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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TPK1, CYCS (from a repository: Sun Oct 21 08:52:57 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins9 (18.37 %)
The number (and %) of the tumor suppressors5 (10.20 %)
Total number of binary PPIs (saturation %)106 (9.01 %)
The number (and %) of affected PPIs47 (44.34 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI3.347
Assortativity coefficient-0.4643
The network average Clustering coefficient0.514
The number (and %) of a zero Clustering coefficients17 (34.69 %)
The number (and %) of a zero Betweenness Centrality35 (71.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TPK1,CYCS All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); BCL2L1 (see 1 fusions); ACP6 (see 1 fusions); TRAF6 (see 1 fusions); SPATA20 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TPK1oncoprotein000TPK_B1_binding (PF04265, IPR007373, SM00983): Thiamin pyrophosphokinase, vitamin B1 binding domain
TPK_catalytic (PF04263, IPR007371): Thiamin pyrophosphokinase, catalytic domain
2 CYCSparental protein470.0322034.000Cytochrom_C (PF00034, IPR003088): Cytochrome c
3 ACAT1interactor40.6671.000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACP6protein found in more fusions31.0000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
5 AGTPBP1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
6 APAF1suppressor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NB-ARC (PF00931, IPR002182): NB-ARC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
7 ARL2interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 BAXsuppressor60.6003.333Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
9 BCL2L1oncoprotein60.7002.333Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
10 C19orf70interactor100QIL1 (PF15884, IPR026769): Protein QIL1
11 CASP9oncoprotein40.8330.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CATsuppressor31.0000Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
13 CCDC58interactor200Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
14 CDK2suppressor60.4005.333Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 COQ10Binteractor100Polyketide_cyc (PF03364, IPR005031): Polyketide cyclase / dehydrase and lipid transport
16 COQ6interactor31.0000FAD_binding_3 (PF01494, IPR002938): FAD binding domain
Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
17 COQ7interactor31.0000COQ7 (PF03232, IPR011566): Ubiquinone biosynthesis protein COQ7
18 COX4I2interactor100COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
19 CUL9interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Cullin (PF00888, IPR001373, SM00182): Cullin family
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SDA1 (PF05285, IPR007949): SDA1
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
20 CYB5Asuppressor100Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
21 CYB5Binteractor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
22 CYC1interactor30.6671.000Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
23 ETFRF1interactor200Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
24 FMC1interactor100Complex1_LYR_2 (PF13233): Complex1_LYR-like
25 GLRX2interactor100Glutaredoxin (PF00462, IPR002109): Glutaredoxin
26 GPD1Linteractor100NAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
27 GSTK1interactor31.0000DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
28 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
29 HSPA8oncoprotein40.6671.667HSP70 (PF00012, IPR013126): Hsp70 protein
30 HSPB1oncoprotein41.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
31 IMPA1interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
32 IMPA2interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
33 ITGA4interactor70.4008.667FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
34 KRT40interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
35 MED20interactor40.6672.000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
36 MED23interactor31.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
37 MED4interactor31.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
38 NDOR1interactor200FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
39 NLE1oncoprotein100NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40 NME4interactor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
41 PRDX2interactor60.3339.333AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
42 PTPMT1interactor50.5003.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
43 SPATA20protein found in more fusions31.0000Thioredox_DsbH (PF03190, IPR004879): Protein of unknown function, DUF255
GlcNAc_2-epim (PF07221, IPR010819): N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
44 SUGCTinteractor200CoA_transf_3 (PF02515, IPR003673): CoA-transferase family III
45 TRAF6protein found in more fusions31.0000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46 TRUB2interactor31.0000TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
47 UQCRC1interactor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
48 UQCRFS1interactor50.4006.000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
49 VDAC1interactor70.33313.667Porin_3 (PF01459, IPR027246): Eukaryotic porin

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