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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NDUFV2, NPTN (from a repository: Fri Jul 19 11:10:42 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins6 (9.68 %)
The number (and %) of the tumor suppressors7 (11.29 %)
Total number of binary PPIs (saturation %)384 (20.31 %)
The number (and %) of affected PPIs61 (15.89 %)
The number of possible different fusions5
PPI diameter3
PPI radius2
The average degree of PPI12.097
Assortativity coefficient-0.1848
The network average Clustering coefficient0.491
The number (and %) of a zero Clustering coefficients12 (19.35 %)
The number (and %) of a zero Betweenness Centrality11 (17.74 %)


List of the fusions

PPI for parental proteins: NPTN,NDUFV2 All fusions
Proteins found in more fusions NDUFS3 (see 1 fusions); LGALS3 (see 2 fusions); KAT5 (see 3 fusions); NPTN/NDUFV2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 NPTNparental protein80.071339.760C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 NDUFV2parental protein540.2071921.7152Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
3 C15orf48interactor200.64722.739B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 CRMP1interactor200Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
5 FBXO6interactor110.27357.279FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
6 FN1oncoprotein120.27389.690fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
7 FOXB1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
8 FOXG1oncoprotein100SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
9 GOLT1Binteractor230.58952.567Got1 (PF04178, IPR007305): Got1/Sft2-like family
10 KAT5suppressor200MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
11 LGALS3oncoprotein50.5007.167Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
12 MMGT1interactor90.7504.112MMgT (PF10270, IPR018937): Membrane magnesium transporter
13 MT-CO2interactor50.7001.333COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
14 MT-ND5interactor90.9720.100NADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
15 ND1interactor80.9640.100NA
16 NDUFA10interactor120.7732.276dNK (PF01712, IPR002624): Deoxynucleoside kinase
17 NDUFA11interactor200.7379.9027kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
18 NDUFA12interactor310.53572.410NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
19 NDUFA13interactor140.9011.263GRIM-19 (PF06212, IPR009346): GRIM-19 protein
20 NDUFA2interactor180.65416.604L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
21 NDUFA4interactor220.67115.148B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
22 NDUFA6interactor110.7272.276Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
23 NDUFA8interactor210.70017.990CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
24 NDUFA9interactor290.57663.302Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
25 NDUFB10interactor110.8911.422NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
26 NDUFB4interactor150.7816.445NDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
27 NDUFS1interactor280.54277.635NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
28 NDUFS2interactor220.70124.427Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
29 NDUFS3protein found in more fusions310.50896.670Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
30 NDUFS4interactor250.63376.880ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
31 NDUFS5interactor250.63728.688Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
32 NDUFS6interactor240.64539.959Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
33 NDUFS7interactor190.81010.760Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
34 NDUFS8interactor220.64928.886Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
35 NDUFV1interactor290.55792.267Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
36 NDUFV3interactor140.8353.355DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
37 NIT2suppressor204.324CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
38 NOTCH2suppressor30.6670.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
39 NPC2interactor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
40 PCYOX1interactor100Prenylcys_lyase (PF07156, IPR010795): Prenylcysteine lyase
NAD_binding_8 (PF13450): NAD(P)-binding Rossmann-like domain
41 PITRM1interactor40.6671.667M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
42 RAB7Asuppressor100.40047.419Ras (PF00071, IPR001806, SM00173): Ras family
43 RASSF1suppressor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
44 SDHAsuppressor110.50919.404FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
45 SDHBsuppressor150.55219.830Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
46 SEPT9oncoprotein60.26732.719Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
47 SLC25A3interactor120.50016.506Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
48 SLC25A5interactor50.30013.274Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
49 SP110oncoprotein100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
50 SUCLG2interactor40.5003.130ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
51 SURF1interactor50.8000.733SURF1 (PF02104, IPR002994): SURF1 family
52 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
53 SVILinteractor21.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
54 SYNCRIPinteractor30.3332.975RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
55 TCTN3interactor120.45583.263DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
56 TJP1interactor40.6671.451DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
57 TMED9interactor30.6670.772EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
58 TPI1interactor50.50063.133TIM (PF00121, IPR000652): Triosephosphate isomerase
59 UBXN1interactor200Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
60 UQCRC1interactor70.7622.281Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
61 VAPAinteractor220.51556.547DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
62 VMA21interactor306.944VMA21 (PF09446, IPR019013): VMA21-like domain

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