	156	0.131	5680.776	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
58	CUL5	suppressor	137	0.168	3137.526	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
59	DAB2IP	suppressor	7	0.524	5.538	C2 (PF00168, IPR000008, SM00239): C2 domain PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
60	DBN1	oncoprotein	15	0.305	131.098	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
61	DCAF1	protein found in more fusions	33	0.435	126.153	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
62	DCAF10	interactor	6	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
63	DCAF11	interactor	15	0.848	3.077	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
64	DCAF12	interactor	5	1.000	0	ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
65	DCAF12L2	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
66	DCAF15	interactor	3	1.000	0	DCAF15_WD40 (PF14939, IPR032734): DDB1-and CUL4-substrate receptor 15, WD repeat
67	DCAF16	interactor	6	1.000	0	DCA16 (PF15349, IPR028216): DDB1- and CUL4-associated factor 16
68	DCAF17	interactor	5	1.000	0	DCAF17 (PF15802, IPR031620): DDB1- and CUL4-associated factor 17
69	DCAF4	interactor	9	0.889	1.315	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4221 (PF13970, IPR025316): Domain of unknown function (DUF4221)
70	DCAF4L1	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat zf-CHC2 (PF01807, IPR002694): CHC2 zinc finger ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
71	DCAF4L2	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
72	DCAF5	interactor	7	0.524	6.987	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2634 (PF10934, IPR020288): Protein of unknown function (DUF2634) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
73	DCAF6	interactor	6	1.000	0	Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ATAD4 (PF15321, IPR028237): ATPase family AAA domain containing 4 MRI (PF15325, IPR028278): Modulator of retrovirus infection WD40_like (PF17005, IPR031544): WD40-like domain
74	DCAF7	interactor	8	0.536	5.279	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
75	DCAF8	interactor	15	0.629	32.188	DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
76	DCST1	interactor	1	0	0	DC_STAMP (PF07782, IPR012858): DC-STAMP-like protein zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
77	DCUN1D1	interactor	90	0.247	851.085	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
78	DCUN1D2	interactor	9	0.889	0.718	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
79	DCUN1D3	suppressor	8	0.893	0.384	Cullin_binding (PF03556, IPR005176): Cullin binding
80	DCUN1D4	interactor	8	0.893	0.384	Cullin_binding (PF03556, IPR005176): Cullin binding
81	DCUN1D5	interactor	9	0.889	0.693	Cullin_binding (PF03556, IPR005176): Cullin binding
82	DDA1	interactor	38	0.309	275.410	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
83	DDB1	protein found in more fusions	105	0.138	3729.473	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
84	DDB2	suppressor	25	0.551	49.441	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
85	DDIT4	interactor	3	1.000	0	RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
86	DDX21	interactor	12	0.364	23.146	CRT10 (PF08728, IPR014839): CRT10 DEAD (PF00270, IPR011545): DEAD/DEAH box helicase GUCT (PF08152, IPR012562): GUCT (NUC152) domain Sulfatase (PF00884, IPR000917): Sulfatase MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
87	DDX5	oncoprotein	34	0.487	71.434	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
88	DET1	interactor	9	0.750	2.669	Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
89	DHX15	interactor	27	0.501	55.097	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
90	DHX9	oncoprotein	32	0.478	158.183	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
91	DICER1	suppressor	10	0.611	3.859	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
92	DIS3	interactor	5	0.600	29.137	RNB (PF00773, SM00955): RNB domain rve (PF00665, IPR001584): Integrase core domain PIN_4 (PF13638, IPR002716): PIN domain Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain Rrp44_S1 (PF17215): S1 domain
93	DLC1	suppressor	5	1.000	0	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) START (PF01852, IPR002913, SM00234): START domain DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
94	DNAJC10	interactor	15	0.733	10.313	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
95	DNAJC7	interactor	17	0.478	186.329	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
96	DNMT3B	suppressor	9	0.556	4.973	DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase PWWP (PF00855, IPR000313, SM00293): PWWP domain
97	DPPA4	interactor	10	0.444	9.854	Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family DCR (PF14047, IPR025891): Dppa2/4 conserved region Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
98	DTL	interactor	21	0.457	55.176	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
99	EED	suppressor	55	0.194	470.559	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
100	EEF1A1	suppressor	56	0.352	905.958	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
101	EEF1A2	oncoprotein	16	0.725	2.924	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
102	EGFR	oncoprotein	43	0.221	760.593	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
103	EIF4H	interactor	9	0.361	75.749	eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
104	ELMSAN1	interactor	2	1.000	0	ELM2 (PF01448, IPR000949): ELM2 domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
105	EMD	interactor	23	0.355	106.341	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
106	EML2	interactor	2	0	4.443	CPSF_A (PF03178, IPR004871): CPSF A subunit region HELP (PF03451, IPR005108): HELP motif SlyX (PF04102, IPR007236): SlyX WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain KAAG1 (PF15354, IPR029407): Kidney-associated antigen 1
107	ENO1	oncoprotein	22	0.519	97.163	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
108	ERCC6	oncoprotein	17	0.515	18.329	Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
109	ERCC8	oncoprotein	26	0.517	54.153	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
110	EWSR1	oncoprotein	52	0.313	662.707	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
111	FBXW5	interactor	9	0.556	19.635	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like
112	FBXW8	interactor	12	0.652	13.175	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
113	FLNA	suppressor	20	0.358	227.007	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
114	FSCN1	oncoprotein	6	0.667	12.748	Fascin (PF06268, IPR022768): Fascin domain
115	FUS	suppressor	54	0.384	863.712	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
116	GIPC1	interactor	3	0.667	4.422	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
117	GLMN	oncoprotein	6	0.867	0.417	Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
118	GNA11	oncoprotein	6	0.467	6.313	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
119	GNA12	oncoprotein	5	0.200	28.461	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
120	GNAL	interactor	1	0	0	BEX (PF04538, IPR021156): Brain expressed X-linked like family G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
121	GNAQ	oncoprotein	14	0.165	265.423	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
122	GNB1	interactor	19	0.211	974.245	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
123	GNB2	interactor	19	0.216	996.147	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CALM_bind (PF16025): Calcium-dependent calmodulin binding WD40_like (PF17005, IPR031544): WD40-like domain
124	GNB3	interactor	8	0	372.463	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
125	GNB4	interactor	12	0.227	538.317	Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
126	GNB5	interactor	8	0.179	254.801	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
127	GNG10	interactor	5	0.300	9.485	G-gamma (PF00631, IPR015898, SM00224): GGL domain
128	GNG2	interactor	12	0.197	89.230	G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein
129	GNG4	interactor	6	0.200	24.634	G-gamma (PF00631, IPR015898, SM00224): GGL domain
130	GNG5	interactor	7	0.238	29.217	G-gamma (PF00631, IPR015898, SM00224): GGL domain
131	GPS1	interactor	30	0.526	111.285	RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain
132	GRK5	protein found in more fusions	29	0.193	621.339	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
133	GRWD1	interactor	17	0.566	26.109	Voldacs (PF03517): Regulator of volume decrease after cellular swelling WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
134	H2AFV	interactor	10	0.644	2.162	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
135	HAX1	interactor	14	0.385	224.657	Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
136	HERC2	interactor	9	0.429	22.742	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain MIB_HERC2 (PF06701, IPR010606): Mib_herc2 RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
137	HIST1H1A	interactor	16	0.317	30.671	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
138	HIST1H1C	oncoprotein	22	0.519	39.167	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
139	HIST1H2AB	interactor	13	0.603	9.022	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
140	HIST1H2AE	interactor	9	0.694	7.462	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
141	HIST1H2AG	interactor	11	0.691	4.094	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
142	HIST1H2AI	interactor	8	0.786	0.161	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
143	HIST1H2AJ	interactor	8	0.786	0.161	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
144	HIST1H2AK	interactor	8	0.786	0.161	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
145	HIST1H2AL	interactor	8	0.786	0.161	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
146	HIST1H2AM	interactor	8	0.786	0.161	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
147	HIST1H2BG	oncoprotein	9	0.361	47.914	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
148	HIST1H3A	interactor	25	0.217	160.634	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
149	HLA-A	oncoprotein	8	0.464	38.734	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
150	HNRNPA2B1	oncoprotein	31	0.561	55.212	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
151	HNRNPAB	interactor	21	0.676	18.762	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain GRP (PF07172, IPR010800): Glycine rich protein family NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
152	HNRNPD	oncoprotein	38	0.485	131.657	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
153	HNRNPDL	interactor	28	0.635	84.870	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
154	HNRNPF	interactor	33	0.583	58.183	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
155	HNRNPH1	oncoprotein	36	0.556	66.873	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
156	HNRNPH3	protein found in more fusions	28	0.658	31.096	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
157	HNRNPUL1	interactor	22	0.738	43.969	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
158	HOXA9	oncoprotein	3	1.000	0	Hox9_act (PF04617, IPR006711): Hox9 activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
159	HOXB4	interactor	3	1.000	0	DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
160	HSP90AA1	oncoprotein	73	0.275	1488.401	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
161	HSP90AB1	oncoprotein	47	0.394	269.058	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
162	HSP90B1	suppressor	21	0.471	74.840	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
163	HSPA1A	interactor	34	0.551	86.466	HSP70 (PF00012, IPR013126): Hsp70 protein
164	HSPA1B	interactor	17	0.544	29.897	HSP70 (PF00012, IPR013126): Hsp70 protein
165	HSPA1L	interactor	24	0.489	368.996	HSP70 (PF00012, IPR013126): Hsp70 protein
166	HSPA5	oncoprotein	61	0.381	592.873	HSP70 (PF00012, IPR013126): Hsp70 protein
167	HSPA7	interactor	13	0.667	2.104	NA
168	HSPA8	oncoprotein	53	0.368	480.462	HSP70 (PF00012, IPR013126): Hsp70 protein
169	HSPA9	oncoprotein	36	0.383	269.118	HSP70 (PF00012, IPR013126): Hsp70 protein
170	HSPD1	suppressor	35	0.418	179.648	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
171	IARS	interactor	15	0.419	38.824	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
172	IFI16	suppressor	12	0.212	59.782	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
173	IGF2BP1	oncoprotein	15	0.438	18.182	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
174	IGHV3OR15-7	interactor	8	0.964	0.018	V-set (PF07686, IPR013106): Immunoglobulin V-set domain
175	IP6K1	interactor	5	0.900	0.095	IPK (PF03770, IPR005522): Inositol polyphosphate kinase SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
176	JAK3	oncoprotein	5	0.200	48.317	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
177	KAT14	oncoprotein	4	1.000	0	Acetyltransf_10 (PF13673, IPR000182): Acetyltransferase (GNAT) domain
178	KAT2A	interactor	16	0.324	46.492	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
179	KLHL9	interactor	6	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
180	KRT1	interactor	18	0.660	17.186	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
181	KRT10	interactor	14	0.747	10.636	Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
182	KRT2	interactor	19	0.538	28.066	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
183	KRT24	interactor	9	0.972	0.018	Filament (PF00038, IPR001664): Intermediate filament protein DUF4766 (PF15973, IPR031903): Domain of unknown function (DUF4766)
184	KRT75	interactor	10	0.933	0.071	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
185	KRT76	interactor	7	0.905	0.053	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
186	KRT9	interactor	13	0.705	10.636	Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
187	LAMTOR1	interactor	2	0	3.996	LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
188	LGALS3BP	oncoprotein	27	0.637	44.731	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
189	LOC285556	interactor	1	0	0	Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain DUF4585 (PF15232, IPR027838): Domain of unknown function (DUF4585)
190	LRWD1	interactor	6	0.600	3.057	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
191	MAGED2	interactor	20	0.495	185.388	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
192	MAP4	oncoprotein	10	0.467	11.180	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
193	MCM10	interactor	9	0.472	9.240	Mcm10 (PF09332, IPR015411): Mcm10 replication factor zf-primase (PF09329, IPR015408): Primase zinc finger AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
194	MCM2	oncoprotein	103	0.158	2406.077	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
195	MDM2	oncoprotein	51	0.269	1000.948	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
196	METAP2	oncoprotein	4	0.667	0.425	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
197	MRPS11	interactor	7	0.619	5.571	Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
198	MTM1	interactor	1	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain 3-PAP (PF12578, IPR022587): Myotubularin-associated protein
199	MYB	oncoprotein	9	0.417	7.384	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
200	MYC	oncoprotein	44	0.196	793.150	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
201	MYH9	suppressor	23	0.332	612.877	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
202	NACC1	interactor	4	0.333	2.535	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain
203	NANOG	interactor	19	0.183	55.482	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
204	NCL	protein found in more fusions	39	0.448	126.493	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
205	NEDD8	interactor	98	0.209	1044.368	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
206	NF2	suppressor	25	0.149	670.346	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
207	NFKB1	suppressor	17	0.558	24.264	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
208	NPM1	suppressor	64	0.352	931.779	Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
209	NTRK1	oncoprotein	117	0.166	5202.526	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
210	NUCB1	interactor	5	0.200	38.414	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
211	NUCB2	interactor	3	0.667	5.098	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like Histone_HNS (PF00816, IPR001801): H-NS histone family Peptidase_U57 (PF05582, IPR008764): YabG peptidase U57 Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
212	NUP43	interactor	4	0.667	1.206	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
213	NXPH3	interactor	2	1.000	0	Neurexophilin (PF06312, IPR026845): Neurexophilin
214	OCIAD1	interactor	7	0.333	13.279	OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
215	OPTN	protein found in more fusions	5	0.333	10.364	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
216	OTULIN	interactor	3	1.000	0	Peptidase_C101 (PF16218, IPR023235): Peptidase family C101
217	PABPC1	oncoprotein	33	0.524	189.758	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
218	PABPC4	interactor	21	0.610	32.479	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
219	PAICS	interactor	10	0.333	64.493	AIRC (PF00731, IPR000031, SM01001): AIR carboxylase SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
220	PANX1	interactor	2	0	10.532	Innexin (PF00876, IPR000990): Innexin Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
221	PCBD1	protein found in more fusions	10	0.778	1.616	Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
222	PCK1	interactor	15	0.219	140.318	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
223	PCNA	oncoprotein	27	0.418	72.598	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
224	PFAS	interactor	8	0.429	16.266	AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
225	PHIP	oncoprotein	9	0.528	7.782	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) E7 (PF00527, IPR000148): E7 protein, Early protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
226	POC1B	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
227	POU5F1	oncoprotein	30	0.175	136.642	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
228	PPP2R1A	oncoprotein	23	0.451	46.763	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
229	PRDX1	oncoprotein	22	0.443	195.496	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
230	PRMT5	protein found in more fusions	19	0.333	162.929	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
231	PSMC6	interactor	13	0.409	14.206	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
232	PTGIR	interactor	4	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
233	PTGS2	oncoprotein	12	0.564	77.541	An_peroxidase (PF03098, IPR002007): Animal haem peroxidase EGF (PF00008, IPR000742, SM00181): EGF-like domain
234	PWP1	interactor	13	0.667	9.361	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
235	PYGO2	interactor	9	0.607	7.017	PHD (PF00628, IPR019787, SM00249): PHD-finger
236	QPCT	interactor	9	0.944	0.043	Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
237	RAD21	oncoprotein	25	0.427	37.093	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
238	RAG1	interactor	8	0.619	2.719	zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-RAG1 (PF10426, IPR019485): Recombination-activating protein 1 zinc-finger domain RAG1_imp_bd (PF12560): RAG1 importin binding RAG1 (PF12940, IPR024627): Recombination-activation protein 1 (RAG1), recombinase
239	RASSF1	suppressor	11	0.600	7.896	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
240	RBBP4	oncoprotein	17	0.426	49.804	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
241	RBBP5	oncoprotein	12	0.455	16.372	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
242	RBBP7	suppressor	14	0.385	40.167	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
243	RBX1	oncoprotein	54	0.274	526.264	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
244	RFWD2	suppressor	28	0.587	37.368	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain
245	RGS12	interactor	2	1.000	0	PT-HINT (PF07591): Pretoxin HINT domain GoLoco (PF02188, IPR003109, SM00390): GoLoco motif PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain RGS12_us2 (PF16611): Unstructured region between RBD and GoLoco RGS12_usC (PF16612): C-terminal unstructured region of RGS12 RGS12_us1 (PF16613): Unstructured region of RGS12
246	RGS2	oncoprotein	6	0.333	67.030	RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
247	RIC8B	interactor	3	0.667	3.925	Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
248	RNF7	oncoprotein	15	0.495	19.883	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
249	RPL10A	interactor	38	0.624	64.902	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
250	RPL11	suppressor	39	0.640	53.506	Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
251	RPL15	interactor	38	0.670	52.000	Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
252	RPL19	interactor	31	0.740	23.776	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
253	RPL22	oncoprotein	36	0.546	100.952	Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
254	RPL23A	interactor	36	0.678	40.521	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23 Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
255	RPL26	oncoprotein	16	0.792	2.882	TP2 (PF01254, IPR000678): Nuclear transition protein 2 Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
256	RPL38	interactor	31	0.660	49.779	Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
257	RPL4	interactor	45	0.522	227.710	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
258	RPL7A	protein found in more fusions	33	0.621	45.851	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
259	RPL7AP27	interactor	10	0.800	0.532	NA
260	RPLP1	interactor	30	0.778	30.683	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
261	RPLP2	protein found in more fusions	35	0.690	26.988	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
262	RPS14	interactor	39	0.595	96.503	Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
263	RPS15A	interactor	39	0.560	101.048	Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
264	RPS18	protein found in more fusions	32	0.675	45.411	Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
265	RPS2	interactor	44	0.502	655.657	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
266	RPS20	interactor	33	0.706	32.558	Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
267	RPS3	interactor	46	0.500	177.257	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
268	RPTOR	protein found in more fusions	9	0.464	77.264	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
269	RUVBL1	oncoprotein	25	0.373	200.940	TIP49 (PF06068, IPR010339): TIP49 C-terminus
270	SALL2	suppressor	7	0.619	2.793	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
271	SAMHD1	protein found in more fusions	14	0.603	11.316	HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
272	SAP130	interactor	10	0.511	7.151	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
273	SCAF11	interactor	8	0.393	7.658	DUF566 (PF04484, IPR007573): Family of unknown function (DUF566) Phage_XkdX (PF09693, IPR010022): Phage uncharacterised protein (Phage_XkdX) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
274	SDHA	suppressor	12	0.909	0.557	FAD_binding_2 (PF00890, IPR003953): FAD binding domain Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
275	SENP8	interactor	6	0.800	0.517	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
276	SF3B3	interactor	23	0.494	42.375	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
277	SFXN1	interactor	4	0.500	1.591	Mtc (PF03820, IPR004686): Tricarboxylate carrier
278	SH3RF2	interactor	2	1.000	0	SH3_2 (PF07653, IPR011511): Variant SH3 domain TUDOR (PF00567, IPR002999, SM00333): Tudor domain UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547 SH3_1 (PF00018, IPR001452, SM00326): SH3 domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger SH3_9 (PF14604, IPR001452): Variant SH3 domain
279	SHMT2	interactor	15	0.362	280.125	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
280	SKP1	oncoprotein	37	0.338	192.072	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
281	SKP2	suppressor	22	0.468	48.355	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
282	SLA	interactor	2	0	1.223	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
283	SLC25A12	interactor	3	0	16.440	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
284	SLC25A22	interactor	5	0.500	4.417	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
285	SLC25A5	interactor	30	0.630	48.032	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
286	SLC25A6	interactor	14	0.407	38.832	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
287	SNRNP40	interactor	7	0.524	6.401	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
288	SNRNP70	interactor	24	0.562	40.545	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
289	SNRPA	interactor	18	0.640	12.967	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
290	SNRPB	interactor	13	0.756	6.178	LSM (PF01423, IPR001163): LSM domain
291	SNRPD1	interactor	31	0.484	76.793	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain
292	SNRPD3	interactor	20	0.563	25.288	LSM (PF01423, IPR001163): LSM domain
293	SNRPE	interactor	17	0.699	14.030	LSM (PF01423, IPR001163): LSM domain
294	SNX13	interactor	1	0	0	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Nexin_C (PF08628, IPR013937): Sorting nexin C terminal PX (PF00787, IPR001683, SM00312): PX domain PXA (PF02194, IPR003114, SM00313): PXA domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3 DUF2314 (PF10077, IPR018756): Uncharacterized protein conserved in bacteria (DUF2314)
295	SRSF3	oncoprotein	20	0.516	79.784	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
296	SSBP1	interactor	23	0.506	42.697	SSB (PF00436, IPR000424): Single-strand binding protein family
297	SUGT1	interactor	11	0.455	15.972	CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
298	SYNM	suppressor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
299	SYNPO	interactor	7	0.571	3.891	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
300	TAF15	oncoprotein	16	0.625	8.977	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Presenilin (PF01080, IPR001108): Presenilin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
301	TBXA2R	interactor	9	0.357	66.471	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
302	TCHP	suppressor	2	1.000	0	TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term TPH (PF13868): Trichohyalin-plectin-homology domain PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
303	TFG	oncoprotein	22	0.605	25.099	ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2 MucBP (PF06458, IPR009459): MucBP domain PB1 (PF00564, IPR000270, SM00666): PB1 domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
304	THOC2	interactor	6	0.467	22.277	Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
305	TIA1	interactor	13	0.564	14.310	Calcipressin (PF04847, IPR006931): Calcipressin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
306	TIAL1	interactor	14	0.560	14.496	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
307	TLE2	protein found in more fusions	3	1.000	0	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
308	TOR1AIP2	interactor	10	0.889	0.622	LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
309	TP53	suppressor	94	0.172	2101.265	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
310	TRO	interactor	4	0.167	14.118	MAGE (PF01454, IPR002190): MAGE family DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533) AP3D1 (PF06375): AP-3 complex subunit delta-1
311	TRPC4AP	interactor	7	0.810	1.307	Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
312	TTC1	interactor	8	0.286	98.751	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
313	TUBA1B	protein found in more fusions	11	0.400	14.559	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
314	TUBA1C	protein found in more fusions	38	0.401	670.012	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
315	TUBA4A	interactor	29	0.490	311.095	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
316	TUBA4B	interactor	10	0.822	0.823	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
317	TUBB	protein found in more fusions	44	0.420	217.969	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
318	TUBB1	interactor	12	0.545	131.810	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
319	TUBB4B	interactor	33	0.485	79.185	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
320	TUBG1	protein found in more fusions	48	0.281	361.959	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
321	UBC	protein found in more fusions	78	0.222	2263.776	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
322	UBE2E3	protein found in more fusions	11	0.689	4.758	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
323	UBXN7	interactor	16	0.558	24.607	UBX (PF00789, IPR001012, SM00166): UBX domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
324	UNK	interactor	28	0.217	208.319	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
325	USP7	oncoprotein	32	0.303	395.197	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
326	VCP	protein found in more fusions	60	0.251	942.995	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
327	VIPR1	interactor	2	1.000	0	7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family) HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
328	WDR26	interactor	11	0.436	82.852	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
329	WDR5	interactor	28	0.275	229.834	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
330	WDR5B	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
331	WDR61	interactor	9	0.472	14.107	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
332	WDR76	interactor	12	0.379	27.921	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat SPATIAL (PF15256): SPATIAL
333	WDR82	oncoprotein	11	0.527	14.678	MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
334	WDTC1	interactor	7	0.476	14.487	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
335	WSB1	interactor	4	1.000	0	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SOCS_box (PF07525, IPR001496): SOCS box
336	WSB2	interactor	4	0.833	0.120	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 SOCS_box (PF07525, IPR001496): SOCS box
337	XPO1	interactor	69	0.109	2747.603	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
338	XXYLT1	oncoprotein	2	0	4.939	Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
339	YBEY	interactor	3	0.333	5.208	UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
340	ZNF407	interactor	2	1.000	0	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zinc_ribbon_4 (PF13717): zinc-ribbon domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
341	ZNF525	interactor	2	1.000	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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