Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TPK1, CYCS (from a repository: Mon Mar 25 20:04:58 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins9 (18.37 %)
The number (and %) of the tumor suppressors5 (10.20 %)
Total number of binary PPIs (saturation %)106 (9.01 %)
The number (and %) of affected PPIs47 (44.34 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI3.347
Assortativity coefficient-0.4643
The network average Clustering coefficient0.514
The number (and %) of a zero Clustering coefficients17 (34.69 %)
The number (and %) of a zero Betweenness Centrality35 (71.43 %)


List of the fusions

PPI for parental proteins: TPK1,CYCS All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); BCL2L1 (see 1 fusions); ACP6 (see 1 fusions); TRAF6 (see 1 fusions); SPATA20 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TPK1oncoprotein000TPK_B1_binding (PF04265, IPR007373, SM00983): Thiamin pyrophosphokinase, vitamin B1 binding domain
TPK_catalytic (PF04263, IPR007371): Thiamin pyrophosphokinase, catalytic domain
2 CYCSparental protein470.0322034.000Cytochrom_C (PF00034, IPR003088): Cytochrome c
3 ACAT1interactor40.6671.000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACP6protein found in more fusions31.0000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
5 AGTPBP1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
6 APAF1suppressor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NB-ARC (PF00931, IPR002182): NB-ARC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
7 ARL2interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 BAXsuppressor60.6003.333Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
9 BCL2L1oncoprotein60.7002.333Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
10 C19orf70interactor100QIL1 (PF15884, IPR026769): Protein QIL1
11 CASP9oncoprotein40.8330.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CATsuppressor31.0000Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
13 CCDC58interactor200Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
14 CDK2suppressor60.4005.333Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 COQ10Binteractor100Polyketide_cyc (PF03364, IPR005031): Polyketide cyclase / dehydrase and lipid transport
16 COQ6interactor31.0000FAD_binding_3 (PF01494, IPR002938): FAD binding domain
Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
17 COQ7interactor31.0000COQ7 (PF03232, IPR011566): Ubiquinone biosynthesis protein COQ7
18 COX4I2interactor100COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
19 CUL9interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Cullin (PF00888, IPR001373, SM00182): Cullin family
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SDA1 (PF05285, IPR007949): SDA1
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
20 CYB5Asuppressor100Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
21 CYB5Binteractor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
22 CYC1interactor30.6671.000Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
23 ETFRF1interactor200Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
24 FMC1interactor100Complex1_LYR_2 (PF13233): Complex1_LYR-like
25 GLRX2interactor100Glutaredoxin (PF00462, IPR002109): Glutaredoxin
26 GPD1Linteractor100NAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
27 GSTK1interactor31.0000DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
28 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
29 HSPA8oncoprotein40.6671.667HSP70 (PF00012, IPR013126): Hsp70 protein
30 HSPB1oncoprotein41.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
31 IMPA1interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
32 IMPA2interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
33 ITGA4interactor70.4008.667FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
34 KRT40interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
35 MED20interactor40.6672.000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
36 MED23interactor31.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
37 MED4interactor31.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
38 NDOR1interactor200FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
39 NLE1oncoprotein100NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40 NME4interactor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
41 PRDX2interactor60.3339.333AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
42 PTPMT1interactor50.5003.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
43 SPATA20protein found in more fusions31.0000Thioredox_DsbH (PF03190, IPR004879): Protein of unknown function, DUF255
GlcNAc_2-epim (PF07221, IPR010819): N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
44 SUGCTinteractor200CoA_transf_3 (PF02515, IPR003673): CoA-transferase family III
45 TRAF6protein found in more fusions31.0000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46 TRUB2interactor31.0000TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
47 UQCRC1interactor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
48 UQCRFS1interactor50.4006.000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
49 VDAC1interactor70.33313.667Porin_3 (PF01459, IPR027246): Eukaryotic porin

B a c k    t o    T o p ⇑