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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GGT7, C1orf105 (from a repository: Thu Jul 25 08:23:25 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins1 (9.09 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)15 (27.27 %)
The number (and %) of affected PPIs10 (66.67 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.5004
The network average Clustering coefficient0.400
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality9 (81.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GGT7,C1orf105 All fusions
Proteins found in more fusions APP (see 5 fusions); GGT7 (see 2 fusions); LIMD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GGT7parental protein70.06728.000G_glu_transpept (PF01019, IPR000101): Gamma-glutamyltranspeptidase
2 C1orf105parental protein30.3334.000DUF4548 (PF15081, IPR027845): Domain of unknown function (DUF4548)
3 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
5 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
6 GPR25interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 LHFPL5interactor100L_HMGIC_fpl (PF10242, IPR019372): Lipoma HMGIC fusion partner-like protein
8 LIMD1suppressor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
9 MALLinteractor100MARVEL (PF01284, IPR008253): Membrane-associating domain
PsbM (PF05151, IPR007826): Photosystem II reaction centre M protein (PsbM)
10 PSMA3interactor200Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
11 TMEM242interactor100DUF1358 (PF07096, IPR009792): Protein of unknown function (DUF1358)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence

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