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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HOXB13, PCDH17 (from a repository: Thu Aug 15 19:47:00 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins6 (30.00 %)
The number (and %) of the tumor suppressors3 (15.00 %)
Total number of binary PPIs (saturation %)31 (16.32 %)
The number (and %) of affected PPIs18 (58.06 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.300
Assortativity coefficient0.0324
The network average Clustering coefficient0.377
The number (and %) of a zero Clustering coefficients11 (55.00 %)
The number (and %) of a zero Betweenness Centrality17 (85.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HOXB13,PCDH17 All fusions
Proteins found in more fusions POU2F1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HOXB13parental protein150.048197.000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
2 PCDH17parental protein306.000Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
3 ALX4interactor31.0000OAR (PF03826, IPR003654): OAR domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
4 EEDsuppressor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 ELK1oncoprotein200Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
6 FOXA2suppressor100Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
7 FOXC2oncoprotein31.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 FOXE1oncoprotein21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
9 FOXF1interactor200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
10 FOXG1oncoprotein100SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
11 FOXS1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 HOXD4interactor100SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
13 IRF4suppressor100IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
14 NR1H2oncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 POU2F1protein found in more fusions50.5003.000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
16 RNF2interactor31.0000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
17 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
18 UBQLN4interactor200CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
19 ZNF490interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
20 ZP3interactor100MDMPI_C (PF07398, IPR010872): MDMPI C-terminal domain
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain

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