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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MT1G, RPS6KC1 (from a repository: Sat Feb 23 13:27:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins2 (22.22 %)
The number (and %) of the tumor suppressors1 (11.11 %)
Total number of binary PPIs (saturation %)10 (27.78 %)
The number (and %) of affected PPIs7 (70.00 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.556
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients9 (100.00 %)
The number (and %) of a zero Betweenness Centrality7 (77.78 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RPS6KC1,MT1G All fusions
Proteins found in more fusions HSP90AA1 (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RPS6KC1parental protein5020.000MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PX (PF00787, IPR001683, SM00312): PX domain
2 MT1Gparental protein202.000Metallothio (PF00131, IPR003019): Metallothionein
3 DENND6Ainteractor100SPA (PF08616): Stabilization of polarity axis
Avl9 (PF09794, IPR018307): Transport protein Avl9
4 HSP90AA1oncoprotein200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
5 IQGAP1interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
6 PRDX3interactor200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
7 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
8 SPHK1interactor100DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
9 SPINK7suppressor100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain

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