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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GCLC, PDSS1 (from a repository: Mon May 27 12:31:09 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)14 (17.95 %)
The number (and %) of affected PPIs11 (78.57 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI1.846
Assortativity coefficient-0.0580
The network average Clustering coefficient0.157
The number (and %) of a zero Clustering coefficients10 (76.92 %)
The number (and %) of a zero Betweenness Centrality11 (84.62 %)


List of the fusions

PPI for parental proteins: PDSS1,GCLC All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PDSS1parental protein306.000polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
2 GCLCparental protein80.03654.000GCS (PF03074, IPR004308): Glutamate-cysteine ligase
3 ACAD9interactor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 AGLinteractor100GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
5 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
6 DHRS11interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
NmrA (PF05368, IPR008030): NmrA-like family
7 DPH5interactor100TP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) Methylases
8 ELAVL1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 GCLMinteractor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
10 NECTIN4oncoprotein100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
11 PAXIP1interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
12 PPIDinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
13 TNFSF13Boncoprotein200TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family

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