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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SEC22A, LOC349160 (from a repository: Thu Sep 5 02:40:28 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins4 (23.53 %)
The number (and %) of the tumor suppressors2 (11.76 %)
Total number of binary PPIs (saturation %)28 (20.59 %)
The number (and %) of affected PPIs15 (53.57 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.353
Assortativity coefficient-0.4077
The network average Clustering coefficient0.356
The number (and %) of a zero Clustering coefficients9 (52.94 %)
The number (and %) of a zero Betweenness Centrality13 (76.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LOC349160,SEC22A All fusions
Proteins found in more fusions DSP (see 4 fusions); SFTPC (see 1 fusions); PCNA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LOC349160interactor000NA
2 SEC22Aparental protein150.048197.000Longin (PF13774, IPR010908): Regulated-SNARE-like domain
3 DSPsuppressor200APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
4 DTX2oncoprotein200WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
5 EDAinteractor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
6 ERLIN1interactor100Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
7 FATE1interactor21.0000Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
8 MSR1interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Macscav_rec (PF03523, IPR003543): Macrophage scavenger receptor
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
9 PCNAoncoprotein200PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
10 RNF5interactor200zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
11 SFTPCprotein found in more fusions40.6671.000BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
12 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
13 STX4oncoprotein31.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
14 STX5interactor30.6671.000Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
15 SYNE4interactor30.6671.000KASH (PF10541, IPR012315): Nuclear envelope localisation domain
16 TMEM79interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
17 USO1interactor31.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding

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