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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ETAA1, NPTN (from a repository: Tue Aug 6 08:45:35 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins2 (13.33 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)21 (20.00 %)
The number (and %) of affected PPIs13 (61.90 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.133
Assortativity coefficient-0.3050
The network average Clustering coefficient0.138
The number (and %) of a zero Clustering coefficients11 (73.33 %)
The number (and %) of a zero Betweenness Centrality10 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ETAA1,NPTN All fusions
Proteins found in more fusions LGALS3 (see 2 fusions); NPTN/NDUFV2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ETAA1parental protein5092.000ETAA1 (PF15350, IPR029406): Ewing's tumour-associated antigen 1 homologue
2 NPTNparental protein80.071117.000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
3 FBXO6interactor30.33396.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
4 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
5 HIST1H4Ainteractor2090.000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
6 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
7 NDUFV2protein found in more fusions1002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
8 NIT2suppressor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
9 SLC25A5interactor30.6677.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
10 SUPT16Hinteractor200Nop14 (PF04147, IPR007276): Nop14-like family
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
11 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
12 TARSL2interactor100HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
13 UBXN1interactor200Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
14 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain
15 ZBTB48suppressor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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